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6A2J

Crystal structure of heme A synthase from Bacillus subtilis

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006783biological_processheme biosynthetic process
A0006784biological_processheme A biosynthetic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016653molecular_functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue HEM A 601
ChainResidue
AARG37
AALA220
AILE255
AGLN258
AALA259
AGLY262
ALEU270
AHIS278
AHOH701
AHOH703
AHOH709
APHE124
AHOH719
AVAL176
AGLY179
AALA180
AARG183
ASER188
AHIS216
AARG217

site_idAC2
Number of Residues4
Detailsbinding site for residue CU A 602
ChainResidue
AGLU-2
AMET-4
AASP145
AHIS209

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 A 603
ChainResidue
ATHR27
ALYS28
ATHR29
AARG183
AHIS184

site_idAC4
Number of Residues6
Detailsbinding site for residue SO4 A 604
ChainResidue
AGLY158
ALYS159
ALYS160
AMET161
AHIS233
ATYR238

site_idAC5
Number of Residues6
Detailsbinding site for residue SO4 A 605
ChainResidue
AGLU-2
AASP-1
AASN2
AGLN207
APHE208
AOLC624

site_idAC6
Number of Residues9
Detailsbinding site for residue OLC A 606
ChainResidue
AARG87
AGLU88
APHE91
ALEU92
AMET95
APHE286
ACYS290
AOLC610
AOLC618

site_idAC7
Number of Residues8
Detailsbinding site for residue OLC A 607
ChainResidue
AGLN38
ATRP39
ALYS242
AGLN243
ATRP246
AGLY247
ATYR291
AOLC619

site_idAC8
Number of Residues6
Detailsbinding site for residue OLC A 608
ChainResidue
ALEU139
APHE142
AGLU143
ALYS146
ATHR150
AOLC612

site_idAC9
Number of Residues1
Detailsbinding site for residue OLC A 609
ChainResidue
APRO195

site_idAD1
Number of Residues4
Detailsbinding site for residue OLC A 610
ChainResidue
AILE94
AILE98
AOLC606
AOLC611

site_idAD2
Number of Residues5
Detailsbinding site for residue OLC A 611
ChainResidue
ALYS159
AGLN162
APHE163
AOLC610
AOLC616

site_idAD3
Number of Residues5
Detailsbinding site for residue OLC A 612
ChainResidue
ALYS6
AVAL10
APHE142
ALYS146
AOLC608

site_idAD4
Number of Residues1
Detailsbinding site for residue OLC A 613
ChainResidue
AOLC620

site_idAD5
Number of Residues5
Detailsbinding site for residue OLC A 614
ChainResidue
AILE235
ALYS239
APHE245
ALEU252
ATHR256

site_idAD6
Number of Residues8
Detailsbinding site for residue OLC A 615
ChainResidue
APHE14
ALEU17
AALA271
AGLY273
APHE274
AALA277
APHE280
AOLC622

site_idAD7
Number of Residues2
Detailsbinding site for residue OLC A 616
ChainResidue
AOLC611
AOLC617

site_idAD8
Number of Residues5
Detailsbinding site for residue OLC A 617
ChainResidue
AOLC618
AILE166
AALA297
AARG300
AOLC616

site_idAD9
Number of Residues4
Detailsbinding site for residue OLC A 618
ChainResidue
ATYR173
ALEU293
AOLC606
AOLC617

site_idAE1
Number of Residues3
Detailsbinding site for residue OLC A 619
ChainResidue
ALEU17
ACYS284
AOLC607

site_idAE2
Number of Residues2
Detailsbinding site for residue OLC A 620
ChainResidue
AOLC613
AOLC621

site_idAE3
Number of Residues9
Detailsbinding site for residue OLC A 621
ChainResidue
APHE76
AARG80
AHIS164
AVAL229
AVAL232
AHIS233
ATHR236
ASER237
AOLC620

site_idAE4
Number of Residues7
Detailsbinding site for residue OLC A 622
ChainResidue
AMET264
ATYR267
ASER268
APHE274
AOLC615
AOLC623
AHOH730

site_idAE5
Number of Residues3
Detailsbinding site for residue OLC A 623
ChainResidue
ATYR267
AGLU302
AOLC622

site_idAE6
Number of Residues7
Detailsbinding site for residue OLC A 624
ChainResidue
AVAL112
ATHR206
APHE208
ATRP211
AGLY215
ASO4605
AOLC625

site_idAE7
Number of Residues6
Detailsbinding site for residue OLC A 625
ChainResidue
AALA108
ALEU204
APRO205
ATHR206
ATRP211
AOLC624

site_idAE8
Number of Residues3
Detailsbinding site for residue OLC A 626
ChainResidue
ATRP39
APHE46
ATRP246

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues34
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30397130
ChainResidueDetails
AMET1-ASN2
ATRP79-GLU88
ALEU140-LYS159
ASER237-LYS242

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
ALYS3-LEU25

site_idSWS_FT_FI3
Number of Residues52
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:30397130
ChainResidueDetails
AVAL26-ASN51
AGLY114-SER115
AGLU186-GLU210
AGLU269-ALA271

site_idSWS_FT_FI4
Number of Residues26
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
APRO52-SER78

site_idSWS_FT_FI5
Number of Residues24
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
ATHR89-PHE113

site_idSWS_FT_FI6
Number of Residues23
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
AASN116-LEU139

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
ALYS160-THR185

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
ATRP211-THR236

site_idSWS_FT_FI9
Number of Residues25
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
AGLN243-SER268

site_idSWS_FT_FI10
Number of Residues22
DetailsTRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
ALEU272-LEU294

site_idSWS_FT_FI11
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01664, ECO:0000305|PubMed:30397130
ChainResidueDetails
AGLU57

site_idSWS_FT_FI12
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_01664, ECO:0000305|PubMed:30397130
ChainResidueDetails
AHIS60
AHIS123

site_idSWS_FT_FI13
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000255|HAMAP-Rule:MF_01664, ECO:0000269|PubMed:30397130, ECO:0007744|PDB:6A2J, ECO:0007744|PDB:6IED
ChainResidueDetails
AHIS216
AHIS278

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PDB entries from 2024-10-16

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