Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6B58

FrdA-SdhE assembly intermediate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000104	molecular_function	succinate dehydrogenase activity
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006113	biological_process	fermentation
A	0006974	biological_process	DNA damage response
A	0008177	molecular_function	succinate dehydrogenase (quinone) activity
A	0009055	molecular_function	electron transfer activity
A	0009061	biological_process	anaerobic respiration
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0019645	biological_process	anaerobic electron transport chain
A	0022900	biological_process	electron transport chain
A	0044780	biological_process	bacterial-type flagellum assembly
A	0045284	cellular_component	obsolete plasma membrane fumarate reductase complex
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0071949	molecular_function	FAD binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006105	biological_process	succinate metabolic process
B	0034552	biological_process	respiratory chain complex II assembly
C	0000104	molecular_function	succinate dehydrogenase activity
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006113	biological_process	fermentation
C	0006974	biological_process	DNA damage response
C	0008177	molecular_function	succinate dehydrogenase (quinone) activity
C	0009055	molecular_function	electron transfer activity
C	0009061	biological_process	anaerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0019645	biological_process	anaerobic electron transport chain
C	0022900	biological_process	electron transport chain
C	0044780	biological_process	bacterial-type flagellum assembly
C	0045284	cellular_component	obsolete plasma membrane fumarate reductase complex
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0071949	molecular_function	FAD binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006105	biological_process	succinate metabolic process
D	0034552	biological_process	respiratory chain complex II assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FAD A 601

Chain	Residue
A	GLY11
A	HIS44
A	THR45
A	ALA48
A	GLU49
A	HIS155
A	VAL157
A	ALA191
A	THR192
A	GLY193
A	THR203
A	ALA12
A	ASN204
A	ASP211
A	TYR356
A	GLY378
A	GLU379
A	ARG390
A	SER393
A	SER395
A	LEU396
A	LEU399
A	GLY13
A	ACT609
A	HOH702
A	GLY14
A	ALA15
A	SER36
A	LYS37
A	VAL38
A	SER43

site_id	AC2
Number of Residues	6
Details	binding site for residue K A 602

Chain	Residue
A	TYR356
A	THR357
A	MET358
A	GLY359
A	GLU379
A	SER381

site_id	AC3
Number of Residues	2
Details	binding site for residue ACT A 603

Chain	Residue
A	TYR84
A	ASN366

site_id	AC4
Number of Residues	1
Details	binding site for residue ACT A 604

Chain	Residue
A	GLN145

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 605

Chain	Residue
A	LEU548
A	ASP567
A	VAL568

site_id	AC6
Number of Residues	3
Details	binding site for residue ACT A 606

Chain	Residue
A	GLU63
A	ASP83
A	THR572

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT A 607

Chain	Residue
A	GLY72
A	ARG287
A	ASN389
A	ARG390
A	LEU391

site_id	AC8
Number of Residues	5
Details	binding site for residue ACT A 608

Chain	Residue
A	GLU537
A	GLY538
A	THR540
A	GLU541
C	ARG299

site_id	AC9
Number of Residues	3
Details	binding site for residue ACT A 609

Chain	Residue
A	HIS355
A	ARG390
A	FAD601

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 610

Chain	Residue
A	ARG18
A	ALA22
A	GLN25
A	ARG404
A	GLU408

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 611

Chain	Residue
A	ARG299
A	LEU471

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO A 612

Chain	Residue
A	HIS510
A	ASN513

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 613

Chain	Residue
A	LEU391
A	GLY392
A	SER393

site_id	AD5
Number of Residues	5
Details	binding site for residue K C 602

Chain	Residue
C	THR357
C	MET358
C	GLY359
C	GLU379
C	SER381

site_id	AD6
Number of Residues	5
Details	binding site for residue PEG C 603

Chain	Residue
C	LEU158
C	ASP159
C	SER218
C	ILE506
C	HIS510

site_id	AD7
Number of Residues	6
Details	binding site for residue MLI C 604

Chain	Residue
C	GLY50
C	ARG287
C	HIS355
C	ARG390
C	GLY392
C	FAD601

site_id	AD8
Number of Residues	3
Details	binding site for residue GOL C 605

Chain	Residue
C	PRO147
C	ILE149
C	ARG151

site_id	AD9
Number of Residues	2
Details	binding site for residue ACT C 606

Chain	Residue
C	GLN4
C	ASP6

site_id	AE1
Number of Residues	1
Details	binding site for residue ACT C 607

Chain	Residue
C	ASN366

site_id	AE2
Number of Residues	5
Details	binding site for residue ACT C 608

Chain	Residue
C	TYR266
C	LYS289
C	GLN292
C	HIS296
C	TYR466

site_id	AE3
Number of Residues	4
Details	binding site for residue ACT C 609

Chain	Residue
C	GLU63
C	ASP83
C	HIS87
C	PHE62

site_id	AE4
Number of Residues	33
Details	binding site for Di-peptide FAD C 601 and HIS C 44

Chain	Residue
C	GLY11
C	ALA12
C	GLY13
C	GLY14
C	ALA15
C	SER36
C	LYS37
C	VAL38
C	SER43
C	THR45
C	VAL46
C	ALA47
C	ALA48
C	GLY50
C	HIS155
C	VAL157
C	ALA191
C	THR192
C	GLY193
C	ASN204
C	ASP211
C	TYR356
C	GLY378
C	GLU379
C	ARG390
C	SER393
C	SER395
C	LEU396
C	LEU399
C	MLI604
C	HOH709
C	HOH710
D	GLY16

site_id	AE5
Number of Residues	4
Details	binding site for Di-peptide ALA D 7 and PBF D 8

Chain	Residue
C	MET176
C	THR500
D	ILE9
D	HIS10

site_id	AE6
Number of Residues	5
Details	binding site for Di-peptide PBF D 8 and ILE D 9

Chain	Residue
C	MET176
D	ALA7
D	HIS10
D	TRP11
D	ALA12

Functional Information from PROSITE/UniProt

site_id	PS00504
Number of Residues	10
Details	FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAeGG

Chain	Residue	Details
A	ARG42-GLY51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:1856194

Chain	Residue	Details
A	HIS232
A	ARG248
C	HIS232
C	ARG248

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0007744\|PDB:1KF6, ECO:0007744\|PDB:1KFY, ECO:0007744\|PDB:1L0V

Chain	Residue	Details
A	GLY11
C	SER43
C	HIS155
C	ASP211
C	GLU379
C	ARG390
A	ILE35
A	SER43
A	HIS155
A	ASP211
A	GLU379
A	ARG390
C	GLY11
C	ILE35

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:1KF6

Chain	Residue	Details
A	ALA191
C	ALA191

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:2B76, ECO:0007744\|PDB:3CIR

Chain	Residue	Details
A	HIS355
C	HIS355

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Tele-8alpha-FAD histidine => ECO:0000269\|PubMed:10373108, ECO:0007744\|PDB:1L0V

Chain	Residue	Details
A	HIS44
C	HIS44

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)