6BBI
The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | THR164-LEU181 | |
| A | LEU192-ILE212 | |
| A | ALA249-VAL269 | |
| A | ALA278-ILE298 | |
| B | THR164-LEU181 | |
| B | LEU192-ILE212 | |
| B | ALA249-VAL269 | |
| B | ALA278-ILE298 | |
| C | THR164-LEU181 | |
| C | LEU192-ILE212 | |
| C | ALA249-VAL269 | |
| C | ALA278-ILE298 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP182-MET191 | |
| A | LYS270-PRO277 | |
| B | ASP182-MET191 | |
| B | LYS270-PRO277 | |
| C | ASP182-MET191 | |
| C | LYS270-PRO277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 105 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | SER213-TRP248 | |
| B | SER213-TRP248 | |
| C | SER213-TRP248 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Confers selective permeability to Ca(2+) ions => ECO:0000250|UniProtKB:Q96D31, ECO:0000305|PubMed:16921383 |
| Chain | Residue | Details |
| A | GLU178 | |
| B | GLU178 | |
| C | GLU178 |
