6BFS

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001821	biological_process	histamine secretion
C	0001892	biological_process	embryonic placenta development
C	0005125	molecular_function	cytokine activity
C	0005129	molecular_function	granulocyte macrophage colony-stimulating factor receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008083	molecular_function	growth factor activity
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009966	biological_process	regulation of signal transduction
C	0010468	biological_process	regulation of gene expression
C	0010628	biological_process	positive regulation of gene expression
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0030099	biological_process	myeloid cell differentiation
C	0030223	biological_process	neutrophil differentiation
C	0030224	biological_process	monocyte differentiation
C	0030225	biological_process	macrophage differentiation
C	0030335	biological_process	positive regulation of cell migration
C	0030526	cellular_component	granulocyte macrophage colony-stimulating factor receptor complex
C	0032747	biological_process	positive regulation of interleukin-23 production
C	0034021	biological_process	response to silicon dioxide
C	0034405	biological_process	response to fluid shear stress
C	0038157	biological_process	granulocyte-macrophage colony-stimulating factor signaling pathway
C	0042045	biological_process	epithelial fluid transport
C	0042127	biological_process	regulation of cell population proliferation
C	0043011	biological_process	myeloid dendritic cell differentiation
C	0045187	biological_process	regulation of circadian sleep/wake cycle, sleep
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0050793	biological_process	regulation of developmental process
C	0070665	biological_process	positive regulation of leukocyte proliferation
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071803	biological_process	positive regulation of podosome assembly
C	0097011	biological_process	cellular response to granulocyte macrophage colony-stimulating factor stimulus
C	0097028	biological_process	dendritic cell differentiation
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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site_id	PS00702
Number of Residues	9
Details	GM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC

Chain	Residue	Details
C	CYS88-CYS96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

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