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6AE3

Crystal structure of GSK3beta complexed with Morin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000320biological_processre-entry into mitotic cell cycle
A0001558biological_processregulation of cell growth
A0001837biological_processepithelial to mesenchymal transition
A0002039molecular_functionp53 binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0006366biological_processtranscription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0006983biological_processER overload response
A0007010biological_processcytoskeleton organization
A0007127biological_processmeiosis I
A0007163biological_processestablishment or maintenance of cell polarity
A0007399biological_processnervous system development
A0007409biological_processaxonogenesis
A0007520biological_processmyoblast fusion
A0007623biological_processcircadian rhythm
A0008013molecular_functionbeta-catenin binding
A0008286biological_processinsulin receptor signaling pathway
A0009887biological_processanimal organ morphogenesis
A0009968biological_processnegative regulation of signal transduction
A0010043biological_processresponse to zinc ion
A0010508biological_processpositive regulation of autophagy
A0010614biological_processnegative regulation of cardiac muscle hypertrophy
A0010628biological_processpositive regulation of gene expression
A0010719biological_processnegative regulation of epithelial to mesenchymal transition
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010918biological_processpositive regulation of mitochondrial membrane potential
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0014043biological_processnegative regulation of neuron maturation
A0014069cellular_componentpostsynaptic density
A0014902biological_processmyotube differentiation
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016477biological_processcell migration
A0018105biological_processpeptidyl-serine phosphorylation
A0019901molecular_functionprotein kinase binding
A0030010biological_processestablishment of cell polarity
A0030011biological_processmaintenance of cell polarity
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030516biological_processregulation of axon extension
A0030877cellular_componentbeta-catenin destruction complex
A0031175biological_processneuron projection development
A0032007biological_processnegative regulation of TOR signaling
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032886biological_processregulation of microtubule-based process
A0032991cellular_componentprotein-containing complex
A0033690biological_processpositive regulation of osteoblast proliferation
A0034392biological_processnegative regulation of smooth muscle cell apoptotic process
A0035255molecular_functionionotropic glutamate receptor binding
A0035372biological_processprotein localization to microtubule
A0035556biological_processintracellular signal transduction
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0035733biological_processhepatic stellate cell activation
A0036016biological_processcellular response to interleukin-3
A0042752biological_processregulation of circadian rhythm
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043227cellular_componentmembrane-bounded organelle
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043525biological_processpositive regulation of neuron apoptotic process
A0045444biological_processfat cell differentiation
A0045667biological_processregulation of osteoblast differentiation
A0045672biological_processpositive regulation of osteoclast differentiation
A0045719biological_processnegative regulation of glycogen biosynthetic process
A0045724biological_processpositive regulation of cilium assembly
A0045732biological_processpositive regulation of protein catabolic process
A0045773biological_processpositive regulation of axon extension
A0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
A0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046825biological_processregulation of protein export from nucleus
A0046827biological_processpositive regulation of protein export from nucleus
A0046849biological_processbone remodeling
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048511biological_processrhythmic process
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048675biological_processaxon extension
A0048814biological_processregulation of dendrite morphogenesis
A0048863biological_processstem cell differentiation
A0050321molecular_functiontau-protein kinase activity
A0050770biological_processregulation of axonogenesis
A0050774biological_processnegative regulation of dendrite morphogenesis
A0051093biological_processnegative regulation of developmental process
A0051128biological_processregulation of cellular component organization
A0060070biological_processcanonical Wnt signaling pathway
A0061049biological_processcell growth involved in cardiac muscle cell development
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070840molecular_functiondynein complex binding
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071260biological_processcellular response to mechanical stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0072687cellular_componentmeiotic spindle
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090290biological_processpositive regulation of osteoclast proliferation
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097284biological_processhepatocyte apoptotic process
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0106027biological_processneuron projection organization
A0106310molecular_functionprotein serine kinase activity
A0120283molecular_functionprotein serine/threonine kinase binding
A0141068biological_processautosome genomic imprinting
A1900181biological_processnegative regulation of protein localization to nucleus
