Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BCR

Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0008104	biological_process	protein localization
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0021762	biological_process	substantia nigra development
A	0032991	cellular_component	protein-containing complex
A	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0044325	molecular_function	transmembrane transporter binding
A	0045202	cellular_component	synapse
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0070062	cellular_component	extracellular exosome
A	0071889	molecular_function	14-3-3 protein binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006605	biological_process	protein targeting
B	0007165	biological_process	signal transduction
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0008104	biological_process	protein localization
B	0016020	cellular_component	membrane
B	0019904	molecular_function	protein domain specific binding
B	0021762	biological_process	substantia nigra development
B	0032991	cellular_component	protein-containing complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0044325	molecular_function	transmembrane transporter binding
B	0045202	cellular_component	synapse
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0070062	cellular_component	extracellular exosome
B	0071889	molecular_function	14-3-3 protein binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006605	biological_process	protein targeting
E	0007165	biological_process	signal transduction
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0008104	biological_process	protein localization
E	0016020	cellular_component	membrane
E	0019904	molecular_function	protein domain specific binding
E	0021762	biological_process	substantia nigra development
E	0032991	cellular_component	protein-containing complex
E	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0044325	molecular_function	transmembrane transporter binding
E	0045202	cellular_component	synapse
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0070062	cellular_component	extracellular exosome
E	0071889	molecular_function	14-3-3 protein binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005925	cellular_component	focal adhesion
F	0006605	biological_process	protein targeting
F	0007165	biological_process	signal transduction
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0008104	biological_process	protein localization
F	0016020	cellular_component	membrane
F	0019904	molecular_function	protein domain specific binding
F	0021762	biological_process	substantia nigra development
F	0032991	cellular_component	protein-containing complex
F	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0044325	molecular_function	transmembrane transporter binding
F	0045202	cellular_component	synapse
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0070062	cellular_component	extracellular exosome
F	0071889	molecular_function	14-3-3 protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 300

Chain	Residue
A	ASP81
A	GLU84
A	HOH433
B	HOH423

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 301

Chain	Residue
A	GLU84
A	GLU87
A	ARG91

site_id	AC3
Number of Residues	8
Details	binding site for residue PEG A 302

Chain	Residue
A	ASP21
A	THR24
A	CYS25
B	LYS85
F	GLU99
F	HOH480
A	MET1
A	LYS9

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 303

Chain	Residue
A	ASP20
A	THR24
A	HOH457

site_id	AC5
Number of Residues	7
Details	binding site for residue MG B 301

Chain	Residue
B	GLU84
B	GLU87
B	ARG91
B	HOH420
B	HOH456
B	HOH471
F	HOH486

site_id	AC6
Number of Residues	8
Details	binding site for residue 1PE B 302

Chain	Residue
A	ASP81
A	TYR82
B	MET1
B	LEU6
B	LYS9
B	ASP21
B	THR24
B	CYS25

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO B 303

Chain	Residue
B	ASP20
B	ILE93

site_id	AC8
Number of Residues	6
Details	binding site for residue MG E 300

Chain	Residue
E	ASP81
E	GLU84
E	HOH401
E	HOH430
E	HOH497
F	HOH472

site_id	AC9
Number of Residues	6
Details	binding site for residue ETF E 301

Chain	Residue
B	THR215
B	MET218
B	GLN219
B	ARG222
E	PHE196
E	ILE200

site_id	AD1
Number of Residues	2
Details	binding site for residue PEG E 302

Chain	Residue
E	ASP20
E	HOH502

site_id	AD2
Number of Residues	5
Details	binding site for residue PEG E 303

Chain	Residue
E	ARG56
E	TRP59
E	ARG60
E	GLU131
E	HOH410

site_id	AD3
Number of Residues	3
Details	binding site for residue MG F 300

Chain	Residue
F	GLU84
F	GLU87
F	HOH403

site_id	AD4
Number of Residues	6
Details	binding site for residue ETF F 301

Chain	Residue
A	PHE196
A	ILE200
A	ARG222
F	THR215
F	MET218
F	GLN219

site_id	AD5
Number of Residues	5
Details	binding site for residue PEG F 302

Chain	Residue
F	ASP20
F	THR24
F	ARG55
F	HOH445
F	HOH467

site_id	AD6
Number of Residues	8
Details	binding site for residue 1PE F 303

Chain	Residue
E	ASP81
E	TYR82
E	LYS85
F	MET1
F	LEU6
F	LYS9
F	ASP21
F	THR24

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO F 304

Chain	Residue
E	ARG18
F	GLY54
F	ARG55
F	ALA58
F	HOH425

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR211-SER230

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER336
D	SER336
G	SER336
H	SER336
E	ARG56
E	ARG127
F	ARG56
F	ARG127

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	TPO340
D	TPO340
G	TPO340
H	TPO340

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
C	SER346
F	LYS3
F	LYS68
F	LYS115
D	SER346
G	SER346
H	SER346
B	LYS68
B	LYS115
E	LYS3
E	LYS68
E	LYS115

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS49
B	LYS49
E	LYS49
F	LYS49

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:Q9CQV8

Chain	Residue	Details
A	TYR82
A	TYR104
B	TYR82
B	TYR104
E	TYR82
E	TYR104
F	TYR82
F	TYR104

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68254

Chain	Residue	Details
A	SER92
B	SER92
E	SER92
F	SER92

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:9360956, ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	SER232
B	SER232
E	SER232
F	SER232

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS49
B	LYS49
E	LYS49
F	LYS49

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)