6A6E
Crystal structure of thermostable Cysteine desulfurase (FiSufS) from thermophilic Fervidobacterium Islandicum AW-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006534 | biological_process | cysteine metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0006534 | biological_process | cysteine metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| C | 0006534 | biological_process | cysteine metabolic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0031071 | molecular_function | cysteine desulfurase activity |
| D | 0006534 | biological_process | cysteine metabolic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0031071 | molecular_function | cysteine desulfurase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue PLP A 501 |
| Chain | Residue |
| A | THR99 |
| A | LYS232 |
| A | CIT503 |
| A | HOH1239 |
| B | THR283 |
| A | THR100 |
| A | HIS129 |
| A | ASN183 |
| A | ASP206 |
| A | ALA208 |
| A | GLN209 |
| A | SER229 |
| A | HIS231 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ASN59 |
| A | ILE60 |
| A | HIS61 |
| A | ARG62 |
| A | GLY259 |
| A | GLU260 |
| A | GLY282 |
| A | THR283 |
| A | HOH1332 |
| A | HOH1347 |
| B | CSS372 |
| B | CIT502 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 503 |
| Chain | Residue |
| A | ALA37 |
| A | HIS129 |
| A | ASN183 |
| A | LYS232 |
| A | ARG394 |
| A | PLP501 |
| A | HOH1202 |
| A | HOH1271 |
| A | HOH1274 |
| B | ASN59 |
| B | THR283 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | ASP17 |
| A | TYR298 |
| A | SER301 |
| A | HOH1241 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | LEU15 |
| A | ASN16 |
| A | LYS22 |
| A | HOH1277 |
| A | HOH1325 |
| A | HOH1452 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue CIT A 506 |
| Chain | Residue |
| A | HIS61 |
| A | ARG62 |
| A | GLU260 |
| A | ASN273 |
| A | TYR277 |
| A | HOH1208 |
| A | HOH1236 |
| A | HOH1316 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | ARG195 |
| A | LYS199 |
| A | ASN200 |
| A | ALA201 |
| A | ASP224 |
| A | LYS245 |
| A | LEU248 |
| A | HOH1232 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 508 |
| Chain | Residue |
| A | VAL349 |
| A | HIS350 |
| A | ASP387 |
| A | PRO389 |
| A | HOH1406 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue PEG A 509 |
| Chain | Residue |
| A | ALA111 |
| A | LYS112 |
| A | TYR143 |
| A | HOH1207 |
| B | PHE142 |
| B | PEG503 |
| B | HOH814 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | ASP353 |
| C | HIS350 |
| C | PRO389 |
| C | CIT505 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 511 |
| Chain | Residue |
| A | GLY303 |
| A | PHE304 |
| A | GLU305 |
| A | LYS306 |
| A | HOH1400 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 512 |
| Chain | Residue |
| A | VAL73 |
| A | HOH1291 |
| A | HOH1395 |
| A | HOH1426 |
| site_id | AD4 |
| Number of Residues | 15 |
| Details | binding site for residue CIT B 502 |
| Chain | Residue |
| B | HOH619 |
| B | HOH625 |
| B | HOH714 |
| A | ASN59 |
| A | ILE60 |
| A | HIS61 |
| A | ARG62 |
| A | GOL502 |
| A | HOH1347 |
| B | ALA37 |
| B | HIS129 |
| B | ARG367 |
| B | HIS371 |
| B | CSS372 |
| B | ARG394 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 503 |
| Chain | Residue |
| A | PEG509 |
| B | LYS141 |
| B | PHE142 |
| B | HOH882 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 504 |
| Chain | Residue |
| A | VAL147 |
| A | HOH1328 |
| B | PHE267 |
| B | GLU268 |
| B | HOH656 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue PEG B 505 |
| Chain | Residue |
| B | THR151 |
| B | LYS165 |
| B | SER169 |
| B | ILE170 |
| B | HOH615 |
| B | HOH620 |
| B | HOH796 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | HIS350 |
| B | PRO351 |
| B | HIS352 |
| B | SER391 |
| B | HOH638 |
| B | HOH836 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | ASN59 |
| C | ILE60 |
| C | ARG62 |
| C | GLU260 |
| C | THR283 |
| C | HOH610 |
| D | CSS372 |
| D | CIT505 |
