Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6A10

Crystal structure of hen egg white lysozyme crystallized by ammonium sulfate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
B	0003796	molecular_function	lysozyme activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0016231	molecular_function	beta-N-acetylglucosaminidase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0016998	biological_process	cell wall macromolecule catabolic process
B	0031640	biological_process	killing of cells of another organism
B	0042742	biological_process	defense response to bacterium
B	0042802	molecular_function	identical protein binding
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
C	0003796	molecular_function	lysozyme activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0016231	molecular_function	beta-N-acetylglucosaminidase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0016998	biological_process	cell wall macromolecule catabolic process
C	0031640	biological_process	killing of cells of another organism
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG14
A	HIS15
A	HOH333
A	HOH347
B	GLY4
B	ARG5
B	CYS6
B	GLU7

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	HOH301
A	HOH302
C	ARG114
A	ASN74

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLY71
A	ARG73
A	HOH316
A	HOH351
A	HOH376
C	ASN37
C	HOH391

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 A 204

Chain	Residue
A	PHE34
A	ARG114
A	HOH303
A	HOH310
A	HOH384
A	HOH391
B	ASN74
B	HOH416

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 B 201

Chain	Residue
B	ARG14
B	HIS15
B	HOH353
B	HOH370
B	HOH374
B	HOH380

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 B 202

Chain	Residue
A	ASN37
B	GLY71
B	ARG73
B	HOH304
B	HOH322
B	HOH323
B	HOH348
B	HOH399

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 B 203

Chain	Residue
B	ARG114
B	HOH311
C	ASN74
C	HOH341

site_id	AC8
Number of Residues	1
Details	binding site for residue SO4 C 201

Chain	Residue
C	ARG5

site_id	AC9
Number of Residues	10
Details	binding site for residue SO4 C 202

Chain	Residue
A	GLY4
A	ARG5
A	CYS6
A	GLU7
C	ARG14
C	HIS15
C	HOH328
C	HOH363
C	HOH368
C	HOH434

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 C 203

Chain	Residue
B	GLN41
C	ARG125
C	GLY126
C	CYS127
C	ARG128
C	HOH312
C	HOH355
C	HOH407

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52
B	GLU35
B	ASP52
C	GLU35
C	ASP52

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP101
B	ASP101
C	ASP101

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

site_id	MCSA2
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
B	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	ASN46
B	ASP48
B	SER50
B	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
B	ASN59

site_id	MCSA3
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
C	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	ASN46
C	ASP48
C	SER50
C	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
C	ASN59

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)