6A6E
Crystal structure of thermostable Cysteine desulfurase (FiSufS) from thermophilic Fervidobacterium Islandicum AW-1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006534 | biological_process | cysteine metabolic process |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0031071 | molecular_function | cysteine desulfurase activity |
B | 0006534 | biological_process | cysteine metabolic process |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0031071 | molecular_function | cysteine desulfurase activity |
C | 0006534 | biological_process | cysteine metabolic process |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0031071 | molecular_function | cysteine desulfurase activity |
D | 0006534 | biological_process | cysteine metabolic process |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0031071 | molecular_function | cysteine desulfurase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue PLP A 501 |
Chain | Residue |
A | THR99 |
A | LYS232 |
A | CIT503 |
A | HOH1239 |
B | THR283 |
A | THR100 |
A | HIS129 |
A | ASN183 |
A | ASP206 |
A | ALA208 |
A | GLN209 |
A | SER229 |
A | HIS231 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | ASN59 |
A | ILE60 |
A | HIS61 |
A | ARG62 |
A | GLY259 |
A | GLU260 |
A | GLY282 |
A | THR283 |
A | HOH1332 |
A | HOH1347 |
B | CSS372 |
B | CIT502 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue CIT A 503 |
Chain | Residue |
A | ALA37 |
A | HIS129 |
A | ASN183 |
A | LYS232 |
A | ARG394 |
A | PLP501 |
A | HOH1202 |
A | HOH1271 |
A | HOH1274 |
B | ASN59 |
B | THR283 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue PEG A 504 |
Chain | Residue |
A | ASP17 |
A | TYR298 |
A | SER301 |
A | HOH1241 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | LEU15 |
A | ASN16 |
A | LYS22 |
A | HOH1277 |
A | HOH1325 |
A | HOH1452 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue CIT A 506 |
Chain | Residue |
A | HIS61 |
A | ARG62 |
A | GLU260 |
A | ASN273 |
A | TYR277 |
A | HOH1208 |
A | HOH1236 |
A | HOH1316 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue GOL A 507 |
Chain | Residue |
A | ARG195 |
A | LYS199 |
A | ASN200 |
A | ALA201 |
A | ASP224 |
A | LYS245 |
A | LEU248 |
A | HOH1232 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue PEG A 508 |
Chain | Residue |
A | VAL349 |
A | HIS350 |
A | ASP387 |
A | PRO389 |
A | HOH1406 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue PEG A 509 |
Chain | Residue |
A | ALA111 |
A | LYS112 |
A | TYR143 |
A | HOH1207 |
B | PHE142 |
B | PEG503 |
B | HOH814 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL A 510 |
Chain | Residue |
A | ASP353 |
C | HIS350 |
C | PRO389 |
C | CIT505 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue PEG A 511 |
Chain | Residue |
A | GLY303 |
A | PHE304 |
A | GLU305 |
A | LYS306 |
A | HOH1400 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue PEG A 512 |
Chain | Residue |
A | VAL73 |
A | HOH1291 |
A | HOH1395 |
A | HOH1426 |
site_id | AD4 |
Number of Residues | 15 |
Details | binding site for residue CIT B 502 |
Chain | Residue |
B | HOH619 |
B | HOH625 |
B | HOH714 |
A | ASN59 |
A | ILE60 |
A | HIS61 |
A | ARG62 |
A | GOL502 |
A | HOH1347 |
B | ALA37 |
B | HIS129 |
B | ARG367 |
B | HIS371 |
B | CSS372 |
B | ARG394 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue PEG B 503 |
Chain | Residue |
A | PEG509 |
B | LYS141 |
B | PHE142 |
B | HOH882 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue PEG B 504 |
Chain | Residue |
A | VAL147 |
A | HOH1328 |
B | PHE267 |
B | GLU268 |
B | HOH656 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue PEG B 505 |
Chain | Residue |
B | THR151 |
B | LYS165 |
B | SER169 |
B | ILE170 |
B | HOH615 |
B | HOH620 |
B | HOH796 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue GOL B 506 |
Chain | Residue |
B | HIS350 |
B | PRO351 |
B | HIS352 |
B | SER391 |
B | HOH638 |
B | HOH836 |
site_id | AD9 |
Number of Residues | 9 |
Details | binding site for residue GOL C 502 |
Chain | Residue |
C | ASN59 |
C | ILE60 |
C | ARG62 |
