Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AJ5

Crystal structure of ligand-free type DHODH from Eimeria tenella

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0005743	cellular_component	mitochondrial inner membrane
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity
B	0000166	molecular_function	nucleotide binding
B	0004152	molecular_function	dihydroorotate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0005743	cellular_component	mitochondrial inner membrane
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity
C	0000166	molecular_function	nucleotide binding
C	0004152	molecular_function	dihydroorotate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0005743	cellular_component	mitochondrial inner membrane
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity
D	0000166	molecular_function	nucleotide binding
D	0004152	molecular_function	dihydroorotate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0005743	cellular_component	mitochondrial inner membrane
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue FMN A 501

Chain	Residue
A	ALA62
A	LYS261
A	THR289
A	ASN290
A	SER311
A	GLY312
A	SER339
A	GLY340
A	GLY341
A	TYR362
A	THR363
A	ALA63
A	ORO502
A	GLY64
A	LYS67
A	THR87
A	ILE101
A	ASN112
A	ASN149
A	ASN180

site_id	AC2
Number of Residues	11
Details	binding site for residue ORO A 502

Chain	Residue
A	ASN112
A	ARG113
A	CYS114
A	GLY115
A	PHE116
A	ASN180
A	SER183
A	ASN185
A	ASN290
A	THR291
A	FMN501

site_id	AC3
Number of Residues	22
Details	binding site for residue FMN B 501

Chain	Residue
B	ALA62
B	ALA63
B	GLY64
B	LYS67
B	THR87
B	ILE101
B	ASN112
B	ASN149
B	ASN180
B	LYS261
B	THR289
B	ASN290
B	SER311
B	GLY312
B	LEU315
B	SER339
B	GLY340
B	GLY341
B	VAL361
B	TYR362
B	THR363
B	ORO502

site_id	AC4
Number of Residues	10
Details	binding site for residue ORO B 502

Chain	Residue
B	ASN112
B	CYS114
B	GLY115
B	PHE116
B	ASN180
B	SER183
B	ASN185
B	ASN290
B	THR291
B	FMN501

site_id	AC5
Number of Residues	20
Details	binding site for residue FMN C 501

Chain	Residue
C	ALA63
C	GLY64
C	LYS67
C	THR87
C	ILE101
C	ASN112
C	ASN149
C	ASN180
C	LYS261
C	THR289
C	ASN290
C	SER311
C	GLY312
C	LEU315
C	SER339
C	GLY340
C	GLY341
C	TYR362
C	THR363
C	ORO502

site_id	AC6
Number of Residues	11
Details	binding site for residue ORO C 502

Chain	Residue
C	LYS67
C	ASN112
C	CYS114
C	GLY115
C	PHE116
C	ASN180
C	SER183
C	PRO184
C	ASN290
C	THR291
C	FMN501

site_id	AC7
Number of Residues	20
Details	binding site for residue FMN D 501

Chain	Residue
D	ASN112
D	ASN149
D	ASN180
D	LYS261
D	THR289
D	ASN290
D	SER311
D	GLY312
D	SER339
D	GLY340
D	GLY341
D	TYR362
D	THR363
D	SER364
D	ORO502
D	ALA63
D	GLY64
D	LYS67
D	THR87
D	ILE101

site_id	AC8
Number of Residues	10
Details	binding site for residue ORO D 502

Chain	Residue
D	ASN112
D	CYS114
D	GLY115
D	PHE116
D	ASN180
D	SER183
D	ASN185
D	ASN290
D	THR291
D	FMN501

Functional Information from PROSITE/UniProt

site_id	PS00911
Number of Residues	20
Details	DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfvevGTITpkpQlGNpkPR

Chain	Residue	Details
A	GLY81-ARG100

site_id	PS00912
Number of Residues	21
Details	DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIAsGGIeTgldAykRIrAGA

Chain	Residue	Details
A	ILE336-ALA356

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)