6A5Z

Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
D	0003677	molecular_function	DNA binding
D	0003707	molecular_function	nuclear steroid receptor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
H	0003677	molecular_function	DNA binding
H	0004879	molecular_function	nuclear receptor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0032052	molecular_function	bile acid binding
H	0038183	biological_process	bile acid signaling pathway
L	0003677	molecular_function	DNA binding
L	0003707	molecular_function	nuclear steroid receptor activity
L	0005634	cellular_component	nucleus
L	0006355	biological_process	regulation of DNA-templated transcription
L	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 9R3 A 501

Chain	Residue
A	MET290
A	TRP454
A	PHE461
A	MET328
A	PHE329
A	ARG331
A	SER332
A	ILE335
A	TYR369
A	HIS447
A	MET450

---

site_id	AC2
Number of Residues	8
Details	binding site for residue 9CR D 501

Chain	Residue
D	ILE268
D	ALA271
D	ALA272
D	PHE313
D	ARG316
D	LEU326
D	ALA327
D	CYS432

---

site_id	AC3
Number of Residues	13
Details	binding site for residue 9R3 H 501

Chain	Residue
H	MET265
H	MET290
H	MET328
H	PHE329
H	SER332
H	ILE335
H	LEU348
H	TYR369
H	HIS447
H	TRP454
H	PHE461
H	LEU465
H	TRP469

---

site_id	AC4
Number of Residues	9
Details	binding site for residue 9CR L 501

Chain	Residue
L	ILE268
L	ALA271
L	ALA272
L	GLN275
L	PHE313
L	ARG316
L	LEU326
L	ALA327
L	ILE345

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---