6APE
Crystal Structure of Bifunctional protein FolD from Helicobacter pylori
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | LYS87 |
| A | ASP248 |
| A | HOH433 |
| A | HOH686 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | ILE160 |
| A | LYS161 |
| A | HOH460 |
| A | HOH673 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | GLY212 |
| A | VAL213 |
| A | GLY214 |
| A | GLY234 |
| A | ILE235 |
| A | HOH595 |
| A | ILE174 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | ARG106 |
| A | HIS155 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | LYS57 |
| A | ASP124 |
| A | THR270 |
| A | LEU274 |
| A | HOH421 |
| A | HOH426 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EaELLslIkdYNtDqnisgVLVQLPL |
| Chain | Residue | Details |
| A | GLU79-LEU104 |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PKGVGPMTI |
| Chain | Residue | Details |
| A | PRO263-ILE271 |
