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6BFS

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies

Functional Information from GO Data
ChainGOidnamespacecontents
C0001821biological_processhistamine secretion
C0001892biological_processembryonic placenta development
C0005125molecular_functioncytokine activity
C0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0008083molecular_functiongrowth factor activity
C0008283biological_processcell population proliferation
C0008284biological_processpositive regulation of cell population proliferation
C0010468biological_processregulation of gene expression
C0010628biological_processpositive regulation of gene expression
C0010744biological_processpositive regulation of macrophage derived foam cell differentiation
C0030099biological_processmyeloid cell differentiation
C0030223biological_processneutrophil differentiation
C0030224biological_processmonocyte differentiation
C0030225biological_processmacrophage differentiation
C0030335biological_processpositive regulation of cell migration
C0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
C0032747biological_processpositive regulation of interleukin-23 production
C0034021biological_processresponse to silicon dioxide
C0034405biological_processresponse to fluid shear stress
C0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
C0042045biological_processepithelial fluid transport
C0042127biological_processregulation of cell population proliferation
C0043011biological_processmyeloid dendritic cell differentiation
C0043231cellular_componentintracellular membrane-bounded organelle
C0045187biological_processregulation of circadian sleep/wake cycle, sleep
C0045892biological_processnegative regulation of DNA-templated transcription
C0070665biological_processpositive regulation of leukocyte proliferation
C0071222biological_processcellular response to lipopolysaccharide
C0071803biological_processpositive regulation of podosome assembly
C0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
C0097028biological_processdendritic cell differentiation
C0097696biological_processcell surface receptor signaling pathway via STAT
C2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
LTYR192-HIS198

site_idPS00702
Number of Residues9
DetailsGM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC
ChainResidueDetails
CCYS88-CYS96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1737041
ChainResidueDetails
CSER5
CSER7
CSER9

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:1737041
ChainResidueDetails
CTHR10

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
CASN27
CASN37

226707

PDB entries from 2024-10-30

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