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6BAB

The structure of human CamKII with bound inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue D0S A 401
ChainResidue
ALEU21
AGLU141
AASN142
ALEU144
AASP158
AHOH571
AGLY22
ALYS23
AVAL29
AALA42
APHE91
AASP92
AVAL94
AGLU98

site_idAC2
Number of Residues8
Detailsbinding site for residue TLA A 402
ChainResidue
AGLN119
AILE273
ACYS274
AGLN275
AARG276
ASER277
AHOH687
CLEU301

site_idAC3
Number of Residues14
Detailsbinding site for residue D0S B 401
ChainResidue
BLEU21
BVAL29
BALA42
BPHE91
BASP92
BLEU93
BVAL94
BGLU141
BASN142
BLEU144
BASP158
BHOH502
BHOH529
BHOH568

site_idAC4
Number of Residues8
Detailsbinding site for residue TLA B 402
ChainResidue
BGLN119
BILE273
BCYS274
BGLN275
BARG276
BSER277
BHOH534
BHOH605

site_idAC5
Number of Residues15
Detailsbinding site for residue D0S C 401
ChainResidue
CLEU21
CLYS23
CVAL29
CALA42
CPHE91
CASP92
CLEU93
CVAL94
CGLY97
CGLU98
CGLU141
CASN142
CLEU144
CASP158
CHOH580

site_idAC6
Number of Residues9
Detailsbinding site for residue TLA C 402
ChainResidue
ALEU301
CGLN119
CILE273
CCYS274
CGLN275
CARG276
CSER277
CHOH514
CHOH522

site_idAC7
Number of Residues19
Detailsbinding site for residue D0S D 401
ChainResidue
DLEU22
DGLY23
DLYS24
DVAL30
DALA43
DPHE92
DASP93
DLEU94
DVAL95
DGLY98
DGLU142
DASN143
DLEU145
DASP159
DHOH504
DHOH505
DHOH535
DHOH566
DHOH643

site_idAC8
Number of Residues5
Detailsbinding site for Di-peptide PHE D 12 and THR D 13
ChainResidue
CGLN169
DARG11
DASP14
DGLU15
DGLU84

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFSVVRrCmkiptgqe..........YAAK
ChainResidueDetails
ALEU21-LYS44

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLL
ChainResidueDetails
AILE133-LEU145

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues516
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues36
DetailsRegion: {"description":"Autoinhibitory domain","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q13557","evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues10
DetailsRegion: {"description":"Calmodulin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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