6ASV

E. coli PRPP Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002189	cellular_component	ribose phosphate diphosphokinase complex
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0034214	biological_process	protein hexamerization
A	0042301	molecular_function	phosphate ion binding
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0044249	biological_process	cellular biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0002189	cellular_component	ribose phosphate diphosphokinase complex
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0034214	biological_process	protein hexamerization
B	0042301	molecular_function	phosphate ion binding
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0044249	biological_process	cellular biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0002189	cellular_component	ribose phosphate diphosphokinase complex
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0034214	biological_process	protein hexamerization
C	0042301	molecular_function	phosphate ion binding
C	0042802	molecular_function	identical protein binding
C	0043531	molecular_function	ADP binding
C	0044249	biological_process	cellular biosynthetic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PO4 A 401

Chain	Residue
A	ASP170
A	GLY172
A	GLY173
A	ASP220
A	ASP221

---

site_id	AC2
Number of Residues	7
Details	binding site for residue PO4 A 402

Chain	Residue
A	THR228
A	LEU229
A	HOH504
A	ASP224
A	THR225
A	GLY226
A	GLY227

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 403

Chain	Residue
A	ARG49
B	ARG105
C	ILE309

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 B 401

Chain	Residue
B	HIS131
B	ASP170
B	GLY172
B	GLY173
B	ASP220
B	ASP221

---

site_id	AC5
Number of Residues	7
Details	binding site for residue PO4 B 402

Chain	Residue
B	ILE223
B	ASP224
B	THR225
B	GLY226
B	GLY227
B	THR228
B	LEU229

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL B 403

Chain	Residue
A	ARG105
A	ILE309
B	ARG49

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PO4 C 401

Chain	Residue
C	HIS131
C	ASP170
C	ASP220
C	ASP221
C	HOH544

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PO4 C 402

Chain	Residue
C	MET222
C	ASP224
C	THR225
C	GLY226
C	THR228
C	LEU229

---

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. CVLVDDMIDTGgT

Chain	Residue	Details
A	CYS216-THR228

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site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAeQIQGFFdvPVD

Chain	Residue	Details
A	ASP129-ASP144

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7657655

Chain	Residue	Details
A	LYS194
B	LYS194
C	LYS194

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00583

Chain	Residue	Details
A	ASP37
B	HIS131
B	ASP170
B	ARG196
B	ASP220
B	ASP224
C	ASP37
C	ARG96
C	HIS131
C	ASP170
C	ARG196
A	ARG96
C	ASP220
C	ASP224
A	HIS131
A	ASP170
A	ARG196
A	ASP220
A	ASP224
B	ASP37
B	ARG96

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