A1900271biological_processregulation of long-term synaptic potentiation
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1901984biological_processnegative regulation of protein acetylation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903566biological_processpositive regulation of protein localization to cilium
A1904339biological_processnegative regulation of dopaminergic neuron differentiation
A1904646biological_processcellular response to amyloid-beta
A1904780biological_processnegative regulation of protein localization to centrosome
A1990904cellular_componentribonucleoprotein complex
A1990909cellular_componentWnt signalosome
A2000171biological_processnegative regulation of dendrite development
A2000463biological_processpositive regulation of excitatory postsynaptic potential
A2000573biological_processpositive regulation of DNA biosynthetic process
A2000727biological_processpositive regulation of cardiac muscle cell differentiation
A2000738biological_processpositive regulation of stem cell differentiation
A2001223biological_processnegative regulation of neuron migration
B0000320biological_processre-entry into mitotic cell cycle
B0001558biological_processregulation of cell growth
B0001837biological_processepithelial to mesenchymal transition
B0002039molecular_functionp53 binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0005977biological_processglycogen metabolic process
B0006366biological_processtranscription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0006983biological_processER overload response
B0007010biological_processcytoskeleton organization
B0007127biological_processmeiosis I
B0007163biological_processestablishment or maintenance of cell polarity
B0007399biological_processnervous system development
B0007409biological_processaxonogenesis
B0007520biological_processmyoblast fusion
B0007623biological_processcircadian rhythm
B0008013molecular_functionbeta-catenin binding
B0008286biological_processinsulin receptor signaling pathway
B0009887biological_processanimal organ morphogenesis
B0009968biological_processnegative regulation of signal transduction
B0010043biological_processresponse to zinc ion
B0010508biological_processpositive regulation of autophagy
B0010614biological_processnegative regulation of cardiac muscle hypertrophy
B0010628biological_processpositive regulation of gene expression
B0010719biological_processnegative regulation of epithelial to mesenchymal transition
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010918biological_processpositive regulation of mitochondrial membrane potential
B0010975biological_processregulation of neuron projection development
B0010977biological_processnegative regulation of neuron projection development
B0014043biological_processnegative regulation of neuron maturation
B0014069cellular_componentpostsynaptic density
B0014902biological_processmyotube differentiation
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016477biological_processcell migration
B0018105biological_processpeptidyl-serine phosphorylation
B0019901molecular_functionprotein kinase binding
B0030010biological_processestablishment of cell polarity
B0030011biological_processmaintenance of cell polarity
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030516biological_processregulation of axon extension
B0030877cellular_componentbeta-catenin destruction complex
B0031175biological_processneuron projection development
B0032007biological_processnegative regulation of TOR signaling
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032886biological_processregulation of microtubule-based process
B0032991cellular_componentprotein-containing complex
B0033690biological_processpositive regulation of osteoblast proliferation
B0034392biological_processnegative regulation of smooth muscle cell apoptotic process
B0035255molecular_functionionotropic glutamate receptor binding
B0035372biological_processprotein localization to microtubule
B0035556biological_processintracellular signal transduction
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0035733biological_processhepatic stellate cell activation
B0036016biological_processcellular response to interleukin-3
B0042752biological_processregulation of circadian rhythm
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0043227cellular_componentmembrane-bounded organelle
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0043525biological_processpositive regulation of neuron apoptotic process
B0045444biological_processfat cell differentiation
B0045667biological_processregulation of osteoblast differentiation
B0045672biological_processpositive regulation of osteoclast differentiation
B0045719biological_processnegative regulation of glycogen biosynthetic process
B0045724biological_processpositive regulation of cilium assembly
B0045732biological_processpositive regulation of protein catabolic process
B0045773biological_processpositive regulation of axon extension
B0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
B0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046825biological_processregulation of protein export from nucleus
B0046827biological_processpositive regulation of protein export from nucleus
B0046849biological_processbone remodeling
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048511biological_processrhythmic process
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0048675biological_processaxon extension
B0048814biological_processregulation of dendrite morphogenesis
B0048863biological_processstem cell differentiation
B0050321molecular_functiontau-protein kinase activity
B0050770biological_processregulation of axonogenesis
B0050774biological_processnegative regulation of dendrite morphogenesis
B0051093biological_processnegative regulation of developmental process
