6B0B

Crystal structure of human APOBEC3H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0010526	biological_process	retrotransposon silencing
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0044828	biological_process	negative regulation by host of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
D	0006091	biological_process	generation of precursor metabolites and energy
D	0008218	biological_process	bioluminescence
E	0000932	cellular_component	P-body
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0004126	molecular_function	cytidine deaminase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008270	molecular_function	zinc ion binding
E	0010526	biological_process	retrotransposon silencing
E	0016554	biological_process	cytidine to uridine editing
E	0016787	molecular_function	hydrolase activity
E	0044355	biological_process	clearance of foreign intracellular DNA
E	0044828	biological_process	negative regulation by host of viral genome replication
E	0045087	biological_process	innate immune response
E	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
E	0046872	molecular_function	metal ion binding
E	0051607	biological_process	defense response to virus
E	0070383	biological_process	DNA cytosine deamination
H	0006091	biological_process	generation of precursor metabolites and energy
H	0008218	biological_process	bioluminescence

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEicFIneiksmgldetqcyqvtcyltws..........PCss......CaweL

Chain	Residue	Details
A	HIS54-LEU92

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:29290613, ECO:0007744|PDB:6B0B, ECO:0007744|PDB:6BBO

Chain	Residue	Details
A	GLU56
E	GLU56

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:29290613, ECO:0007744|PDB:6B0B, ECO:0007744|PDB:6BBO

Chain	Residue	Details
A	HIS54
A	CYS85
A	CYS88
E	HIS54
E	CYS85
E	CYS88

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