6A9A
Ternary complex crystal structure of dCH with dCMP and THF
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0047153 | molecular_function | deoxycytidylate 5-hydroxymethyltransferase activity |
| A | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0099018 | biological_process | symbiont-mediated evasion of host restriction-modification system |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue DCM A 302 |
| Chain | Residue |
| A | LYS28 |
| A | GLY175 |
| A | ASN179 |
| A | HIS216 |
| A | TYR218 |
| A | THG303 |
| A | HOH408 |
| A | HOH501 |
| A | TYR96 |
| A | ARG123 |
| A | ARG124 |
| A | SER148 |
| A | ARG168 |
| A | SER169 |
| A | ASN170 |
| A | ASP171 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue THG A 303 |
| Chain | Residue |
| A | ASN53 |
| A | TYR56 |
| A | ARG59 |
| A | PRO79 |
| A | TRP82 |
| A | PHE174 |
| A | ARG177 |
| A | ASN178 |
| A | TYR218 |
| A | DCM302 |
| A | HOH401 |
| A | HOH402 |
| A | HOH403 |
| A | HOH404 |
| A | HOH405 |
| A | HOH410 |
| A | HOH413 |
| A | HOH414 |
| A | HOH415 |
| A | HOH473 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1420151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1420151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A9A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10064578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1B5E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 700 |
| Chain | Residue | Details |
| A | GLU60 | electrostatic stabiliser, proton acceptor, proton donor |
| A | SER148 | covalently attached, nucleofuge, nucleophile |
| A | ASN179 | electrostatic stabiliser, proton acceptor, proton donor |