B0051128biological_processregulation of cellular component organization
B0060070biological_processcanonical Wnt signaling pathway
B0061049biological_processcell growth involved in cardiac muscle cell development
B0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070840molecular_functiondynein complex binding
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071260biological_processcellular response to mechanical stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0072687cellular_componentmeiotic spindle
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090290biological_processpositive regulation of osteoclast proliferation
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0097284biological_processhepatocyte apoptotic process
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0106027biological_processneuron projection organization
B0106310molecular_functionprotein serine kinase activity
B0120283molecular_functionprotein serine/threonine kinase binding
B0141068biological_processautosome genomic imprinting
B1900181biological_processnegative regulation of protein localization to nucleus
B1900271biological_processregulation of long-term synaptic potentiation
B1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
B1901984biological_processnegative regulation of protein acetylation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903566biological_processpositive regulation of protein localization to cilium
B1904339biological_processnegative regulation of dopaminergic neuron differentiation
B1904646biological_processcellular response to amyloid-beta
B1904780biological_processnegative regulation of protein localization to centrosome
B1990904cellular_componentribonucleoprotein complex
B1990909cellular_componentWnt signalosome
B2000171biological_processnegative regulation of dendrite development
B2000463biological_processpositive regulation of excitatory postsynaptic potential
B2000573biological_processpositive regulation of DNA biosynthetic process
B2000727biological_processpositive regulation of cardiac muscle cell differentiation
B2000738biological_processpositive regulation of stem cell differentiation
B2001223biological_processnegative regulation of neuron migration
C0000320biological_processre-entry into mitotic cell cycle
C0001558biological_processregulation of cell growth
C0001837biological_processepithelial to mesenchymal transition
C0002039molecular_functionp53 binding
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0005977biological_processglycogen metabolic process
C0006366biological_processtranscription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006611biological_processprotein export from nucleus
C0006983biological_processER overload response
C0007010biological_processcytoskeleton organization
C0007127biological_processmeiosis I
C0007163biological_processestablishment or maintenance of cell polarity
C0007399biological_processnervous system development
C0007409biological_processaxonogenesis
C0007520biological_processmyoblast fusion
C0007623biological_processcircadian rhythm
C0008013molecular_functionbeta-catenin binding
C0008286biological_processinsulin receptor signaling pathway
C0009887biological_processanimal organ morphogenesis
C0009968biological_processnegative regulation of signal transduction
C0010043biological_processresponse to zinc ion
C0010508biological_processpositive regulation of autophagy
C0010614biological_processnegative regulation of cardiac muscle hypertrophy
C0010628biological_processpositive regulation of gene expression
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0010918biological_processpositive regulation of mitochondrial membrane potential
C0010975biological_processregulation of neuron projection development
C0010977biological_processnegative regulation of neuron projection development
C0014043biological_processnegative regulation of neuron maturation
C0014069cellular_componentpostsynaptic density
C0014902biological_processmyotube differentiation
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0016477biological_processcell migration
C0018105biological_processpeptidyl-serine phosphorylation
C0019901molecular_functionprotein kinase binding
C0030010biological_processestablishment of cell polarity
C0030011biological_processmaintenance of cell polarity
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0030516biological_processregulation of axon extension
C0030877cellular_componentbeta-catenin destruction complex
C0031175biological_processneuron projection development
C0032007biological_processnegative regulation of TOR signaling
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032886biological_processregulation of microtubule-based process
C0032991cellular_componentprotein-containing complex
C0033690biological_processpositive regulation of osteoblast proliferation
C0034392biological_processnegative regulation of smooth muscle cell apoptotic process
C0035255molecular_functionionotropic glutamate receptor binding
C0035372biological_processprotein localization to microtubule
C0035556biological_processintracellular signal transduction
C0035729biological_processcellular response to hepatocyte growth factor stimulus
C0035733biological_processhepatic stellate cell activation
C0036016biological_processcellular response to interleukin-3
C0042752biological_processregulation of circadian rhythm
C0042981biological_processregulation of apoptotic process
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0043227cellular_componentmembrane-bounded organelle
C0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
C0043525biological_processpositive regulation of neuron apoptotic process
C0045444biological_processfat cell differentiation
C0045667biological_processregulation of osteoblast differentiation
C0045672biological_processpositive regulation of osteoclast differentiation
