6ARV
Crystal structure of CARM1 with Compound 2 and SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue SAH A 501 |
| Chain | Residue |
| A | TYR149 |
| A | LEU198 |
| A | GLU214 |
| A | ALA215 |
| A | GLY240 |
| A | LYS241 |
| A | VAL242 |
| A | GLU243 |
| A | GLU257 |
| A | MET268 |
| A | SER271 |
| A | PHE150 |
| A | BW7502 |
| A | HOH649 |
| A | HOH655 |
| A | HOH682 |
| A | HOH702 |
| A | TYR153 |
| A | GLN159 |
| A | MET162 |
| A | ARG168 |
| A | GLY192 |
| A | CYS193 |
| A | ILE197 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue BW7 A 502 |
| Chain | Residue |
| A | PHE152 |
| A | TYR153 |
| A | MET162 |
| A | GLU257 |
| A | MET259 |
| A | GLU266 |
| A | HIS414 |
| A | TRP415 |
| A | PHE474 |
| A | SAH501 |
| A | HOH654 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | TYR166 |
| A | GLY170 |
| A | THR171 |
| A | ARG174 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ASP392 |
| A | TRP403 |
| A | HOH623 |
| A | HOH751 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ASP165 |
| A | THR413 |
| A | HIS414 |
| A | TYR416 |
| A | HOH602 |
| A | HOH660 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | PRO408 |
| A | THR409 |
| A | GLU410 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue SAH B 501 |
| Chain | Residue |
| B | TYR149 |
| B | PHE150 |
| B | TYR153 |
| B | GLN159 |
| B | MET162 |
| B | ARG168 |
| B | GLY192 |
| B | CYS193 |
| B | GLY194 |
| B | ILE197 |
| B | LEU198 |
| B | GLU214 |
| B | ALA215 |
| B | GLY240 |
| B | LYS241 |
| B | VAL242 |
| B | GLU243 |
| B | MET268 |
| B | SER271 |
| B | BW7502 |
| B | HOH626 |
| B | HOH632 |
| B | HOH668 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue BW7 B 502 |
| Chain | Residue |
| B | TYR149 |
| B | PHE152 |
| B | TYR153 |
| B | MET162 |
| B | GLU257 |
| B | MET259 |
| B | TYR261 |
| B | GLU266 |
| B | HIS414 |
| B | TRP415 |
| B | SAH501 |
| B | HOH658 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | ASP392 |
| B | SER405 |
| B | HOH653 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | TYR314 |
| B | ARG327 |
| B | GLY328 |
| B | HOH729 |
| B | HOH747 |
| site_id | AD2 |
| Number of Residues | 24 |
| Details | binding site for residue SAH C 501 |
| Chain | Residue |
| C | ARG168 |
| C | GLY192 |
| C | CYS193 |
| C | GLY194 |
| C | ILE197 |
| C | LEU198 |
| C | GLU214 |
| C | ALA215 |
| C | GLY240 |
| C | LYS241 |
| C | VAL242 |
| C | GLU243 |
| C | GLU257 |
| C | MET268 |
| C | SER271 |
| C | BW7502 |
| C | HOH635 |
| C | HOH647 |
| C | HOH662 |
| C | HOH679 |
| C | TYR149 |
| C | TYR153 |
| C | GLN159 |
| C | MET162 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue BW7 C 502 |
| Chain | Residue |
| C | TYR149 |
| C | PHE152 |
| C | TYR153 |
| C | MET162 |
| C | GLU257 |
| C | MET259 |
| C | TYR261 |
| C | ASN265 |
| C | HIS414 |
| C | TRP415 |
| C | SAH501 |
| C | HOH637 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | TYR166 |
| C | VAL167 |
| C | GLY170 |
| C | THR171 |
| C | ARG174 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | ASP392 |
| C | HOH636 |
| site_id | AD6 |
| Number of Residues | 24 |
| Details | binding site for residue SAH D 501 |
| Chain | Residue |
| D | TYR149 |
| D | PHE150 |
| D | TYR153 |
| D | GLN159 |
| D | MET162 |
| D | ARG168 |
| D | GLY192 |
| D | CYS193 |
| D | ILE197 |
| D | LEU198 |
| D | GLU214 |
| D | ALA215 |
| D | GLY240 |
| D | LYS241 |
| D | VAL242 |
| D | GLU243 |
| D | GLU257 |
| D | MET268 |
| D | SER271 |
| D | BW7502 |
| D | HOH617 |
| D | HOH622 |
| D | HOH676 |
| D | HOH691 |
| site_id | AD7 |
| Number of Residues | 12 |
| Details | binding site for residue BW7 D 502 |
| Chain | Residue |
| D | TYR149 |
| D | PHE152 |
| D | TYR153 |
| D | MET162 |
| D | GLU257 |
| D | MET259 |
| D | TYR261 |
| D | GLU266 |
| D | HIS414 |
| D | TRP415 |
| D | SAH501 |
| D | HOH630 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| D | THR409 |
| D | GLU410 |
| D | PRO411 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 504 |
| Chain | Residue |
| D | ALA350 |
| D | LYS351 |
| D | SER352 |
| D | TRP390 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 505 |
| Chain | Residue |
| D | LYS186 |
| D | ASP252 |
| D | PRO281 |
| D | SER282 |
| D | GLY283 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1228 |
| Details | Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Region: {"description":"Required for nuclear translocation","evidences":[{"source":"UniProtKB","id":"Q9WVG6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21410432","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34480022","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