| D | HOH767 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | PHE142 |
| C | TYR143 |
| D | TYR143 |
| D | HOH612 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | ARG195 |
| C | LYS199 |
| C | ALA201 |
| C | THR202 |
| C | ASP224 |
| C | LYS245 |
| C | HOH855 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for residue CIT C 505 |
| Chain | Residue |
| A | HIS356 |
| A | GLU360 |
| A | ASN361 |
| A | GOL510 |
| C | HIS350 |
| C | HIS352 |
| C | SER368 |
| C | GLY369 |
| C | SER391 |
| C | HOH651 |
| D | ARG62 |
| site_id | AE4 |
| Number of Residues | 12 |
| Details | binding site for residue CIT C 506 |
| Chain | Residue |
| C | ALA37 |
| C | HIS129 |
| C | LYS232 |
| C | ARG367 |
| C | HIS371 |
| C | ARG394 |
| C | PLP501 |
| C | HOH606 |
| C | HOH774 |
| D | ASN59 |
| D | ILE60 |
| D | GOL503 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue PEG C 507 |
| Chain | Residue |
| C | SER113 |
| C | GLN251 |
| C | PEG508 |
| C | HOH756 |
| D | GOL502 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 508 |
| Chain | Residue |
| C | ILE115 |
| C | GLN251 |
| C | PEG507 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue CIT C 509 |
| Chain | Residue |
| C | HIS61 |
| C | ARG62 |
| C | THR72 |
| C | GLU76 |
| C | GLU260 |
| C | ASN273 |
| C | TYR277 |
| C | HOH618 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 510 |
| Chain | Residue |
| B | GLU91 |
| B | HOH654 |
| C | ARG418 |
| C | HOH835 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| C | PEG507 |
| D | PHE142 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| C | CSS372 |
| C | CIT506 |
| D | ASN59 |
| D | ILE60 |
| D | GLU260 |
| D | THR283 |
| D | HOH662 |
| site_id | AF2 |
| Number of Residues | 10 |
| Details | binding site for residue CIT D 504 |
| Chain | Residue |
| D | HIS61 |
| D | ARG62 |
| D | THR72 |
| D | GLU76 |
| D | GLU260 |
| D | ASN273 |
| D | TYR277 |
| D | HOH646 |
| D | HOH774 |
| D | HOH778 |
| site_id | AF3 |
| Number of Residues | 14 |
| Details | binding site for residue CIT D 505 |
| Chain | Residue |
| C | ASN59 |
| C | ILE60 |
| C | ARG62 |
| C | GOL502 |
| D | ALA37 |
| D | HIS129 |
| D | ARG367 |
| D | HIS371 |
| D | CSS372 |
| D | ARG394 |
| D | PLP501 |
| D | HOH604 |
| D | HOH632 |
| D | HOH767 |
| site_id | AF4 |
| Number of Residues | 8 |
| Details | binding site for residue CIT D 506 |
| Chain | Residue |
| D | HIS350 |
| D | PRO351 |
| D | HIS352 |
| D | SER368 |
| D | GLY369 |
| D | PRO389 |
| D | SER391 |
| D | HOH763 |
| site_id | AF5 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide PLP B 501 and LYS B 232 |
| Chain | Residue |
| A | THR283 |
| A | HOH1347 |
| B | ALA36 |
| B | ALA37 |
| B | THR39 |
| B | THR99 |
| B | THR100 |
| B | HIS129 |
| B | ASN183 |
| B | ASP206 |
| B | ALA208 |
| B | GLN209 |
| B | PRO212 |
| B | SER229 |
| B | GLY230 |
| B | HIS231 |
| B | ILE233 |
| B | LEU234 |
| B | HOH625 |
| B | HOH649 |
| B | HOH769 |
| site_id | AF6 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide PLP C 501 and LYS C 232 |
| Chain | Residue |
| C | ALA36 |
| C | ALA37 |
| C | THR39 |
| C | THR99 |
| C | THR100 |
| C | HIS129 |
| C | ASN183 |
| C | ASP206 |
| C | ALA208 |
| C | GLN209 |
| C | PRO212 |
| C | SER229 |
| C | GLY230 |
| C | HIS231 |
| C | ILE233 |
| C | LEU234 |
| C | CIT506 |
| C | HOH660 |
| C | HOH739 |
| C | HOH783 |
| D | THR283 |
| site_id | AF7 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide PLP D 501 and LYS D 232 |
| Chain | Residue |
| C | THR283 |
| D | ALA36 |
| D | ALA37 |
| D | THR39 |
| D | THR99 |
| D | THR100 |
| D | HIS129 |
| D | ASN183 |
| D | ASP206 |
| D | ALA208 |
| D | GLN209 |
| D | PRO212 |
| D | SER229 |
| D | GLY230 |
| D | HIS231 |
| D | ILE233 |
| D | LEU234 |
| D | CIT505 |
| D | HOH615 |
| D | HOH632 |
| D | HOH767 |
| D | HOH793 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. VDFLvfSGHKilgpt.GiGvL |
| Chain | Residue | Details |
| A | VAL223-LEU242 |
