6AU5

Structure of cetuximab with aminoheptanoic acid-linked n-butylarginine meditope variant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0003823	molecular_function	antigen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0016064	biological_process	immunoglobulin mediated immune response
A	0019814	cellular_component	immunoglobulin complex
A	0050853	biological_process	B cell receptor signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0071735	cellular_component	IgG immunoglobulin complex
A	0071738	cellular_component	IgD immunoglobulin complex
A	0071742	cellular_component	IgE immunoglobulin complex
A	0071745	cellular_component	IgA immunoglobulin complex
A	0071753	cellular_component	IgM immunoglobulin complex
A	0072562	cellular_component	blood microparticle
C	0002250	biological_process	adaptive immune response
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0016064	biological_process	immunoglobulin mediated immune response
C	0019814	cellular_component	immunoglobulin complex
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071735	cellular_component	IgG immunoglobulin complex
C	0071738	cellular_component	IgD immunoglobulin complex
C	0071742	cellular_component	IgE immunoglobulin complex
C	0071745	cellular_component	IgA immunoglobulin complex
C	0071753	cellular_component	IgM immunoglobulin complex
C	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 B 301

Chain	Residue
B	PHE27
B	SER28
B	ASN31
B	TYR32
B	HOH402

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site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 C 301

Chain	Residue
C	HOH452
C	SER156
C	GLY157
C	HOH433
C	HOH436

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site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 D 301

Chain	Residue
D	PHE27
D	SER28
D	ASN31
D	TYR32

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site_id	AC4
Number of Residues	22
Details	binding site for Ligand residues BWV E 8 through ARG E 9 bound to THR E 7

Chain	Residue
A	GLN38
A	THR40
A	ASN41
A	GLY42
A	SER43
A	ALA84
A	ASP85
A	GLU165
A	HOH308
B	PRO9
B	ILE92
B	TYR94
B	GLN111
B	GLY112
B	LEU114
E	PHE3
E	ASP4
E	THR7
E	LEU10
E	LYS11
E	HOH101
E	HOH102

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site_id	AC5
Number of Residues	21
Details	binding site for Ligand residues BWV F 8 through ARG F 9 bound to THR F 7

Chain	Residue
C	GLN38
C	THR40
C	GLY42
C	SER43
C	ALA84
C	ASP85
C	LYS103
C	GLU165
C	HOH403
C	HOH411
D	PRO9
D	ILE92
D	TYR94
D	GLN111
D	GLY112
D	LEU114
F	PHE3
F	ASP4
F	SER6
F	THR7
F	LEU10

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR192-HIS198
B	TYR200-HIS206

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