6BE6
ADAM10 Extracellular Domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TFAHEVGHNF |
| Chain | Residue | Details |
| A | THR380-PHE389 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:29430990 |
| Chain | Residue | Details |
| A | GLU384 | |
| B | GLU384 | |
| C | GLU384 | |
| D | GLU384 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24055016, ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:37516108, ECO:0007744|PDB:6BDZ, ECO:0007744|PDB:6BE6, ECO:0007744|PDB:8ESV |
| Chain | Residue | Details |
| D | HIS383 | |
| D | HIS393 | |
| A | HIS383 | |
| A | HIS393 | |
| B | HIS383 | |
| B | HIS393 | |
| C | HIS383 | |
| C | HIS393 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:37516108, ECO:0007744|PDB:6BE6, ECO:0007744|PDB:8ESV |
| Chain | Residue | Details |
| D | HIS387 | |
| A | HIS387 | |
| B | HIS387 | |
| C | HIS387 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN267 | |
| A | GLN439 | |
| A | GLN551 | |
| B | GLN267 | |
| B | GLN439 | |
| B | GLN551 | |
| C | GLN267 | |
| C | GLN439 | |
| C | GLN551 | |
| D | GLN267 | |
| D | GLN439 | |
| D | GLN551 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:29224781, ECO:0007744|PDB:6BDZ, ECO:0007744|PDB:6BE6 |
| Chain | Residue | Details |
| A | ASN278 | |
| B | ASN278 | |
| C | ASN278 | |
| D | ASN278 |
