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6BCA

A Complex between PH Domain of LbcRhoGEF (AKAP-Lbc) and Activated RhoA Bound to a GTP Analog

Functional Information from GO Data
ChainGOidnamespacecontents
C0000902biological_processcell morphogenesis
C0001764biological_processneuron migration
C0001822biological_processkidney development
C0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
C0002363biological_processalpha-beta T cell lineage commitment
C0003100biological_processregulation of systemic arterial blood pressure by endothelin
C0003189biological_processaortic valve formation
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006357biological_processregulation of transcription by RNA polymerase II
C0007010biological_processcytoskeleton organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007264biological_processsmall GTPase-mediated signal transduction
C0007266biological_processRho protein signal transduction
C0007519biological_processskeletal muscle tissue development
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010812biological_processnegative regulation of cell-substrate adhesion
C0010975biological_processregulation of neuron projection development
C0016477biological_processcell migration
C0016787molecular_functionhydrolase activity
C0017022molecular_functionmyosin binding
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0021795biological_processcerebral cortex cell migration
C0021861biological_processforebrain radial glial cell differentiation
C0030027cellular_componentlamellipodium
C0030036biological_processactin cytoskeleton organization
C0030054cellular_componentcell junction
C0030154biological_processcell differentiation
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030521biological_processandrogen receptor signaling pathway
C0030667cellular_componentsecretory granule membrane
C0031122biological_processcytoplasmic microtubule organization
C0031982cellular_componentvesicle
C0032154cellular_componentcleavage furrow
C0032467biological_processpositive regulation of cytokinesis
C0032587cellular_componentruffle membrane
C0032956biological_processregulation of actin cytoskeleton organization
C0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
C0033688biological_processregulation of osteoblast proliferation
C0034329biological_processcell junction assembly
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035385biological_processRoundabout signaling pathway
C0036089biological_processcleavage furrow formation
C0038027biological_processapolipoprotein A-I-mediated signaling pathway
C0042476biological_processodontogenesis
C0042995cellular_componentcell projection
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043149biological_processstress fiber assembly
C0043197cellular_componentdendritic spine
C0043296cellular_componentapical junction complex
C0043297biological_processapical junction assembly
C0043366biological_processbeta selection
C0043542biological_processendothelial cell migration
C0043931biological_processossification involved in bone maturation
C0044319biological_processwound healing, spreading of cells
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045666biological_processpositive regulation of neuron differentiation
C0045792biological_processnegative regulation of cell size
C0046638biological_processpositive regulation of alpha-beta T cell differentiation
C0050919biological_processnegative chemotaxis
C0051301biological_processcell division
C0051496biological_processpositive regulation of stress fiber assembly
C0051893biological_processregulation of focal adhesion assembly
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060193biological_processpositive regulation of lipase activity
C0061430biological_processbone trabecula morphogenesis
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0071222biological_processcellular response to lipopolysaccharide
C0071345biological_processcellular response to cytokine stimulus
C0071526biological_processsemaphorin-plexin signaling pathway
C0071803biological_processpositive regulation of podosome assembly
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0071944cellular_componentcell periphery
C0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
C0090307biological_processmitotic spindle assembly
C0090324biological_processnegative regulation of oxidative phosphorylation
C0097049biological_processmotor neuron apoptotic process
C0097498biological_processendothelial tube lumen extension
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0101003cellular_componentficolin-1-rich granule membrane
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1902766biological_processskeletal muscle satellite cell migration
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C1903673biological_processmitotic cleavage furrow formation
C1904695biological_processpositive regulation of vascular associated smooth muscle contraction
C1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
C1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
C1990869biological_processcellular response to chemokine
C2000177biological_processregulation of neural precursor cell proliferation
C2000406biological_processpositive regulation of T cell migration
C2000672biological_processnegative regulation of motor neuron apoptotic process
F0000902biological_processcell morphogenesis
F0001764biological_processneuron migration
F0001822biological_processkidney development
F0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
F0002363biological_processalpha-beta T cell lineage commitment
F0003100biological_processregulation of systemic arterial blood pressure by endothelin
F0003189biological_processaortic valve formation
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006357biological_processregulation of transcription by RNA polymerase II
F0007010biological_processcytoskeleton organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007264biological_processsmall GTPase-mediated signal transduction
F0007266biological_processRho protein signal transduction
F0007519biological_processskeletal muscle tissue development
F0009898cellular_componentcytoplasmic side of plasma membrane
F0010812biological_processnegative regulation of cell-substrate adhesion
F0010975biological_processregulation of neuron projection development
F0016477biological_processcell migration
F0016787molecular_functionhydrolase activity
F0017022molecular_functionmyosin binding
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0021795biological_processcerebral cortex cell migration
F0021861biological_processforebrain radial glial cell differentiation
F0030027cellular_componentlamellipodium
F0030036biological_processactin cytoskeleton organization
F0030054cellular_componentcell junction
F0030154biological_processcell differentiation
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030496cellular_componentmidbody
F0030521biological_processandrogen receptor signaling pathway
F0030667cellular_componentsecretory granule membrane
F0031122biological_processcytoplasmic microtubule organization
F0031982cellular_componentvesicle
F0032154cellular_componentcleavage furrow
F0032467biological_processpositive regulation of cytokinesis
F0032587cellular_componentruffle membrane
F0032956biological_processregulation of actin cytoskeleton organization
F0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
F0033688biological_processregulation of osteoblast proliferation
F0034329biological_processcell junction assembly
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035385biological_processRoundabout signaling pathway
F0036089biological_processcleavage furrow formation
F0038027biological_processapolipoprotein A-I-mediated signaling pathway
F0042476biological_processodontogenesis
F0042995cellular_componentcell projection
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043149biological_processstress fiber assembly
F0043197cellular_componentdendritic spine
F0043296cellular_componentapical junction complex
F0043297biological_processapical junction assembly
F0043366biological_processbeta selection
F0043542biological_processendothelial cell migration
F0043931biological_processossification involved in bone maturation
F0044319biological_processwound healing, spreading of cells
F0045198biological_processestablishment of epithelial cell apical/basal polarity
F0045666biological_processpositive regulation of neuron differentiation
F0045792biological_processnegative regulation of cell size
F0046638biological_processpositive regulation of alpha-beta T cell differentiation
F0050919biological_processnegative chemotaxis
F0051301biological_processcell division
F0051496biological_processpositive regulation of stress fiber assembly
F0051893biological_processregulation of focal adhesion assembly
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060193biological_processpositive regulation of lipase activity
F0061430biological_processbone trabecula morphogenesis
F0070062cellular_componentextracellular exosome
F0070507biological_processregulation of microtubule cytoskeleton organization
F0071222biological_processcellular response to lipopolysaccharide
F0071345biological_processcellular response to cytokine stimulus
F0071526biological_processsemaphorin-plexin signaling pathway
F0071803biological_processpositive regulation of podosome assembly
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0071944cellular_componentcell periphery
F0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
F0090307biological_processmitotic spindle assembly
F0090324biological_processnegative regulation of oxidative phosphorylation
F0097049biological_processmotor neuron apoptotic process
F0097498biological_processendothelial tube lumen extension
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099159biological_processregulation of modification of postsynaptic structure
F0101003cellular_componentficolin-1-rich granule membrane
F1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
F1902766biological_processskeletal muscle satellite cell migration
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903673biological_processmitotic cleavage furrow formation
F1904695biological_processpositive regulation of vascular associated smooth muscle contraction
F1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
F1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
F1990869biological_processcellular response to chemokine
F2000177biological_processregulation of neural precursor cell proliferation
F2000406biological_processpositive regulation of T cell migration
F2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG F 201
ChainResidue
FTHR19
FTHR37
FGSP202
FHOH349
FHOH364

