6AQG
Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0016874 | molecular_function | ligase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0016874 | molecular_function | ligase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY209 |
| A | HOH706 |
| A | HOH752 |
| A | HOH892 |
| A | ALA210 |
| A | GLU233 |
| A | ARG255 |
| A | GLU271 |
| A | TYR273 |
| A | TYR420 |
| A | GLU422 |
| A | GLY467 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue KRS A 602 |
| Chain | Residue |
| A | THR262 |
| A | HIS263 |
| A | SER264 |
| A | PHE267 |
| A | MET269 |
| A | LEU416 |
| A | GLY469 |
| A | GLY471 |
| A | ARG474 |
| A | ILE484 |
| A | HOH739 |
| A | HOH763 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MPD A 603 |
| Chain | Residue |
| A | GLY242 |
| A | GLY243 |
| A | PHE244 |
| D | GLY83 |
| D | ASP84 |
| D | ARG173 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 604 |
| Chain | Residue |
| A | GLU257 |
| A | GLY258 |
| A | ASP260 |
| A | HIS263 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MPD A 605 |
| Chain | Residue |
| A | VAL67 |
| A | PHE68 |
| A | PRO147 |
| A | VAL148 |
| A | VAL168 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | GLY209 |
| B | GLU233 |
| B | ARG255 |
| B | GLU271 |
| B | TYR273 |
| B | TYR420 |
| B | GLU422 |
| B | GLY467 |
| B | KRS602 |
| B | HOH710 |
| B | HOH803 |
| B | HOH868 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue KRS B 602 |
| Chain | Residue |
| B | ARG255 |
| B | THR262 |
| B | HIS263 |
| B | SER264 |
| B | PHE267 |
| B | LEU416 |
| B | GLY469 |
| B | GLY471 |
| B | ARG474 |
| B | ILE484 |
| B | LYS601 |
| B | HOH777 |
| B | HOH795 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MPD B 603 |
| Chain | Residue |
| B | GLY83 |
| B | ASP84 |
| C | GLY242 |
| C | GLY243 |
| C | PHE244 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue MPD B 604 |
| Chain | Residue |
| B | GLU257 |
| B | GLY258 |
| B | HIS263 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MPD B 605 |
| Chain | Residue |
| A | GLY331 |
| A | GLU332 |
| B | GLU332 |
| B | GLN333 |
| B | HOH769 |
| B | HOH863 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue MPD B 606 |
| Chain | Residue |
| B | HOH722 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue LYS C 601 |
| Chain | Residue |
| C | GLY209 |
| C | ALA210 |
| C | GLU233 |
| C | ARG255 |
| C | GLU271 |
| C | TYR273 |
| C | TYR420 |
| C | GLU422 |
| C | GLY467 |
| C | KRS602 |
| C | HOH716 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue KRS C 602 |
| Chain | Residue |
| C | GLY471 |
| C | ARG474 |
| C | LYS601 |
| C | HOH723 |
| C | GLU257 |
| C | THR262 |
| C | HIS263 |
| C | SER264 |
| C | PHE267 |
| C | MET269 |
| C | GLU415 |
| C | THR418 |
| C | GLY469 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MPD C 603 |
| Chain | Residue |
| B | LEU196 |
| B | GLY242 |
| B | GLY243 |
| B | PHE244 |
| C | GLY83 |
| C | ASP84 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MPD D 501 |
| Chain | Residue |
| A | GLY83 |
| A | ASP84 |
| A | ARG177 |
| D | GLY242 |
| D | GLY243 |
| D | PHE244 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue LYS D 502 |
| Chain | Residue |
| D | GLY209 |
| D | GLU233 |
| D | ARG255 |
| D | MET269 |
| D | GLU271 |
| D | TYR273 |
| D | TYR420 |
| D | GLU422 |
| D | GLY467 |
| D | KRS503 |
| D | HOH649 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for residue KRS D 503 |
| Chain | Residue |
| D | GLU257 |
| D | THR262 |
| D | HIS263 |
| D | SER264 |
| D | PHE267 |
| D | MET269 |
| D | GLU415 |
| D | THR418 |
| D | GLY469 |
| D | ARG474 |
| D | LYS502 |
| D | HOH702 |
