6AG9

Crystal structure of uPA in complex with 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2- carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004252	molecular_function	serine-type endopeptidase activity
U	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 9XF U 301

Chain	Residue
U	ASP189
U	SO4302
U	HOH450
U	HOH467
U	SER190
U	GLN192
U	SER195
U	SER214
U	GLY216
U	GLY219
U	CYS220
U	GLY226

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 U 302

Chain	Residue
U	HIS57
U	GLY193
U	SER195
U	9XF301
U	HOH415
U	HOH457

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
U	ILE53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
U	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
U	HIS57
U	ASP102
U	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681

Chain	Residue	Details
U	SER146

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
U	GLN145

---