6BCR
Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005925 | cellular_component | focal adhesion |
A | 0006605 | biological_process | protein targeting |
A | 0007165 | biological_process | signal transduction |
A | 0007264 | biological_process | small GTPase-mediated signal transduction |
A | 0008104 | biological_process | protein localization |
A | 0016020 | cellular_component | membrane |
A | 0019904 | molecular_function | protein domain specific binding |
A | 0021762 | biological_process | substantia nigra development |
A | 0032991 | cellular_component | protein-containing complex |
A | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
A | 0042802 | molecular_function | identical protein binding |
A | 0044325 | molecular_function | transmembrane transporter binding |
A | 0045202 | cellular_component | synapse |
A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071889 | molecular_function | 14-3-3 protein binding |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005925 | cellular_component | focal adhesion |
B | 0006605 | biological_process | protein targeting |
B | 0007165 | biological_process | signal transduction |
B | 0007264 | biological_process | small GTPase-mediated signal transduction |
B | 0008104 | biological_process | protein localization |
B | 0016020 | cellular_component | membrane |
B | 0019904 | molecular_function | protein domain specific binding |
B | 0021762 | biological_process | substantia nigra development |
B | 0032991 | cellular_component | protein-containing complex |
B | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
B | 0042802 | molecular_function | identical protein binding |
B | 0044325 | molecular_function | transmembrane transporter binding |
B | 0045202 | cellular_component | synapse |
B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071889 | molecular_function | 14-3-3 protein binding |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0005925 | cellular_component | focal adhesion |
E | 0006605 | biological_process | protein targeting |
E | 0007165 | biological_process | signal transduction |
E | 0007264 | biological_process | small GTPase-mediated signal transduction |
E | 0008104 | biological_process | protein localization |
E | 0016020 | cellular_component | membrane |
E | 0019904 | molecular_function | protein domain specific binding |
E | 0021762 | biological_process | substantia nigra development |
E | 0032991 | cellular_component | protein-containing complex |
E | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
E | 0042802 | molecular_function | identical protein binding |
E | 0044325 | molecular_function | transmembrane transporter binding |
E | 0045202 | cellular_component | synapse |
E | 0045892 | biological_process | negative regulation of DNA-templated transcription |
E | 0070062 | cellular_component | extracellular exosome |
E | 0071889 | molecular_function | 14-3-3 protein binding |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0005925 | cellular_component | focal adhesion |
F | 0006605 | biological_process | protein targeting |
F | 0007165 | biological_process | signal transduction |
F | 0007264 | biological_process | small GTPase-mediated signal transduction |
F | 0008104 | biological_process | protein localization |
F | 0016020 | cellular_component | membrane |
F | 0019904 | molecular_function | protein domain specific binding |
F | 0021762 | biological_process | substantia nigra development |
F | 0032991 | cellular_component | protein-containing complex |
F | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
F | 0042802 | molecular_function | identical protein binding |
F | 0044325 | molecular_function | transmembrane transporter binding |
F | 0045202 | cellular_component | synapse |
F | 0045892 | biological_process | negative regulation of DNA-templated transcription |
F | 0070062 | cellular_component | extracellular exosome |
F | 0071889 | molecular_function | 14-3-3 protein binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue MG A 300 |
Chain | Residue |
A | ASP81 |
A | GLU84 |
A | HOH433 |
B | HOH423 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 301 |
Chain | Residue |
A | GLU84 |
A | GLU87 |
A | ARG91 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue PEG A 302 |
Chain | Residue |
A | ASP21 |
A | THR24 |
A | CYS25 |
B | LYS85 |
F | GLU99 |
F | HOH480 |
A | MET1 |
A | LYS9 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue PEG A 303 |
Chain | Residue |
A | ASP20 |
A | THR24 |
A | HOH457 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue MG B 301 |
Chain | Residue |
B | GLU84 |
B | GLU87 |
B | ARG91 |
B | HOH420 |
B | HOH456 |
B | HOH471 |
F | HOH486 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue 1PE B 302 |
Chain | Residue |
A | ASP81 |
A | TYR82 |
B | MET1 |
B | LEU6 |
B | LYS9 |
B | ASP21 |
B | THR24 |
B | CYS25 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue EDO B 303 |
Chain | Residue |
B | ASP20 |
B | ILE93 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue MG E 300 |
Chain | Residue |
E | ASP81 |
E | GLU84 |
E | HOH401 |
E | HOH430 |
E | HOH497 |
F | HOH472 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue ETF E 301 |
Chain | Residue |
B | THR215 |
B | MET218 |
B | GLN219 |
B | ARG222 |
E | PHE196 |
E | ILE200 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue PEG E 302 |
Chain | Residue |
E | ASP20 |
E | HOH502 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue PEG E 303 |
Chain | Residue |
E | ARG56 |
E | TRP59 |
E | ARG60 |
E | GLU131 |
E | HOH410 |
site_id | AD3 |
Number of Residues | 3 |
Details | binding site for residue MG F 300 |
Chain | Residue |
F | GLU84 |
F | GLU87 |
F | HOH403 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue ETF F 301 |
Chain | Residue |
A | PHE196 |
A | ILE200 |
A | ARG222 |
F | THR215 |
F | MET218 |
F | GLN219 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue PEG F 302 |
Chain | Residue |
F | ASP20 |
F | THR24 |
F | ARG55 |
F | HOH445 |
F | HOH467 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue 1PE F 303 |
Chain | Residue |
E | ASP81 |
E | TYR82 |
E | LYS85 |
F | MET1 |
F | LEU6 |
F | LYS9 |
F | ASP21 |
F | THR24 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue EDO F 304 |
Chain | Residue |
E | ARG18 |
F | GLY54 |
F | ARG55 |
F | ALA58 |
F | HOH425 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | SER336 | |
D | SER336 | |
G | SER336 | |
H | SER336 | |
E | ARG56 | |
E | ARG127 | |
F | ARG56 | |
F | ARG127 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | TPO340 | |
D | TPO340 | |
G | TPO340 | |
H | TPO340 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
C | SER346 | |
F | LYS3 | |
F | LYS68 | |
F | LYS115 | |
D | SER346 | |
G | SER346 | |
H | SER346 | |
B | LYS68 | |
B | LYS115 | |
E | LYS3 | |
E | LYS68 | |
E | LYS115 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS49 | |
B | LYS49 | |
E | LYS49 | |
F | LYS49 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q9CQV8 |
Chain | Residue | Details |
A | TYR82 | |
A | TYR104 | |
B | TYR82 | |
B | TYR104 | |
E | TYR82 | |
E | TYR104 | |
F | TYR82 | |
F | TYR104 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68254 |
Chain | Residue | Details |
A | SER92 | |
B | SER92 | |
E | SER92 | |
F | SER92 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:9360956, ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER232 | |
B | SER232 | |
E | SER232 | |
F | SER232 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS49 | |
B | LYS49 | |
E | LYS49 | |
F | LYS49 |