6ACO
histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2BK120
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS207 |
| A | CYS212 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ALA59 |
| A | ARG71 |
| A | SER251 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| A | GLY150 |
| A | HOH581 |
| B | ALA117 |
| B | VAL118 |
| B | THR119 |
| A | ARG147 |
| A | LYS148 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for Ligand residues SLL B 120 through TYR B 121 bound to THR B 119 |
| Chain | Residue |
| A | TYR102 |
| A | ARG105 |
| A | GLU113 |
| A | PRO114 |
| A | ARG119 |
| A | ILE142 |
| A | HIS158 |
| A | VAL221 |
| A | TRP222 |
| A | PHE223 |
| A | GLY224 |
| A | GLU225 |
| A | VAL253 |
| A | VAL254 |
| A | TYR255 |
| A | HOH559 |
| A | HOH569 |
| B | THR119 |
| B | THR122 |
| B | HOH302 |
| B | HOH304 |
| B | HOH307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29180469","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22076378","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22767592","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human sirtuin homolog 5 in complex with NAD.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
