6BB4
Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 H 301 |
| Chain | Residue |
| H | TYR27 |
| H | THR28 |
| H | ASP31 |
| H | ARG32 |
| H | THR83 |
| H | HOH437 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 I 301 |
| Chain | Residue |
| I | ARG32 |
| I | THR83 |
| I | TYR27 |
| I | THR28 |
| I | ASP31 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 J 301 |
| Chain | Residue |
| J | TYR27 |
| J | THR28 |
| J | ASP31 |
| J | ARG32 |
| J | THR83 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| P | LYS395 | |
| Q | LYS395 | |
| R | LYS395 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | TYR394 | |
| Q | TYR394 | |
| R | TYR394 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SEP396 | |
| Q | SEP396 | |
| R | SEP396 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 | |
| R | SER400 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | THR403 | |
| Q | THR403 | |
| R | THR403 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SEP404 | |
| Q | SEP404 | |
| R | SEP404 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 | |
| R | SER400 |
