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6BCX

mTORC1 structure refined to 3.0 angstroms

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000822molecular_functioninositol hexakisphosphate binding
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0002181biological_processcytoplasmic translation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006446biological_processregulation of translational initiation
A0006511biological_processubiquitin-dependent protein catabolic process
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009615biological_processresponse to virus
A0009791biological_processpost-embryonic development
A0009891biological_processpositive regulation of biosynthetic process
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010508biological_processpositive regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0019216biological_processregulation of lipid metabolic process
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0038203biological_processTORC2 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045597biological_processpositive regulation of cell differentiation
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045824biological_processnegative regulation of innate immune response
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045947biological_processnegative regulation of translational initiation
A0045948biological_processpositive regulation of translational initiation
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050821biological_processprotein stabilization
A0050882biological_processvoluntary musculoskeletal movement
A0051219molecular_functionphosphoprotein binding
A0051240biological_processpositive regulation of multicellular organismal process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0097700biological_processvascular endothelial cell response to laminar fluid shear stress
A0106310molecular_functionprotein serine kinase activity
A0140367biological_processantibacterial innate immune response
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1902554cellular_componentserine/threonine protein kinase complex
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1903940biological_processnegative regulation of TORC2 signaling
A1904059biological_processregulation of locomotor rhythm
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905671biological_processregulation of lysosome organization
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
A2000767biological_processpositive regulation of cytoplasmic translation
A2000785biological_processregulation of autophagosome assembly
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000822molecular_functioninositol hexakisphosphate binding
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0002181biological_processcytoplasmic translation
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006446biological_processregulation of translational initiation
B0006511biological_processubiquitin-dependent protein catabolic process
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007040biological_processlysosome organization
B0007281biological_processgerm cell development
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009615biological_processresponse to virus
B0009791biological_processpost-embryonic development
B0009891biological_processpositive regulation of biosynthetic process
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010508biological_processpositive regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016605cellular_componentPML body
B0016740molecular_functiontransferase activity
B0019216biological_processregulation of lipid metabolic process
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035264biological_processmulticellular organism growth
B0038202biological_processTORC1 signaling
B0038203biological_processTORC2 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045335cellular_componentphagocytic vesicle
B0045597biological_processpositive regulation of cell differentiation
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045824biological_processnegative regulation of innate immune response
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045947biological_processnegative regulation of translational initiation
B0045948biological_processpositive regulation of translational initiation
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050821biological_processprotein stabilization
B0050882biological_processvoluntary musculoskeletal movement
B0051219molecular_functionphosphoprotein binding
B0051240biological_processpositive regulation of multicellular organismal process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0097700biological_processvascular endothelial cell response to laminar fluid shear stress
B0106310molecular_functionprotein serine kinase activity
B0140367biological_processantibacterial innate immune response
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1902554cellular_componentserine/threonine protein kinase complex
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1903940biological_processnegative regulation of TORC2 signaling
B1904059biological_processregulation of locomotor rhythm
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905671biological_processregulation of lysosome organization
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990253biological_processcellular response to leucine starvation
B2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
B2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
B2000767biological_processpositive regulation of cytoplasmic translation
B2000785biological_processregulation of autophagosome assembly
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006974biological_processDNA damage response
D0007010biological_processcytoskeleton organization
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0030307biological_processpositive regulation of cell growth
D0030674molecular_functionprotein-macromolecule adaptor activity
D0030838biological_processpositive regulation of actin filament polymerization
D0031669biological_processcellular response to nutrient levels
D0031929biological_processTOR signaling
D0031931cellular_componentTORC1 complex
D0031932cellular_componentTORC2 complex
D0032008biological_processpositive regulation of TOR signaling
D0032956biological_processregulation of actin cytoskeleton organization
D0038202biological_processTORC1 signaling
D0038203biological_processTORC2 signaling
D0043066biological_processnegative regulation of apoptotic process
D0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045821biological_processpositive regulation of glycolytic process
D0046889biological_processpositive regulation of lipid biosynthetic process
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0071456biological_processcellular response to hypoxia
D0071470biological_processcellular response to osmotic stress
D1902554cellular_componentserine/threonine protein kinase complex
D1905857biological_processpositive regulation of pentose-phosphate shunt
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006974biological_processDNA damage response
E0007010biological_processcytoskeleton organization
E0010507biological_processnegative regulation of autophagy
E0016020cellular_componentmembrane
E0030307biological_processpositive regulation of cell growth
E0030674molecular_functionprotein-macromolecule adaptor activity
E0030838biological_processpositive regulation of actin filament polymerization
E0031669biological_processcellular response to nutrient levels
E0031929biological_processTOR signaling
E0031931cellular_componentTORC1 complex
E0031932cellular_componentTORC2 complex
E0032008biological_processpositive regulation of TOR signaling
E0032956biological_processregulation of actin cytoskeleton organization
E0038202biological_processTORC1 signaling
E0038203biological_processTORC2 signaling
E0043066biological_processnegative regulation of apoptotic process
