6A47

Structure of TREX2 in complex with a Y structured dsDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006308	biological_process	DNA catabolic process
A	0006974	biological_process	DNA damage response
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0006308	biological_process	DNA catabolic process
B	0006974	biological_process	DNA damage response
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 301

Chain	Residue
A	ASP14
A	GLU16
A	ASP193
C	DT23

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 302

Chain	Residue
A	GLU29
A	SER189
A	ALA190
A	GLU191

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 301

Chain	Residue
B	GLU16
B	ASP193
D	DT23
B	ASP14

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG C 101

Chain	Residue
A	ASP14
A	HOH414
A	HOH437
A	HOH502
C	DT22
C	DT23

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG D 101

Chain	Residue
B	ASP14
B	HOH416
B	HOH448
B	HOH526
D	DT22
D	DT23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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