6AX3
Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 2MR A 501 |
| Chain | Residue |
| A | GLU238 |
| A | ZN503 |
| A | HOH614 |
| A | HOH667 |
| A | GLN275 |
| A | TRP310 |
| A | ILE317 |
| A | SER318 |
| A | HIS321 |
| A | ASP323 |
| A | TRP414 |
| A | AKG502 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue AKG A 502 |
| Chain | Residue |
| A | TYR272 |
| A | TRP310 |
| A | SER318 |
| A | HIS321 |
| A | ASP323 |
| A | ASN327 |
| A | LYS336 |
| A | HIS400 |
| A | VAL402 |
| A | SER412 |
| A | TRP414 |
| A | 2MR501 |
| A | ZN503 |
| A | HOH621 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 503 |
| Chain | Residue |
| A | HIS321 |
| A | ASP323 |
| A | HIS400 |
| A | 2MR501 |
| A | AKG502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29459673 |
| Chain | Residue | Details |
| A | LEU200 | |
| A | VAL237 | |
| A | ASP280 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ, ECO:0007744|PDB:4QU1, ECO:0007744|PDB:5FBJ |
| Chain | Residue | Details |
| A | THR234 | |
| A | ILE289 | |
| A | GLY298 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:22851697, ECO:0000305|PubMed:24100311, ECO:0007744|PDB:4GJY, ECO:0007744|PDB:4GJZ |
| Chain | Residue | Details |
| A | PRO283 | |
| A | LEU285 | |
| A | GLN362 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22851697, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0007744|PDB:3UYJ, ECO:0007744|PDB:4GJZ |
| Chain | Residue | Details |
| A | PHE376 |
