6AUN
calcium-independent phospholipase A2 beta
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| A | 0004622 | molecular_function | phosphatidylcholine lysophospholipase activity |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017171 | molecular_function | serine hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0031143 | cellular_component | pseudopodium |
| A | 0034638 | biological_process | phosphatidylcholine catabolic process |
| A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0035965 | biological_process | cardiolipin acyl-chain remodeling |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046338 | biological_process | phosphatidylethanolamine catabolic process |
| A | 0046469 | biological_process | platelet activating factor metabolic process |
| A | 0046473 | biological_process | phosphatidic acid metabolic process |
| A | 0047499 | molecular_function | calcium-independent phospholipase A2 activity |
| A | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
| A | 2000304 | biological_process | positive regulation of ceramide biosynthetic process |
| B | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| B | 0004622 | molecular_function | phosphatidylcholine lysophospholipase activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017171 | molecular_function | serine hydrolase activity |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0031143 | cellular_component | pseudopodium |
| B | 0034638 | biological_process | phosphatidylcholine catabolic process |
| B | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0035965 | biological_process | cardiolipin acyl-chain remodeling |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046338 | biological_process | phosphatidylethanolamine catabolic process |
| B | 0046469 | biological_process | platelet activating factor metabolic process |
| B | 0046473 | biological_process | phosphatidic acid metabolic process |
| B | 0047499 | molecular_function | calcium-independent phospholipase A2 activity |
| B | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
| B | 2000304 | biological_process | positive regulation of ceramide biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"ANK 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"ANK 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AUN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 368 |
| Details | Domain: {"description":"PNPLA","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | Region: {"description":"Calmodulin-binding (1-9-14 motif)","evidences":[{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Region: {"description":"Calmodulin-binding (IQ motif)","evidences":[{"source":"PubMed","id":"29472584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | Motif: {"description":"GXGXXG","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Motif: {"description":"GXSXG","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Motif: {"description":"DGA/G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01161","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
