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6AW8

2.25A resolution domain swapped dimer structure of SAH bound catechol O-methyltransferase (COMT) from Nannospalax galili

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0005886cellular_componentplasma membrane
A0006584biological_processcatecholamine metabolic process
A0008168molecular_functionmethyltransferase activity
A0008171molecular_functionO-methyltransferase activity
A0016020cellular_componentmembrane
A0016206molecular_functioncatechol O-methyltransferase activity
A0016740molecular_functiontransferase activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032259biological_processmethylation
A0032502biological_processdevelopmental process
A0042417biological_processdopamine metabolic process
A0042424biological_processcatecholamine catabolic process
A0046872molecular_functionmetal ion binding
A0102084molecular_functionobsolete L-dopa O-methyltransferase activity
A0102938molecular_functionobsolete orcinol O-methyltransferase activity
B0000287molecular_functionmagnesium ion binding
B0005886cellular_componentplasma membrane
B0006584biological_processcatecholamine metabolic process
B0008168molecular_functionmethyltransferase activity
B0008171molecular_functionO-methyltransferase activity
B0016020cellular_componentmembrane
B0016206molecular_functioncatechol O-methyltransferase activity
B0016740molecular_functiontransferase activity
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032259biological_processmethylation
B0032502biological_processdevelopmental process
B0042417biological_processdopamine metabolic process
B0042424biological_processcatecholamine catabolic process
B0046872molecular_functionmetal ion binding
B0102084molecular_functionobsolete L-dopa O-methyltransferase activity
B0102938molecular_functionobsolete orcinol O-methyltransferase activity
C0000287molecular_functionmagnesium ion binding
C0005886cellular_componentplasma membrane
C0006584biological_processcatecholamine metabolic process
C0008168molecular_functionmethyltransferase activity
C0008171molecular_functionO-methyltransferase activity
C0016020cellular_componentmembrane
C0016206molecular_functioncatechol O-methyltransferase activity
C0016740molecular_functiontransferase activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0032259biological_processmethylation
C0032502biological_processdevelopmental process
C0042417biological_processdopamine metabolic process
C0042424biological_processcatecholamine catabolic process
C0046872molecular_functionmetal ion binding
C0102084molecular_functionobsolete L-dopa O-methyltransferase activity
C0102938molecular_functionobsolete orcinol O-methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 301
ChainResidue
AASP140
AASP168
AASN169
AHOH431
AHOH455
AHOH462

site_idAC2
Number of Residues19
Detailsbinding site for residue SAH A 302
ChainResidue
AALA67
ATYR68
ATYR71
ASER72
AGLU90
ALYS91
ATYR95
AGLY117
AALA118
ASER119
AGLN120
AASP140
AHIS141
ATRP142
AHOH403
AHOH415
AMET40
AVAL42
AGLY66

site_idAC3
Number of Residues6
Detailsbinding site for residue CA B 301
ChainResidue
BASP140
BASP168
BASN169
BHOH413
BHOH427
BHOH430

site_idAC4
Number of Residues20
Detailsbinding site for residue SAH B 302
ChainResidue
BMET40
BASN41
BVAL42
BGLY66
BALA67
BTYR68
BTYR71
BSER72
BGLU90
BLYS91
BTYR95
BGLY117
BALA118
BSER119
BGLN120
BASP140
BHIS141
BTRP142
BHOH406
BHOH413

site_idAC5
Number of Residues7
Detailsbinding site for residue CA C 301
ChainResidue
CASP140
CASP168
CASN169
CGLU198
CHOH414
CHOH425
CHOH431

site_idAC6
Number of Residues19
Detailsbinding site for residue SAH C 302
ChainResidue
CMET40
CVAL42
CGLY66
CALA67
CTYR68
CTYR71
CSER72
CGLU90
CLYS91
CTYR95
CGLY117
CALA118
CSER119
CGLN120
CASP140
CHIS141
CTRP142
CHOH402
CHOH419

218853

PDB entries from 2024-04-24

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