E0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0045821biological_processpositive regulation of glycolytic process
E0046889biological_processpositive regulation of lipid biosynthetic process
E0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0071456biological_processcellular response to hypoxia
E0071470biological_processcellular response to osmotic stress
E1902554cellular_componentserine/threonine protein kinase complex
E1905857biological_processpositive regulation of pentose-phosphate shunt
W0000045biological_processautophagosome assembly
W0001558biological_processregulation of cell growth
W0001938biological_processpositive regulation of endothelial cell proliferation
W0002181biological_processcytoplasmic translation
W0005515molecular_functionprotein binding
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005764cellular_componentlysosome
W0005765cellular_componentlysosomal membrane
W0005829cellular_componentcytosol
W0006974biological_processDNA damage response
W0008361biological_processregulation of cell size
W0009267biological_processcellular response to starvation
W0009410biological_processresponse to xenobiotic stimulus
W0010494cellular_componentcytoplasmic stress granule
W0010506biological_processregulation of autophagy
W0010507biological_processnegative regulation of autophagy
W0010646biological_processregulation of cell communication
W0016020cellular_componentmembrane
W0019901molecular_functionprotein kinase binding
W0023051biological_processregulation of signaling
W0030291molecular_functionprotein serine/threonine kinase inhibitor activity
W0030295molecular_functionprotein kinase activator activity
W0030307biological_processpositive regulation of cell growth
W0030425cellular_componentdendrite
W0030674molecular_functionprotein-macromolecule adaptor activity
W0031267molecular_functionsmall GTPase binding
W0031669biological_processcellular response to nutrient levels
W0031929biological_processTOR signaling
W0031931cellular_componentTORC1 complex
W0032008biological_processpositive regulation of TOR signaling
W0035176biological_processsocial behavior
W0038202biological_processTORC1 signaling
W0043025cellular_componentneuronal cell body
W0044877molecular_functionprotein-containing complex binding
W0045672biological_processpositive regulation of osteoclast differentiation
W0045821biological_processpositive regulation of glycolytic process
W0045945biological_processpositive regulation of transcription by RNA polymerase III
W0045947biological_processnegative regulation of translational initiation
W0045948biological_processpositive regulation of translational initiation
W0046889biological_processpositive regulation of lipid biosynthetic process
W0061462biological_processprotein localization to lysosome
W0065008biological_processregulation of biological quality
W0071230biological_processcellular response to amino acid stimulus
W0071233biological_processcellular response to L-leucine
W0071333biological_processcellular response to glucose stimulus
W0071456biological_processcellular response to hypoxia
W0071470biological_processcellular response to osmotic stress
W0071889molecular_function14-3-3 protein binding
W0140767molecular_functionenzyme-substrate adaptor activity
W1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
W1901331biological_processpositive regulation of odontoblast differentiation
W1902554cellular_componentserine/threonine protein kinase complex
W1904263biological_processpositive regulation of TORC1 signaling
W1905857biological_processpositive regulation of pentose-phosphate shunt
X0000082biological_processG1/S transition of mitotic cell cycle
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0006417biological_processregulation of translation
X0008190molecular_functioneukaryotic initiation factor 4E binding
X0017148biological_processnegative regulation of translation
X0030371molecular_functiontranslation repressor activity
X0031369molecular_functiontranslation initiation factor binding
X0031929biological_processTOR signaling
X0045931biological_processpositive regulation of mitotic cell cycle
X0045947biological_processnegative regulation of translational initiation
Y0000045biological_processautophagosome assembly
Y0001558biological_processregulation of cell growth
Y0001938biological_processpositive regulation of endothelial cell proliferation
Y0002181biological_processcytoplasmic translation
Y0005515molecular_functionprotein binding
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005764cellular_componentlysosome
Y0005765cellular_componentlysosomal membrane
Y0005829cellular_componentcytosol
Y0006974biological_processDNA damage response
Y0008361biological_processregulation of cell size
Y0009267biological_processcellular response to starvation
Y0009410biological_processresponse to xenobiotic stimulus
Y0010494cellular_componentcytoplasmic stress granule
Y0010506biological_processregulation of autophagy
Y0010507biological_processnegative regulation of autophagy
Y0010646biological_processregulation of cell communication
Y0016020cellular_componentmembrane
Y0019901molecular_functionprotein kinase binding
Y0023051biological_processregulation of signaling
Y0030291molecular_functionprotein serine/threonine kinase inhibitor activity
Y0030295molecular_functionprotein kinase activator activity
Y0030307biological_processpositive regulation of cell growth
Y0030425cellular_componentdendrite
Y0030674molecular_functionprotein-macromolecule adaptor activity
Y0031267molecular_functionsmall GTPase binding
Y0031669biological_processcellular response to nutrient levels
Y0031929biological_processTOR signaling
Y0031931cellular_componentTORC1 complex
Y0032008biological_processpositive regulation of TOR signaling
Y0035176biological_processsocial behavior
Y0038202biological_processTORC1 signaling
Y0043025cellular_componentneuronal cell body
Y0044877molecular_functionprotein-containing complex binding
Y0045672biological_processpositive regulation of osteoclast differentiation
Y0045821biological_processpositive regulation of glycolytic process
Y0045945biological_processpositive regulation of transcription by RNA polymerase III
Y0045947biological_processnegative regulation of translational initiation
Y0045948biological_processpositive regulation of translational initiation
Y0046889biological_processpositive regulation of lipid biosynthetic process
Y0061462biological_processprotein localization to lysosome
Y0065008biological_processregulation of biological quality
Y0071230biological_processcellular response to amino acid stimulus
Y0071233biological_processcellular response to L-leucine
Y0071333biological_processcellular response to glucose stimulus
Y0071456biological_processcellular response to hypoxia
Y0071470biological_processcellular response to osmotic stress
Y0071889molecular_function14-3-3 protein binding
Y0140767molecular_functionenzyme-substrate adaptor activity
Y1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Y1901331biological_processpositive regulation of odontoblast differentiation
Y1902554cellular_componentserine/threonine protein kinase complex
Y1904263biological_processpositive regulation of TORC1 signaling
Y1905857biological_processpositive regulation of pentose-phosphate shunt
Z0000082biological_processG1/S transition of mitotic cell cycle
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005829cellular_componentcytosol
Z0006417biological_processregulation of translation
Z0008190molecular_functioneukaryotic initiation factor 4E binding
Z0017148biological_processnegative regulation of translation
Z0030371molecular_functiontranslation repressor activity
Z0031369molecular_functiontranslation initiation factor binding
Z0031929biological_processTOR signaling
Z0045931biological_processpositive regulation of mitotic cell cycle
Z0045947biological_processnegative regulation of translational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue ATP A 3000
ChainResidue
ASER2165
AMET2345
AILE2356
AMG3001
AMG3002
AGLN2167
APRO2169
ALYS2187
AGLU2190
AGLY2238
ATRP2239
AVAL2240
ATHR2245

