6B9F

Human ATL1 mutant - F151S bound to GDPAlF4-

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 501

Chain	Residue
A	THR108
A	GLY109
A	PHE110
A	SER111
A	TRP112
A	HOH664
A	HOH761

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	HOH676
A	TYR92
A	THR108

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 503

Chain	Residue
A	GLU372
A	GLN431
A	TYR432
A	HIS435
B	GLU372
B	GLN431
B	TYR432
B	HIS435

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 504

Chain	Residue
A	SER265
A	TRP303
A	HOH611

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 505

Chain	Residue
A	SER81
A	THR120
A	GDP506
A	ALF507
A	HOH663
A	HOH677

---

site_id	AC6
Number of Residues	21
Details	binding site for residue GDP A 506

Chain	Residue
A	ARG77
A	LYS78
A	GLY79
A	LYS80
A	SER81
A	PHE82
A	TRP112
A	ARG113
A	GLY114
A	ARG217
A	ASP218
A	PRO272
A	VAL276
A	PHE282
A	MG505
A	ALF507
A	HOH663
A	HOH677
A	HOH681
A	HOH689
B	HOH766

---

site_id	AC7
Number of Residues	11
Details	binding site for residue ALF A 507

Chain	Residue
A	PHE76
A	ARG77
A	LYS80
A	ARG118
A	GLU119
A	THR120
A	GLY149
A	MG505
A	GDP506
A	HOH658
A	HOH663

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL B 501

Chain	Residue
B	GLN36
B	SER111
B	GLU119
B	THR120
B	THR121
B	GLN124
B	HOH637

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL B 502

Chain	Residue
B	THR108
B	GLY109
B	PHE110
B	SER111
B	TRP112
B	GOL503
B	HOH603
B	HOH698

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL B 503

Chain	Residue
B	TRP112
B	SER243
B	GLY244
B	PHE282
B	GOL502
B	HOH636

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL B 504

Chain	Residue
B	TYR92
B	THR108
B	GLY109

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MG B 505

Chain	Residue
B	SER81
B	THR120
B	GDP506
B	ALF507
B	HOH665
B	HOH681

---

site_id	AD4
Number of Residues	22
Details	binding site for residue GDP B 506

Chain	Residue
B	ASP218
B	PRO272
B	VAL276
B	PHE282
B	MG505
B	ALF507
B	HOH649
B	HOH665
B	HOH668
B	HOH681
B	HOH687
B	HOH779
B	ARG77
B	LYS78
B	GLY79
B	LYS80
B	SER81
B	PHE82
B	TRP112
B	ARG113
B	GLY114
B	ARG217

---

site_id	AD5
Number of Residues	12
Details	binding site for residue ALF B 507

Chain	Residue
B	PHE76
B	ARG77
B	LYS80
B	ARG118
B	GLU119
B	THR120
B	GLY149
B	MG505
B	GDP506
B	HOH646
B	HOH665
B	HOH681

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	Domain: {"description":"GB1/RHD3-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01052","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21220294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21368113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23334294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34546351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38509071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	182
Details	Region: {"description":"3HB (three-helix bundle) domain","evidences":[{"source":"PubMed","id":"21220294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21368113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23334294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34546351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38509071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23334294","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4IDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21220294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21368113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3Q5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QNU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QOF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"6XJN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21220294","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21368113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34546351","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3Q5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3Q5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QNU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QOF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q6DD88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Region: {"description":"Linker","evidences":[{"source":"PubMed","id":"38509071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---