6AQH
Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY212 |
| A | KRS602 |
| A | HOH707 |
| A | ALA213 |
| A | GLU236 |
| A | ARG258 |
| A | GLU274 |
| A | TYR276 |
| A | TYR424 |
| A | GLU426 |
| A | GLY471 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue KRS A 602 |
| Chain | Residue |
| A | ARG258 |
| A | THR265 |
| A | HIS266 |
| A | SER267 |
| A | PHE270 |
| A | GLU419 |
| A | GLY473 |
| A | GLY475 |
| A | ARG478 |
| A | LYS601 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | GLY212 |
| B | ALA213 |
| B | ALA234 |
| B | GLU236 |
| B | ARG258 |
| B | GLU274 |
| B | TYR276 |
| B | TYR424 |
| B | GLU426 |
| B | GLY471 |
| B | THR472 |
| B | GLY473 |
| B | KRS602 |
| B | HOH716 |
| B | HOH720 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue KRS B 602 |
| Chain | Residue |
| B | ARG258 |
| B | HIS266 |
| B | SER267 |
| B | PHE270 |
| B | GLU419 |
| B | LEU420 |
| B | ALA421 |
| B | GLY473 |
| B | GLY475 |
| B | ARG478 |
| B | LYS601 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | ASP283 |
| B | SER322 |
| B | PHE386 |
| B | LYS388 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 604 |
| Chain | Residue |
| B | ARG399 |
| B | ARG402 |
| B | HOH786 |
| D | GLN31 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue LYS C 601 |
| Chain | Residue |
| C | GLY212 |
| C | ALA213 |
| C | GLU236 |
| C | ARG258 |
| C | GLU274 |
| C | TYR276 |
| C | TYR424 |
| C | GLU426 |
| C | GLY471 |
| C | THR472 |
| C | GLY473 |
| C | KRS602 |
| C | HOH706 |
| C | HOH711 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue KRS C 602 |
| Chain | Residue |
| C | ARG258 |
| C | THR265 |
| C | HIS266 |
| C | SER267 |
| C | PHE270 |
| C | MET272 |
| C | LEU420 |
| C | THR422 |
| C | GLY473 |
| C | GLY475 |
| C | ARG478 |
| C | LYS601 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue LYS D 601 |
| Chain | Residue |
| D | GLY212 |
| D | ALA213 |
| D | ALA234 |
| D | GLU236 |
| D | ARG258 |
| D | GLU274 |
| D | TYR276 |
| D | TYR424 |
| D | GLU426 |
| D | GLY471 |
| D | THR472 |
| D | KRS602 |
| D | HOH716 |
| D | HOH733 |
| D | HOH734 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue KRS D 602 |
| Chain | Residue |
| D | PHE270 |
| D | LEU420 |
| D | THR422 |
| D | GLY473 |
| D | GLY475 |
| D | ARG478 |
| D | LYS601 |
| D | ARG258 |
| D | HIS266 |
| D | SER267 |
