6AG5

Crystal structure of Ard1 N-terminal acetyltransferase E88H/H127E mutant from Sulfolobus solfataricus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006474	biological_process	N-terminal protein amino acid acetylation
A	0008080	molecular_function	N-acetyltransferase activity
A	0008999	molecular_function	protein-N-terminal-alanine acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0031415	cellular_component	NatA complex
A	0046872	molecular_function	metal ion binding
A	0120518	molecular_function	protein N-terminal-methionine acetyltransferase activity
A	1990189	molecular_function	protein N-terminal-serine acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue ACO A 201

Chain	Residue
A	PHE74
A	ALA104
A	THR105
A	HIS127
A	ASN132
A	PRO134
A	LEU138
A	TYR139
A	LYS141
A	CA202
A	HOH325
A	ILE92
A	HOH328
A	HOH329
A	HOH349
A	ALA93
A	VAL94
A	ARG99
A	ARG100
A	LYS101
A	GLY102
A	ILE103

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CA A 202

Chain	Residue
A	VAL128
A	ARG129
A	ASN132
A	ACO201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	155
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26593285","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C88","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20419351","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23959863","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X7B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R3L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Plays an important role in substrate specificity","evidences":[{"source":"PubMed","id":"25728374","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Plays an important role in modulating multiple conformations of loop regions and contributes to protein thermostability","evidences":[{"source":"PubMed","id":"26593285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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