6A5Z
Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| H | 0003677 | molecular_function | DNA binding |
| H | 0004879 | molecular_function | nuclear receptor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0032052 | molecular_function | bile acid binding |
| H | 0038183 | biological_process | bile acid signaling pathway |
| L | 0003677 | molecular_function | DNA binding |
| L | 0003707 | molecular_function | nuclear steroid receptor activity |
| L | 0005634 | cellular_component | nucleus |
| L | 0006355 | biological_process | regulation of DNA-templated transcription |
| L | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 9R3 A 501 |
| Chain | Residue |
| A | MET290 |
| A | TRP454 |
| A | PHE461 |
| A | MET328 |
| A | PHE329 |
| A | ARG331 |
| A | SER332 |
| A | ILE335 |
| A | TYR369 |
| A | HIS447 |
| A | MET450 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 9CR D 501 |
| Chain | Residue |
| D | ILE268 |
| D | ALA271 |
| D | ALA272 |
| D | PHE313 |
| D | ARG316 |
| D | LEU326 |
| D | ALA327 |
| D | CYS432 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 9R3 H 501 |
| Chain | Residue |
| H | MET265 |
| H | MET290 |
| H | MET328 |
| H | PHE329 |
| H | SER332 |
| H | ILE335 |
| H | LEU348 |
| H | TYR369 |
| H | HIS447 |
| H | TRP454 |
| H | PHE461 |
| H | LEU465 |
| H | TRP469 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue 9CR L 501 |
| Chain | Residue |
| L | ILE268 |
| L | ALA271 |
| L | ALA272 |
| L | GLN275 |
| L | PHE313 |
| L | ARG316 |
| L | LEU326 |
| L | ALA327 |
| L | ILE345 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER757 | |
| F | SER641 | |
| G | SER757 | |
| I | SER641 | |
| H | ARG331 | |
| H | TYR361 | |
| H | TYR369 | |
| H | HIS447 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| D | SER259 | |
| L | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| D | SER260 | |
| L | SER260 | |
| H | LYS275 |