site_idAC2
Number of Residues2
Detailsbinding site for residue MG A 3001
ChainResidue
AASN2343
AATP3000

site_idAC3
Number of Residues2
Detailsbinding site for residue MG A 3002
ChainResidue
AGLU2190
AATP3000

site_idAC4
Number of Residues13
Detailsbinding site for residue ATP B 3000
ChainResidue
BSER2165
BGLN2167
BPRO2169
BLYS2187
BGLU2190
BGLY2238
BTRP2239
BVAL2240
BTHR2245
BMET2345
BILE2356
BMG3001
BMG3002

site_idAC5
Number of Residues2
Detailsbinding site for residue MG B 3001
ChainResidue
BASN2343
BATP3000

site_idAC6
Number of Residues2
Detailsbinding site for residue MG B 3002
ChainResidue
BGLU2190
BATP3000

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
DMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues68
DetailsRepeat: {"description":"HEAT 12"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues78
DetailsRepeat: {"description":"HEAT 15"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues78
DetailsRepeat: {"description":"HEAT 18"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues84
DetailsRepeat: {"description":"HEAT 19"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues78
DetailsRepeat: {"description":"HEAT 20"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues72
DetailsRepeat: {"description":"HEAT 21"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues96
DetailsRepeat: {"description":"HEAT 22"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues78
DetailsRepeat: {"description":"HEAT 25"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues72
DetailsRepeat: {"description":"HEAT 26"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues76
DetailsRepeat: {"description":"HEAT 27"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues86
DetailsRepeat: {"description":"HEAT 28"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues72
DetailsRepeat: {"description":"HEAT 29"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues94
DetailsRepeat: {"description":"HEAT 30"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues74
DetailsRepeat: {"description":"HEAT 31"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues66
DetailsRepeat: {"description":"HEAT 32"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues72
DetailsRepeat: {"description":"TPR 1"}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues50
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues66
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues60
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues66
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues66
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues64
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues86
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues74
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues108
DetailsRepeat: {"description":"TPR 12"}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues118
DetailsRepeat: {"description":"TPR 13"}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues64
DetailsRepeat: {"description":"TPR 14"}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues78
DetailsRepeat: {"description":"TPR 15"}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues68
DetailsRepeat: {"description":"TPR 16"}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues110
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues264
DetailsRegion: {"description":"Sufficient for interaction with the FKBP1A/rapamycin complex","evidences":[{"source":"UniProtKB","id":"Q9JLN9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues76
DetailsRegion: {"description":"Interaction with MLST8"}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues80
DetailsCompositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33158864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ZWM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19487463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by TBK1","evidences":[{"source":"PubMed","id":"21576368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29150432","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21576368","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"24247430","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37979583","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues80
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues78
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues78
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues78
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues78
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues82
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23636326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"34741373","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)","evidences":[{"source":"PubMed","id":"38395307","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28489822","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues82
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues82
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues78
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues80
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues80
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"31530866","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30197302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32561715","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI63
Number of Residues8
DetailsMotif: {"description":"TOS motif","evidences":[{"source":"PubMed","id":"12747827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24403073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI64
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12588975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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