site_idAC2
Number of Residues27
Detailsbinding site for residue GSP F 202
ChainResidue
FLYS18
FTHR19
FCYS20
FPHE30
FTYR34
FPRO36
FTHR37
FGLY62
FLYS118
FASP120
FSER160
FALA161
FLYS162
FMG201
FHOH308
FHOH335
FHOH345
FHOH349
FHOH355
FHOH362
FHOH364
FHOH378
FHOH416
CPHE154
FALA15
FCYS16
FGLY17

site_idAC3
Number of Residues5
Detailsbinding site for residue MG C 201
ChainResidue
CTHR19
CTHR37
CGSP202
CHOH332
CHOH340

site_idAC4
Number of Residues29
Detailsbinding site for residue GSP C 202
ChainResidue
CALA15
CCYS16
CGLY17
CLYS18
CTHR19
CCYS20
CPHE30
CTYR34
CPRO36
CTHR37
CGLY62
CLYS118
CASP120
CLEU121
CSER160
CALA161
CLYS162
CMG201
CHOH322
CHOH326
CHOH332
CHOH340
CHOH349
CHOH364
CHOH373
CHOH392
CHOH408
FPHE154
FHOH447

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
FGLY12
FASN117
CGLY12
CASN117

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
FPHE30
FASP59
FSER160
CPHE30
CASP59
CSER160

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
FTYR34
CTYR34

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
FTHR37
CTHR37

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
FASN41
CASN41

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
FGLN63
CGLN63

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
FTYR34
CTYR34

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
FTHR37
CTHR37

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
FLYS135
CLYS135

222926

PDB entries from 2024-07-24

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