C0045719biological_processnegative regulation of glycogen biosynthetic process
C0045724biological_processpositive regulation of cilium assembly
C0045732biological_processpositive regulation of protein catabolic process
C0045773biological_processpositive regulation of axon extension
C0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
C0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046627biological_processnegative regulation of insulin receptor signaling pathway
C0046825biological_processregulation of protein export from nucleus
C0046827biological_processpositive regulation of protein export from nucleus
C0046849biological_processbone remodeling
C0048156molecular_functiontau protein binding
C0048168biological_processregulation of neuronal synaptic plasticity
C0048471cellular_componentperinuclear region of cytoplasm
C0048511biological_processrhythmic process
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0048675biological_processaxon extension
C0048814biological_processregulation of dendrite morphogenesis
C0048863biological_processstem cell differentiation
C0050321molecular_functiontau-protein kinase activity
C0050770biological_processregulation of axonogenesis
C0050774biological_processnegative regulation of dendrite morphogenesis
C0051093biological_processnegative regulation of developmental process
C0051128biological_processregulation of cellular component organization
C0060070biological_processcanonical Wnt signaling pathway
C0061049biological_processcell growth involved in cardiac muscle cell development
C0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070840molecular_functiondynein complex binding
C0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
C0071260biological_processcellular response to mechanical stimulus
C0071385biological_processcellular response to glucocorticoid stimulus
C0072687cellular_componentmeiotic spindle
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090290biological_processpositive regulation of osteoclast proliferation
C0097191biological_processextrinsic apoptotic signaling pathway
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0097284biological_processhepatocyte apoptotic process
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0106027biological_processneuron projection organization
C0106310molecular_functionprotein serine kinase activity
C0120283molecular_functionprotein serine/threonine kinase binding
C0141068biological_processautosome genomic imprinting
C1900181biological_processnegative regulation of protein localization to nucleus
C1900271biological_processregulation of long-term synaptic potentiation
C1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
C1901984biological_processnegative regulation of protein acetylation
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C1903566biological_processpositive regulation of protein localization to cilium
C1904339biological_processnegative regulation of dopaminergic neuron differentiation
C1904646biological_processcellular response to amyloid-beta
C1904780biological_processnegative regulation of protein localization to centrosome
C1990904cellular_componentribonucleoprotein complex
C1990909cellular_componentWnt signalosome
C2000171biological_processnegative regulation of dendrite development
C2000463biological_processpositive regulation of excitatory postsynaptic potential
C2000573biological_processpositive regulation of DNA biosynthetic process
C2000727biological_processpositive regulation of cardiac muscle cell differentiation
C2000738biological_processpositive regulation of stem cell differentiation
C2001223biological_processnegative regulation of neuron migration
D0000320biological_processre-entry into mitotic cell cycle
D0001558biological_processregulation of cell growth
D0001837biological_processepithelial to mesenchymal transition
D0002039molecular_functionp53 binding
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0005886cellular_componentplasma membrane
D0005977biological_processglycogen metabolic process
D0006366biological_processtranscription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006611biological_processprotein export from nucleus
D0006983biological_processER overload response
D0007010biological_processcytoskeleton organization
D0007127biological_processmeiosis I
D0007163biological_processestablishment or maintenance of cell polarity
D0007399biological_processnervous system development
D0007409biological_processaxonogenesis
D0007520biological_processmyoblast fusion
D0007623biological_processcircadian rhythm
D0008013molecular_functionbeta-catenin binding
D0008286biological_processinsulin receptor signaling pathway
D0009887biological_processanimal organ morphogenesis
D0009968biological_processnegative regulation of signal transduction
D0010043biological_processresponse to zinc ion
D0010508biological_processpositive regulation of autophagy
D0010614biological_processnegative regulation of cardiac muscle hypertrophy
D0010628biological_processpositive regulation of gene expression
D0010719biological_processnegative regulation of epithelial to mesenchymal transition
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010918biological_processpositive regulation of mitochondrial membrane potential
D0010975biological_processregulation of neuron projection development
D0010977biological_processnegative regulation of neuron projection development
D0014043biological_processnegative regulation of neuron maturation
D0014069cellular_componentpostsynaptic density
D0014902biological_processmyotube differentiation
D0016020cellular_componentmembrane
D0016055biological_processWnt signaling pathway
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0016477biological_processcell migration
D0018105biological_processpeptidyl-serine phosphorylation