C | GLU260 |
C | THR283 |
C | HOH610 |
D | CSS372 |
D | CIT505 |
D | HOH767 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue GOL C 503 |
Chain | Residue |
C | PHE142 |
C | TYR143 |
D | TYR143 |
D | HOH612 |
site_id | AE2 |
Number of Residues | 7 |
Details | binding site for residue GOL C 504 |
Chain | Residue |
C | ARG195 |
C | LYS199 |
C | ALA201 |
C | THR202 |
C | ASP224 |
C | LYS245 |
C | HOH855 |
site_id | AE3 |
Number of Residues | 11 |
Details | binding site for residue CIT C 505 |
Chain | Residue |
A | HIS356 |
A | GLU360 |
A | ASN361 |
A | GOL510 |
C | HIS350 |
C | HIS352 |
C | SER368 |
C | GLY369 |
C | SER391 |
C | HOH651 |
D | ARG62 |
site_id | AE4 |
Number of Residues | 12 |
Details | binding site for residue CIT C 506 |
Chain | Residue |
C | ALA37 |
C | HIS129 |
C | LYS232 |
C | ARG367 |
C | HIS371 |
C | ARG394 |
C | PLP501 |
C | HOH606 |
C | HOH774 |
D | ASN59 |
D | ILE60 |
D | GOL503 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue PEG C 507 |
Chain | Residue |
C | SER113 |
C | GLN251 |
C | PEG508 |
C | HOH756 |
D | GOL502 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue PEG C 508 |
Chain | Residue |
C | ILE115 |
C | GLN251 |
C | PEG507 |
site_id | AE7 |
Number of Residues | 8 |
Details | binding site for residue CIT C 509 |
Chain | Residue |
C | HIS61 |
C | ARG62 |
C | THR72 |
C | GLU76 |
C | GLU260 |
C | ASN273 |
C | TYR277 |
C | HOH618 |
site_id | AE8 |
Number of Residues | 4 |
Details | binding site for residue PEG C 510 |
Chain | Residue |
B | GLU91 |
B | HOH654 |
C | ARG418 |
C | HOH835 |
site_id | AE9 |
Number of Residues | 2 |
Details | binding site for residue GOL D 502 |
Chain | Residue |
C | PEG507 |
D | PHE142 |
site_id | AF1 |
Number of Residues | 7 |
Details | binding site for residue GOL D 503 |
Chain | Residue |
C | CSS372 |
C | CIT506 |
D | ASN59 |
D | ILE60 |
D | GLU260 |
D | THR283 |
D | HOH662 |
site_id | AF2 |
Number of Residues | 10 |
Details | binding site for residue CIT D 504 |
Chain | Residue |
D | HIS61 |
D | ARG62 |
D | THR72 |
D | GLU76 |
D | GLU260 |
D | ASN273 |
D | TYR277 |
D | HOH646 |
D | HOH774 |
D | HOH778 |
site_id | AF3 |
Number of Residues | 14 |
Details | binding site for residue CIT D 505 |
Chain | Residue |
C | ASN59 |
C | ILE60 |
C | ARG62 |
C | GOL502 |
D | ALA37 |
D | HIS129 |
D | ARG367 |
D | HIS371 |
D | CSS372 |
D | ARG394 |
D | PLP501 |
D | HOH604 |
D | HOH632 |
D | HOH767 |
site_id | AF4 |
Number of Residues | 8 |
Details | binding site for residue CIT D 506 |
Chain | Residue |
D | HIS350 |
D | PRO351 |
D | HIS352 |
D | SER368 |
D | GLY369 |
D | PRO389 |
D | SER391 |
D | HOH763 |
site_id | AF5 |
Number of Residues | 21 |
Details | binding site for Di-peptide PLP B 501 and LYS B 232 |
Chain | Residue |
A | THR283 |
A | HOH1347 |
B | ALA36 |
B | ALA37 |
B | THR39 |
B | THR99 |
B | THR100 |
B | HIS129 |
B | ASN183 |
B | ASP206 |
B | ALA208 |
B | GLN209 |
B | PRO212 |
B | SER229 |
B | GLY230 |
B | HIS231 |
B | ILE233 |
B | LEU234 |
B | HOH625 |
B | HOH649 |
B | HOH769 |
site_id | AF6 |
Number of Residues | 21 |
Details | binding site for Di-peptide PLP C 501 and LYS C 232 |
Chain | Residue |
C | ALA36 |
C | ALA37 |
C | THR39 |
C | THR99 |
C | THR100 |
C | HIS129 |
C | ASN183 |
C | ASP206 |
C | ALA208 |
C | GLN209 |
C | PRO212 |
C | SER229 |
C | GLY230 |
C | HIS231 |
C | ILE233 |
C | LEU234 |
C | CIT506 |
C | HOH660 |
C | HOH739 |
C | HOH783 |
D | THR283 |
site_id | AF7 |
Number of Residues | 22 |
Details | binding site for Di-peptide PLP D 501 and LYS D 232 |
Chain | Residue |
C | THR283 |
D | ALA36 |
D | ALA37 |
D | THR39 |
D | THR99 |
D | THR100 |
D | HIS129 |
D | ASN183 |
D | ASP206 |
D | ALA208 |
D | GLN209 |
D | PRO212 |
D | SER229 |
D | GLY230 |
D | HIS231 |
D | ILE233 |
D | LEU234 |
D | CIT505 |
D | HOH615 |
D | HOH632 |
D | HOH767 |
D | HOH793 |
Functional Information from PROSITE/UniProt
site_id | PS00595 |
Number of Residues | 20 |
Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. VDFLvfSGHKilgpt.GiGvL |
Chain | Residue | Details |
A | VAL223-LEU242 |