6AQP
Aspergillus fumigatus Cytosolic Thiolase: Acetylated enzyme in complex with CoA and potassium ions
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006635 | biological_process | fatty acid beta-oxidation |
A | 0006696 | biological_process | ergosterol biosynthetic process |
A | 0016126 | biological_process | sterol biosynthetic process |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0046872 | molecular_function | metal ion binding |
B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006635 | biological_process | fatty acid beta-oxidation |
B | 0006696 | biological_process | ergosterol biosynthetic process |
B | 0016126 | biological_process | sterol biosynthetic process |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0046872 | molecular_function | metal ion binding |
C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005829 | cellular_component | cytosol |
C | 0006635 | biological_process | fatty acid beta-oxidation |
C | 0006696 | biological_process | ergosterol biosynthetic process |
C | 0016126 | biological_process | sterol biosynthetic process |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0046872 | molecular_function | metal ion binding |
D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005829 | cellular_component | cytosol |
D | 0006635 | biological_process | fatty acid beta-oxidation |
D | 0006696 | biological_process | ergosterol biosynthetic process |
D | 0016126 | biological_process | sterol biosynthetic process |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | binding site for residue COA A 401 |
Chain | Residue |
A | SCY92 |
A | SER253 |
A | ALA324 |
A | PHE325 |
A | HIS354 |
A | HOH519 |
A | HOH533 |
A | HOH538 |
A | HOH573 |
A | HOH594 |
A | HOH646 |
A | LEU152 |
A | HOH743 |
A | HOH752 |
A | TYR187 |
A | ASN227 |
A | LEU228 |
A | ASN229 |
A | LYS232 |
A | ALA249 |
A | PRO250 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue K A 402 |
Chain | Residue |
A | TYR187 |
A | ALA249 |
A | PRO250 |
A | SER252 |
A | VAL350 |
A | HOH646 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue K A 403 |
Chain | Residue |
A | LEU41 |
A | VAL44 |
A | LEU47 |
A | HOH662 |
A | HOH788 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue K A 404 |
Chain | Residue |
A | ASP200 |
A | GLU201 |
A | ILE203 |
A | HOH787 |
A | HOH859 |
A | HOH860 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CL A 405 |
Chain | Residue |
A | ASN385 |
A | GLY389 |
A | HOH536 |
B | ARG71 |
B | HOH742 |
site_id | AC6 |
Number of Residues | 21 |
Details | binding site for residue COA B 401 |
Chain | Residue |
B | SCY92 |
B | LEU152 |
B | TYR187 |
B | ASN227 |
B | ASN229 |
B | LYS232 |
B | ILE236 |
B | PHE240 |
B | ALA249 |
B | PRO250 |
B | SER253 |
B | PHE294 |
B | ALA324 |
B | HIS354 |
B | HOH502 |
B | HOH524 |
B | HOH635 |
B | HOH640 |
B | HOH694 |
C | LYS137 |
C | HOH631 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue K B 402 |
Chain | Residue |
B | TYR187 |
B | ALA249 |
B | PRO250 |
B | SER252 |
B | VAL350 |
B | HOH640 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue K B 403 |
Chain | Residue |
B | ASP200 |
B | GLU201 |
B | ILE203 |
B | HOH618 |
B | HOH775 |
B | HOH813 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue K B 404 |
Chain | Residue |
B | LEU41 |
B | VAL44 |
B | LEU47 |
B | HOH729 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue CL B 405 |
Chain | Residue |
A | ARG71 |
A | HOH779 |
B | ASN385 |
B | GLY389 |
B | HOH504 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue K C 401 |
Chain | Residue |
C | TYR187 |
C | ALA249 |
C | PRO250 |
C | SER252 |
C | VAL350 |
C | HOH743 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue K C 402 |
Chain | Residue |
C | ASP200 |
C | GLU201 |
C | ILE203 |