D0019901molecular_functionprotein kinase binding
D0030010biological_processestablishment of cell polarity
D0030011biological_processmaintenance of cell polarity
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0030516biological_processregulation of axon extension
D0030877cellular_componentbeta-catenin destruction complex
D0031175biological_processneuron projection development
D0032007biological_processnegative regulation of TOR signaling
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032886biological_processregulation of microtubule-based process
D0032991cellular_componentprotein-containing complex
D0033690biological_processpositive regulation of osteoblast proliferation
D0034392biological_processnegative regulation of smooth muscle cell apoptotic process
D0035255molecular_functionionotropic glutamate receptor binding
D0035372biological_processprotein localization to microtubule
D0035556biological_processintracellular signal transduction
D0035729biological_processcellular response to hepatocyte growth factor stimulus
D0035733biological_processhepatic stellate cell activation
D0036016biological_processcellular response to interleukin-3
D0042752biological_processregulation of circadian rhythm
D0042981biological_processregulation of apoptotic process
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043197cellular_componentdendritic spine
D0043198cellular_componentdendritic shaft
D0043227cellular_componentmembrane-bounded organelle
D0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
D0043525biological_processpositive regulation of neuron apoptotic process
D0045444biological_processfat cell differentiation
D0045667biological_processregulation of osteoblast differentiation
D0045672biological_processpositive regulation of osteoclast differentiation
D0045719biological_processnegative regulation of glycogen biosynthetic process
D0045724biological_processpositive regulation of cilium assembly
D0045732biological_processpositive regulation of protein catabolic process
D0045773biological_processpositive regulation of axon extension
D0045886biological_processnegative regulation of synaptic assembly at neuromuscular junction
D0045887biological_processpositive regulation of synaptic assembly at neuromuscular junction
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046627biological_processnegative regulation of insulin receptor signaling pathway
D0046825biological_processregulation of protein export from nucleus
D0046827biological_processpositive regulation of protein export from nucleus
D0046849biological_processbone remodeling
D0048156molecular_functiontau protein binding
D0048168biological_processregulation of neuronal synaptic plasticity
D0048471cellular_componentperinuclear region of cytoplasm
D0048511biological_processrhythmic process
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0048675biological_processaxon extension
D0048814biological_processregulation of dendrite morphogenesis
D0048863biological_processstem cell differentiation
D0050321molecular_functiontau-protein kinase activity
D0050770biological_processregulation of axonogenesis
D0050774biological_processnegative regulation of dendrite morphogenesis
D0051093biological_processnegative regulation of developmental process
D0051128biological_processregulation of cellular component organization
D0060070biological_processcanonical Wnt signaling pathway
D0061049biological_processcell growth involved in cardiac muscle cell development
D0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
D0070507biological_processregulation of microtubule cytoskeleton organization
D0070840molecular_functiondynein complex binding
D0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
D0071260biological_processcellular response to mechanical stimulus
D0071385biological_processcellular response to glucocorticoid stimulus
D0072687cellular_componentmeiotic spindle
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090290biological_processpositive regulation of osteoclast proliferation
D0097191biological_processextrinsic apoptotic signaling pathway
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0097284biological_processhepatocyte apoptotic process
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0106027biological_processneuron projection organization
D0106310molecular_functionprotein serine kinase activity
D0120283molecular_functionprotein serine/threonine kinase binding
D0141068biological_processautosome genomic imprinting
D1900181biological_processnegative regulation of protein localization to nucleus
D1900271biological_processregulation of long-term synaptic potentiation
D1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
D1901984biological_processnegative regulation of protein acetylation
D1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
D1903566biological_processpositive regulation of protein localization to cilium
D1904339biological_processnegative regulation of dopaminergic neuron differentiation
D1904646biological_processcellular response to amyloid-beta
D1904780biological_processnegative regulation of protein localization to centrosome
D1990904cellular_componentribonucleoprotein complex
D1990909cellular_componentWnt signalosome
D2000171biological_processnegative regulation of dendrite development
D2000463biological_processpositive regulation of excitatory postsynaptic potential
D2000573biological_processpositive regulation of DNA biosynthetic process
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
D2000738biological_processpositive regulation of stem cell differentiation
D2001223biological_processnegative regulation of neuron migration
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue MRI A 501
ChainResidue
AGLY63
ALEU188
ACYS199
AASP200
AHOH705
BGLY262
AASN64
AVAL70
ALYS85
AVAL110
ALEU132
AASP133
ATYR134
AVAL135

