6AQH

Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0003877	molecular_function	ATP:ADP adenylyltransferase activity
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004824	molecular_function	lysine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006430	biological_process	lysyl-tRNA aminoacylation
A	0015966	biological_process	diadenosine tetraphosphate biosynthetic process
A	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
A	0043032	biological_process	positive regulation of macrophage activation
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0003877	molecular_function	ATP:ADP adenylyltransferase activity
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004824	molecular_function	lysine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006430	biological_process	lysyl-tRNA aminoacylation
B	0015966	biological_process	diadenosine tetraphosphate biosynthetic process
B	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
B	0043032	biological_process	positive regulation of macrophage activation
B	0046872	molecular_function	metal ion binding
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003676	molecular_function	nucleic acid binding
C	0003877	molecular_function	ATP:ADP adenylyltransferase activity
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004824	molecular_function	lysine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006430	biological_process	lysyl-tRNA aminoacylation
C	0015966	biological_process	diadenosine tetraphosphate biosynthetic process
C	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
C	0043032	biological_process	positive regulation of macrophage activation
C	0046872	molecular_function	metal ion binding
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003676	molecular_function	nucleic acid binding
D	0003877	molecular_function	ATP:ADP adenylyltransferase activity
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004824	molecular_function	lysine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006430	biological_process	lysyl-tRNA aminoacylation
D	0015966	biological_process	diadenosine tetraphosphate biosynthetic process
D	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
D	0043032	biological_process	positive regulation of macrophage activation
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue LYS A 601

Chain	Residue
A	GLY212
A	KRS602
A	HOH707
A	ALA213
A	GLU236
A	ARG258
A	GLU274
A	TYR276
A	TYR424
A	GLU426
A	GLY471

---

site_id	AC2
Number of Residues	10
Details	binding site for residue KRS A 602

Chain	Residue
A	ARG258
A	THR265
A	HIS266
A	SER267
A	PHE270
A	GLU419
A	GLY473
A	GLY475
A	ARG478
A	LYS601

---

site_id	AC3
Number of Residues	15
Details	binding site for residue LYS B 601

Chain	Residue
B	GLY212
B	ALA213
B	ALA234
B	GLU236
B	ARG258
B	GLU274
B	TYR276
B	TYR424
B	GLU426
B	GLY471
B	THR472
B	GLY473
B	KRS602
B	HOH716
B	HOH720

---

site_id	AC4
Number of Residues	11
Details	binding site for residue KRS B 602

Chain	Residue
B	ARG258
B	HIS266
B	SER267
B	PHE270
B	GLU419
B	LEU420
B	ALA421
B	GLY473
B	GLY475
B	ARG478
B	LYS601

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO B 603

Chain	Residue
B	ASP283
B	SER322
B	PHE386
B	LYS388

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO B 604

Chain	Residue
B	ARG399
B	ARG402
B	HOH786
D	GLN31

---

site_id	AC7
Number of Residues	14
Details	binding site for residue LYS C 601

Chain	Residue
C	GLY212
C	ALA213
C	GLU236
C	ARG258
C	GLU274
C	TYR276
C	TYR424
C	GLU426
C	GLY471
C	THR472
C	GLY473
C	KRS602
C	HOH706
C	HOH711

---

site_id	AC8
Number of Residues	12
Details	binding site for residue KRS C 602

Chain	Residue
C	ARG258
C	THR265
C	HIS266
C	SER267
C	PHE270
C	MET272
C	LEU420
C	THR422
C	GLY473
C	GLY475
C	ARG478
C	LYS601

---

site_id	AC9
Number of Residues	15
Details	binding site for residue LYS D 601

Chain	Residue
D	GLY212
D	ALA213
D	ALA234
D	GLU236
D	ARG258
D	GLU274
D	TYR276
D	TYR424
D	GLU426
D	GLY471
D	THR472
D	KRS602
D	HOH716
D	HOH733
D	HOH734

---

site_id	AD1
Number of Residues	10
Details	binding site for residue KRS D 602

Chain	Residue
D	PHE270
D	LEU420
D	THR422
D	GLY473
D	GLY475
D	ARG478
D	LYS601
D	ARG258
D	HIS266
D	SER267

---