6ARV
Crystal structure of CARM1 with Compound 2 and SAH
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
A | 0018216 | biological_process | peptidyl-arginine methylation |
B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
B | 0018216 | biological_process | peptidyl-arginine methylation |
C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
C | 0018216 | biological_process | peptidyl-arginine methylation |
D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue SAH A 501 |
Chain | Residue |
A | TYR149 |
A | LEU198 |
A | GLU214 |
A | ALA215 |
A | GLY240 |
A | LYS241 |
A | VAL242 |
A | GLU243 |
A | GLU257 |
A | MET268 |
A | SER271 |
A | PHE150 |
A | BW7502 |
A | HOH649 |
A | HOH655 |
A | HOH682 |
A | HOH702 |
A | TYR153 |
A | GLN159 |
A | MET162 |
A | ARG168 |
A | GLY192 |
A | CYS193 |
A | ILE197 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue BW7 A 502 |
Chain | Residue |
A | PHE152 |
A | TYR153 |
A | MET162 |
A | GLU257 |
A | MET259 |
A | GLU266 |
A | HIS414 |
A | TRP415 |
A | PHE474 |
A | SAH501 |
A | HOH654 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | TYR166 |
A | GLY170 |
A | THR171 |
A | ARG174 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | ASP392 |
A | TRP403 |
A | HOH623 |
A | HOH751 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASP165 |
A | THR413 |
A | HIS414 |
A | TYR416 |
A | HOH602 |
A | HOH660 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | PRO408 |
A | THR409 |
A | GLU410 |
site_id | AC7 |
Number of Residues | 23 |
Details | binding site for residue SAH B 501 |
Chain | Residue |
B | TYR149 |
B | PHE150 |
B | TYR153 |
B | GLN159 |
B | MET162 |
B | ARG168 |
B | GLY192 |
B | CYS193 |
B | GLY194 |
B | ILE197 |
B | LEU198 |
B | GLU214 |
B | ALA215 |
B | GLY240 |
B | LYS241 |
B | VAL242 |
B | GLU243 |
B | MET268 |
B | SER271 |
B | BW7502 |
B | HOH626 |
B | HOH632 |
B | HOH668 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residue BW7 B 502 |
Chain | Residue |
B | TYR149 |
B | PHE152 |
B | TYR153 |
B | MET162 |
B | GLU257 |
B | MET259 |
B | TYR261 |
B | GLU266 |
B | HIS414 |
B | TRP415 |
B | SAH501 |
B | HOH658 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | ASP392 |
B | SER405 |
B | HOH653 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue GOL B 504 |
Chain | Residue |
B | TYR314 |
B | ARG327 |
B | GLY328 |
B | HOH729 |
B | HOH747 |
site_id | AD2 |
Number of Residues | 24 |
Details | binding site for residue SAH C 501 |
Chain | Residue |
C | ARG168 |
C | GLY192 |
C | CYS193 |
C | GLY194 |
C | ILE197 |
C | LEU198 |
C | GLU214 |
C | ALA215 |
C | GLY240 |
C | LYS241 |
C | VAL242 |
C | GLU243 |
C | GLU257 |
C | MET268 |
C | SER271 |
C | BW7502 |
C | HOH635 |
C | HOH647 |
C | HOH662 |
C | HOH679 |
C | TYR149 |
C | TYR153 |
C | GLN159 |
C | MET162 |
site_id | AD3 |
Number of Residues | 12 |
Details | binding site for residue BW7 C 502 |
Chain | Residue |
C | TYR149 |
C | PHE152 |
C | TYR153 |
C | MET162 |
C | GLU257 |
C | MET259 |
C | TYR261 |
C | ASN265 |
C | HIS414 |
C | TRP415 |
C | SAH501 |
C | HOH637 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue GOL C 503 |
Chain | Residue |
C | TYR166 |
C | VAL167 |
C | GLY170 |
C | THR171 |
C | ARG174 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue GOL C 504 |
Chain | Residue |
C | ASP392 |
C | HOH636 |
site_id | AD6 |
Number of Residues | 24 |
Details | binding site for residue SAH D 501 |
Chain | Residue |
D | TYR149 |
D | PHE150 |
D | TYR153 |
D | GLN159 |
D | MET162 |
D | ARG168 |
D | GLY192 |
D | CYS193 |
D | ILE197 |
D | LEU198 |
D | GLU214 |
D | ALA215 |
D | GLY240 |
D | LYS241 |
D | VAL242 |
D | GLU243 |
D | GLU257 |
D | MET268 |
D | SER271 |
D | BW7502 |
D | HOH617 |
D | HOH622 |
D | HOH676 |
D | HOH691 |
site_id | AD7 |
Number of Residues | 12 |
Details | binding site for residue BW7 D 502 |
Chain | Residue |
D | TYR149 |
D | PHE152 |
D | TYR153 |
D | MET162 |
D | GLU257 |
D | MET259 |
D | TYR261 |
D | GLU266 |
D | HIS414 |
D | TRP415 |
D | SAH501 |
D | HOH630 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue GOL D 503 |
Chain | Residue |
D | THR409 |
D | GLU410 |
D | PRO411 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue GOL D 504 |
Chain | Residue |
D | ALA350 |
D | LYS351 |
D | SER352 |
D | TRP390 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue GOL D 505 |
Chain | Residue |
D | LYS186 |
D | ASP252 |
D | PRO281 |
D | SER282 |
D | GLY283 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000305|PubMed:21410432 |
Chain | Residue | Details |
A | GLN159 | |
B | GLU214 | |
B | GLU243 | |
B | SER271 | |
C | GLN159 | |
C | ARG168 | |
C | GLY192 | |
C | GLU214 | |
C | GLU243 | |
C | SER271 | |
D | GLN159 | |
A | ARG168 | |
D | ARG168 | |
D | GLY192 | |
D | GLU214 | |
D | GLU243 | |
D | SER271 | |
A | GLY192 | |
A | GLU214 | |
A | GLU243 | |
A | SER271 | |
B | GLN159 | |
B | ARG168 | |
B | GLY192 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527 |
Chain | Residue | Details |
A | SER216 | |
B | SER216 | |
C | SER216 | |
D | SER216 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 |
Chain | Residue | Details |
A | LYS227 | |
B | LYS227 | |
C | LYS227 | |
D | LYS227 |