site_idAC2
Number of Residues6
Detailsbinding site for residue GOL A 502
ChainResidue
AARG96
AARG180
ALYS205
AASN213
AVAL214
AHOH629

site_idAC3
Number of Residues18
Detailsbinding site for residue MRI B 501
ChainResidue
AGLY262
BGLY63
BASN64
BPHE67
BVAL70
BALA83
BLYS85
BVAL110
BLEU132
BASP133
BTYR134
BVAL135
BLEU188
BCYS199
BASP200
BHOH605
BHOH609
BHOH716

site_idAC4
Number of Residues6
Detailsbinding site for residue GOL B 502
ChainResidue
BARG96
BARG180
BLYS205
BASN213
BVAL214
BHOH606

site_idAC5
Number of Residues5
Detailsbinding site for residue GOL C 501
ChainResidue
CARG96
CARG180
CLYS205
CASN213
CVAL214

site_idAC6
Number of Residues5
Detailsbinding site for residue GOL D 501
ChainResidue
DARG96
DARG180
DLYS205
DASN213
DVAL214

site_idAC7
Number of Residues4
Detailsbinding site for Ligand ARG D 354 bound to ASN D 352
ChainResidue
DLYS349
DLEU350
DASN352
DASP355

site_idAC8
Number of Residues10
Detailsbinding site for Di-peptide LEU C 266 and ILE C 270
ChainResidue
CPHE229
CVAL263
CASP264
CGLN265
CVAL267
CGLU268
CILE269
CLYS271
CVAL272
CGLY274

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP181
BASP181
CASP181
DASP181

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62
ALYS85
BILE62
BLYS85
CILE62
CLYS85
DILE62
DLYS85

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3 => ECO:0000269|PubMed:22057101, ECO:0000269|PubMed:23395175, ECO:0000269|PubMed:24742671, ECO:0000269|PubMed:27827363
ChainResidueDetails
ASER9
BSER9
CSER9
DSER9

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P49841
ChainResidueDetails
APTR216
BPTR216
CPTR216
DPTR216

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:15345747
ChainResidueDetails
ASER389
BSER389
CSER389
DSER389

site_idSWS_FT_FI6
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P49841
ChainResidueDetails
ACYS14
BCYS14
CCYS14
DCYS14

223532

PDB entries from 2024-08-07

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