6BB4

Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope.

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 H 301

Chain	Residue
H	TYR27
H	THR28
H	ASP31
H	ARG32
H	THR83
H	HOH437

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 I 301

Chain	Residue
I	ARG32
I	THR83
I	TYR27
I	THR28
I	ASP31

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 J 301

Chain	Residue
J	TYR27
J	THR28
J	ASP31
J	ARG32
J	THR83

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by CK1 and PDPK1","evidences":[{"source":"PubMed","id":"14761950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15546861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1899488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19451179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21327254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9614189","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---