6AJG

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SQ109

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 3RX A 1001

Chain	Residue
A	ILE249
A	ASP645
A	ILE253
A	ASP256
A	TYR257
A	ILE297
A	SER301
A	ALA637
A	VAL638
A	LEU642

---

site_id	AC2
Number of Residues	11
Details	binding site for residue LMT A 1002

Chain	Residue
A	THR66
A	SER67
A	VAL109
A	ASP119
A	THR121
A	SER136
A	LEU171
A	LEU174
A	GLN442
A	ARG453
A	LMT1003

---

site_id	AC3
Number of Residues	14
Details	binding site for residue LMT A 1003

Chain	Residue
A	GLN40
A	ASP64
A	SER67
A	ILE182
A	HIS239
A	PHE240
A	PHE241
A	ILE427
A	ARG453
A	THR454
A	GLU455
A	THR549
A	LEU698
A	LMT1002

---

site_id	AC4
Number of Residues	7
Details	binding site for residue LMT A 1004

Chain	Residue
A	LEU422
A	SER423
A	LEU424
A	GLN554
A	ILE557
A	LEU564
A	LEU600

---

site_id	AC5
Number of Residues	7
Details	binding site for residue LMT A 1005

Chain	Residue
A	LEU23
A	GLY27
A	TYR30
A	ASP77
A	LYS79
A	GLU234
A	PHE235

---

site_id	AC6
Number of Residues	10
Details	binding site for residue LMT A 1006

Chain	Residue
A	LEU25
A	ILE32
A	GLY35
A	THR179
A	GLY180
A	ILE182
A	GLY183
A	LEU226
A	PHE240
A	GLN243

---

site_id	AC7
Number of Residues	9
Details	binding site for residue LMT A 1007

Chain	Residue
A	GLN-3
A	THR285
A	ARG288
A	THR289
A	PHE292
A	LEU581
A	ALA582
A	SER652
A	ARG653

---

site_id	AC8
Number of Residues	7
Details	binding site for residue LMT A 1008

Chain	Residue
A	TRP390
A	THR672
A	ALA673
A	GLY676
A	THR680
A	ARG720
A	MET721

---

site_id	AC9
Number of Residues	4
Details	binding site for residue LMT A 1009

Chain	Residue
A	THR236
A	LYS313
A	TYR317
A	LMT1010

---

site_id	AD1
Number of Residues	2
Details	binding site for residue LMT A 1010

Chain	Residue
A	TYR317
A	LMT1009

---

site_id	AD2
Number of Residues	8
Details	binding site for residue MHA A 1011

Chain	Residue
A	ASP759
A	THR891
A	PRO892
A	ASN893
A	ARG894
A	ILE917
A	LYS918
A	ALA919

---

site_id	AD3
Number of Residues	7
Details	binding site for residue MHA A 1012

Chain	Residue
A	GLY618
A	GLY862
A	PHE863
A	THR864
A	ASN865
A	SER866
A	ASN881

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	69
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	330
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	19
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OR2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AJG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Part of the proton transportation network","evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32512002","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---