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6AJ5

Crystal structure of ligand-free type DHODH from Eimeria tenella

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004152molecular_functiondihydroorotate dehydrogenase activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0009220biological_processpyrimidine ribonucleotide biosynthetic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
A0044205biological_process'de novo' UMP biosynthetic process
A0106430molecular_functiondihydroorotate dehydrogenase (quinone) activity
B0000166molecular_functionnucleotide binding
B0004152molecular_functiondihydroorotate dehydrogenase activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0009220biological_processpyrimidine ribonucleotide biosynthetic process
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
B0044205biological_process'de novo' UMP biosynthetic process
B0106430molecular_functiondihydroorotate dehydrogenase (quinone) activity
C0000166molecular_functionnucleotide binding
C0004152molecular_functiondihydroorotate dehydrogenase activity
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
C0009220biological_processpyrimidine ribonucleotide biosynthetic process
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
C0044205biological_process'de novo' UMP biosynthetic process
C0106430molecular_functiondihydroorotate dehydrogenase (quinone) activity
D0000166molecular_functionnucleotide binding
D0004152molecular_functiondihydroorotate dehydrogenase activity
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
D0009220biological_processpyrimidine ribonucleotide biosynthetic process
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016627molecular_functionoxidoreductase activity, acting on the CH-CH group of donors
D0044205biological_process'de novo' UMP biosynthetic process
D0106430molecular_functiondihydroorotate dehydrogenase (quinone) activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue FMN A 501
ChainResidue
AALA62
ALYS261
ATHR289
AASN290
ASER311
AGLY312
ASER339
AGLY340
AGLY341
ATYR362
ATHR363
AALA63
AORO502
AGLY64
ALYS67
ATHR87
AILE101
AASN112
AASN149
AASN180

site_idAC2
Number of Residues11
Detailsbinding site for residue ORO A 502
ChainResidue
AASN112
AARG113
ACYS114
AGLY115
APHE116
AASN180
ASER183
AASN185
AASN290
ATHR291
AFMN501

site_idAC3
Number of Residues22
Detailsbinding site for residue FMN B 501
ChainResidue
BALA62
BALA63
BGLY64
BLYS67
BTHR87
BILE101
BASN112
BASN149
BASN180
BLYS261
BTHR289
BASN290
BSER311
BGLY312
BLEU315
BSER339
BGLY340
BGLY341
BVAL361
BTYR362
BTHR363
BORO502

site_idAC4
Number of Residues10
Detailsbinding site for residue ORO B 502
ChainResidue
BASN112
BCYS114
BGLY115
BPHE116
BASN180
BSER183
BASN185
BASN290
BTHR291
BFMN501

site_idAC5
Number of Residues20
Detailsbinding site for residue FMN C 501
ChainResidue
CALA63
CGLY64
CLYS67
CTHR87
CILE101
CASN112
CASN149
CASN180
CLYS261
CTHR289
CASN290
CSER311
CGLY312
CLEU315
CSER339
CGLY340
CGLY341
CTYR362
CTHR363
CORO502

site_idAC6
Number of Residues11
Detailsbinding site for residue ORO C 502
ChainResidue
CLYS67
CASN112
CCYS114
CGLY115
CPHE116
CASN180
CSER183
CPRO184
CASN290
CTHR291
CFMN501

site_idAC7
Number of Residues20
Detailsbinding site for residue FMN D 501
ChainResidue
DASN112
DASN149
DASN180
DLYS261
DTHR289
DASN290
DSER311
DGLY312
DSER339
DGLY340
DGLY341
DTYR362
DTHR363
DSER364
DORO502
DALA63
DGLY64
DLYS67
DTHR87
DILE101

site_idAC8
Number of Residues10
Detailsbinding site for residue ORO D 502
ChainResidue
DASN112
DCYS114
DGLY115
DPHE116
DASN180
DSER183
DASN185
DASN290
DTHR291
DFMN501

Functional Information from PROSITE/UniProt
site_idPS00911
Number of Residues20
DetailsDHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfvevGTITpkpQlGNpkPR
ChainResidueDetails
AGLY81-ARG100

site_idPS00912
Number of Residues21
DetailsDHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIAsGGIeTgldAykRIrAGA
ChainResidueDetails
AILE336-ALA356

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PDB entries from 2025-06-18

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