C | HOH959 |
C | HOH996 |
C | HOH998 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue K C 403 |
Chain | Residue |
C | LEU47 |
C | HOH817 |
C | HOH929 |
C | HOH937 |
C | LEU41 |
C | VAL44 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue CL C 404 |
Chain | Residue |
C | ASN385 |
C | GLY387 |
C | GLY389 |
C | HOH544 |
D | ARG71 |
D | HOH876 |
site_id | AD6 |
Number of Residues | 28 |
Details | binding site for residue ACO C 405 |
Chain | Residue |
B | HOH657 |
C | SCY92 |
C | LEU152 |
C | MET161 |
C | TYR187 |
C | ASN227 |
C | ASN229 |
C | LYS232 |
C | LEU233 |
C | ILE236 |
C | ALA249 |
C | PRO250 |
C | SER253 |
C | PRO254 |
C | PHE294 |
C | ALA324 |
C | PHE325 |
C | HIS354 |
C | GLY386 |
C | HOH513 |
C | HOH515 |
C | HOH633 |
C | HOH724 |
C | HOH728 |
C | HOH734 |
C | HOH771 |
C | HOH773 |
C | HOH864 |
site_id | AD7 |
Number of Residues | 27 |
Details | binding site for residue COA D 401 |
Chain | Residue |
D | SCY92 |
D | LEU152 |
D | MET161 |
D | TYR187 |
D | ASN227 |
D | ASN229 |
D | LYS232 |
D | LEU233 |
D | ILE236 |
D | ALA249 |
D | PRO250 |
D | SER253 |
D | PRO254 |
D | PHE294 |
D | ALA324 |
D | PHE325 |
D | HOH512 |
D | HOH618 |
D | HOH659 |
D | HOH700 |
D | HOH726 |
D | HOH782 |
D | HOH792 |
D | HOH800 |
D | HOH818 |
D | HOH847 |
D | HOH858 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue K D 402 |
Chain | Residue |
D | TYR187 |
D | ALA249 |
D | PRO250 |
D | SER252 |
D | VAL350 |
D | HOH700 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue K D 403 |
Chain | Residue |
D | ASP200 |
D | GLU201 |
D | ILE203 |
D | HOH899 |
D | HOH977 |
D | HOH1002 |
D | HOH1061 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue K D 404 |
Chain | Residue |
D | LEU41 |
D | VAL44 |
D | LEU47 |
D | HOH785 |
D | HOH907 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue CL D 405 |
Chain | Residue |
C | ARG71 |
C | HOH816 |
D | ASN385 |
D | GLY387 |
D | GLY389 |
D | HOH621 |
Functional Information from PROSITE/UniProt
site_id | PS00053 |
Number of Residues | 18 |
Details | RIBOSOMAL_S8 Ribosomal protein S8 signature. GarILTTLlGVLkakkGK |
Chain | Residue | Details |
A | GLY360-LYS377 |
site_id | PS00098 |
Number of Residues | 19 |
Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNKvCASGLkAIilgaqtI |
Chain | Residue | Details |
A | VAL88-ILE106 |
site_id | PS00737 |
Number of Residues | 17 |
Details | THIOLASE_2 Thiolases signature 2. NlhGGaVAiGHPiGaSG |
Chain | Residue | Details |
A | ASN344-GLY360 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000250|UniProtKB:P24752 |
Chain | Residue | Details |
A | SCY92 | |
B | SCY92 | |
C | SCY92 | |
D | SCY92 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020 |
Chain | Residue | Details |
A | HIS354 | |
A | CYS384 | |
B | HIS354 | |
B | CYS384 | |
C | HIS354 | |
C | CYS384 | |
D | HIS354 | |
D | CYS384 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|DOI:10.1021/acscatal.7b02873, ECO:0007744|PDB:6AQP, ECO:0007744|PDB:6ARF, ECO:0007744|PDB:6ARG, ECO:0007744|PDB:6ARL, ECO:0007744|PDB:6ARR, ECO:0007744|PDB:6ART |
Chain | Residue | Details |
A | TYR187 | |
B | SER252 | |
B | VAL350 | |
B | ASN385 | |
C | TYR187 | |
C | ALA249 | |
C | PRO250 | |
C | SER252 | |
C | VAL350 | |
C | ASN385 | |
D | TYR187 | |
A | ALA249 | |
D | ALA249 | |
D | PRO250 | |
D | SER252 | |
D | VAL350 | |
D | ASN385 | |
A | PRO250 | |
A | SER252 | |
A | VAL350 | |
A | ASN385 | |
B | TYR187 | |
B | ALA249 | |
B | PRO250 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|DOI:10.1021/acscatal.7b02873, ECO:0007744|PDB:6ARE |
Chain | Residue | Details |
A | ASN229 | |
D | ASN229 | |
D | LYS232 | |
D | SER253 | |
A | LYS232 | |
A | SER253 | |
B | ASN229 | |
B | LYS232 | |
B | SER253 | |
C | ASN229 | |
C | LYS232 | |
C | SER253 |