6A57
Structure of histone demethylase REF6 complexed with DNA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1401 |
| Chain | Residue |
| A | CYS1245 |
| A | CYS1250 |
| A | HIS1263 |
| A | HIS1280 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1402 |
| Chain | Residue |
| A | CYS1268 |
| A | CYS1273 |
| A | HIS1286 |
| A | HIS1290 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1403 |
| Chain | Residue |
| A | CYS1303 |
| A | HIS1316 |
| A | HIS1320 |
| A | CYS1298 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1404 |
| Chain | Residue |
| A | CYS1328 |
| A | CYS1333 |
| A | HIS1346 |
| A | HIS1352 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 101 |
| Chain | Residue |
| A | HIS1290 |
| A | ASP1292 |
| C | DG33 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 23 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CpikgCgknFfshkylvqHqrv..H |
| Chain | Residue | Details |
| A | CYS1268-HIS1290 | |
| A | CYS1298-HIS1320 | |
| A | CYS1328-HIS1352 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | ZN_FING: C2H2-type 1; degenerate => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR1243-ASN1266 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | ASN1266-HIS1290 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | LEU1296-HIS1320 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | ZN_FING: C2H2-type 4 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| A | TYR1326-HIS1352 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32257379, ECO:0007744|PDB:6A57, ECO:0007744|PDB:6A58, ECO:0007744|PDB:6A59 |
| Chain | Residue | Details |
| A | CYS1245 | |
| A | CYS1250 | |
| A | HIS1263 | |
| A | HIS1280 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31048693, ECO:0000269|PubMed:32257379, ECO:0007744|PDB:6A57, ECO:0007744|PDB:6A58, ECO:0007744|PDB:6A59, ECO:0007744|PDB:6JNL, ECO:0007744|PDB:6JNN |
| Chain | Residue | Details |
| A | CYS1268 | |
| A | CYS1273 | |
| A | HIS1286 | |
| A | HIS1290 | |
| A | CYS1298 | |
| A | CYS1303 | |
| A | HIS1316 | |
| A | HIS1320 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31048693, ECO:0000269|PubMed:32257379, ECO:0007744|PDB:6A57, ECO:0007744|PDB:6A58, ECO:0007744|PDB:6A59, ECO:0007744|PDB:6JNL, ECO:0007744|PDB:6JNM, ECO:0007744|PDB:6JNN |
| Chain | Residue | Details |
| A | CYS1328 | |
| A | CYS1333 | |
| A | HIS1346 | |
| A | HIS1352 |
