5ZQV

Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0001111	biological_process	RNA polymerase II promoter clearance
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005811	cellular_component	lipid droplet
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005912	cellular_component	adherens junction
A	0005977	biological_process	glycogen metabolic process
A	0005979	biological_process	regulation of glycogen biosynthetic process
A	0005981	biological_process	regulation of glycogen catabolic process
A	0006366	biological_process	transcription by RNA polymerase II
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006417	biological_process	regulation of translation
A	0006470	biological_process	protein dephosphorylation
A	0008157	molecular_function	protein phosphatase 1 binding
A	0010288	biological_process	response to lead ion
A	0010897	biological_process	negative regulation of triglyceride catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030324	biological_process	lung development
A	0032922	biological_process	circadian regulation of gene expression
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
A	0042587	cellular_component	glycogen granule
A	0042752	biological_process	regulation of circadian rhythm
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0043025	cellular_component	neuronal cell body
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043197	cellular_component	dendritic spine
A	0043204	cellular_component	perikaryon
A	0043247	biological_process	telomere maintenance in response to DNA damage
A	0044877	molecular_function	protein-containing complex binding
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048511	biological_process	rhythmic process
A	0048754	biological_process	branching morphogenesis of an epithelial tube
A	0050821	biological_process	protein stabilization
A	0051301	biological_process	cell division
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0097225	cellular_component	sperm midpiece
A	0097229	cellular_component	sperm end piece
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0098609	biological_process	cell-cell adhesion
A	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
A	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0001111	biological_process	RNA polymerase II promoter clearance
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005811	cellular_component	lipid droplet
B	0005814	cellular_component	centriole
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005912	cellular_component	adherens junction
B	0005977	biological_process	glycogen metabolic process
B	0005979	biological_process	regulation of glycogen biosynthetic process
B	0005981	biological_process	regulation of glycogen catabolic process
B	0006366	biological_process	transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006417	biological_process	regulation of translation
B	0006470	biological_process	protein dephosphorylation
B	0008157	molecular_function	protein phosphatase 1 binding
B	0010288	biological_process	response to lead ion
B	0010897	biological_process	negative regulation of triglyceride catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030324	biological_process	lung development
B	0032922	biological_process	circadian regulation of gene expression
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
B	0042587	cellular_component	glycogen granule
B	0042752	biological_process	regulation of circadian rhythm
B	0043021	molecular_function	ribonucleoprotein complex binding
B	0043025	cellular_component	neuronal cell body
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0043197	cellular_component	dendritic spine
B	0043204	cellular_component	perikaryon
B	0043247	biological_process	telomere maintenance in response to DNA damage
B	0044877	molecular_function	protein-containing complex binding
B	0045725	biological_process	positive regulation of glycogen biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048511	biological_process	rhythmic process
B	0048754	biological_process	branching morphogenesis of an epithelial tube
B	0050821	biological_process	protein stabilization
B	0051301	biological_process	cell division
B	0072357	cellular_component	PTW/PP1 phosphatase complex
B	0097225	cellular_component	sperm midpiece
B	0097229	cellular_component	sperm end piece
B	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
B	0098609	biological_process	cell-cell adhesion
B	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
B	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	0000164	cellular_component	protein phosphatase type 1 complex
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0001111	biological_process	RNA polymerase II promoter clearance
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005811	cellular_component	lipid droplet
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005912	cellular_component	adherens junction
C	0005977	biological_process	glycogen metabolic process
C	0005979	biological_process	regulation of glycogen biosynthetic process
C	0005981	biological_process	regulation of glycogen catabolic process
C	0006366	biological_process	transcription by RNA polymerase II
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006417	biological_process	regulation of translation
C	0006470	biological_process	protein dephosphorylation
C	0008157	molecular_function	protein phosphatase 1 binding
C	0010288	biological_process	response to lead ion
C	0010897	biological_process	negative regulation of triglyceride catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030324	biological_process	lung development
C	0032922	biological_process	circadian regulation of gene expression
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
C	0042587	cellular_component	glycogen granule
C	0042752	biological_process	regulation of circadian rhythm
C	0043021	molecular_function	ribonucleoprotein complex binding
C	0043025	cellular_component	neuronal cell body
C	0043153	biological_process	entrainment of circadian clock by photoperiod
C	0043197	cellular_component	dendritic spine
C	0043204	cellular_component	perikaryon
C	0043247	biological_process	telomere maintenance in response to DNA damage
C	0044877	molecular_function	protein-containing complex binding
C	0045725	biological_process	positive regulation of glycogen biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
C	0048511	biological_process	rhythmic process
C	0048754	biological_process	branching morphogenesis of an epithelial tube
C	0050821	biological_process	protein stabilization
C	0051301	biological_process	cell division
C	0072357	cellular_component	PTW/PP1 phosphatase complex
C	0097225	cellular_component	sperm midpiece
C	0097229	cellular_component	sperm end piece
C	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
C	0098609	biological_process	cell-cell adhesion
C	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
C	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0000164	cellular_component	protein phosphatase type 1 complex
D	0000723	biological_process	telomere maintenance
D	0000781	cellular_component	chromosome, telomeric region
D	0001111	biological_process	RNA polymerase II promoter clearance
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005811	cellular_component	lipid droplet
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005912	cellular_component	adherens junction
D	0005977	biological_process	glycogen metabolic process
D	0005979	biological_process	regulation of glycogen biosynthetic process
D	0005981	biological_process	regulation of glycogen catabolic process
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006417	biological_process	regulation of translation
D	0006470	biological_process	protein dephosphorylation
D	0008157	molecular_function	protein phosphatase 1 binding
D	0010288	biological_process	response to lead ion
D	0010897	biological_process	negative regulation of triglyceride catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030324	biological_process	lung development
D	0032922	biological_process	circadian regulation of gene expression
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
D	0042587	cellular_component	glycogen granule
D	0042752	biological_process	regulation of circadian rhythm
D	0043021	molecular_function	ribonucleoprotein complex binding
D	0043025	cellular_component	neuronal cell body
D	0043153	biological_process	entrainment of circadian clock by photoperiod
D	0043197	cellular_component	dendritic spine
D	0043204	cellular_component	perikaryon
D	0043247	biological_process	telomere maintenance in response to DNA damage
D	0044877	molecular_function	protein-containing complex binding
D	0045725	biological_process	positive regulation of glycogen biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0046914	molecular_function	transition metal ion binding
D	0048511	biological_process	rhythmic process
D	0048754	biological_process	branching morphogenesis of an epithelial tube
D	0050821	biological_process	protein stabilization
D	0051301	biological_process	cell division
D	0072357	cellular_component	PTW/PP1 phosphatase complex
D	0097225	cellular_component	sperm midpiece
D	0097229	cellular_component	sperm end piece
D	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
D	0098609	biological_process	cell-cell adhesion
D	0098641	molecular_function	cadherin binding involved in cell-cell adhesion
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D	2000806	biological_process	positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
D	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 401

Chain	Residue
A	ASP92
A	ASN124
A	HIS173
A	HIS248
A	FLC402

---

site_id	AC2
Number of Residues	8
Details	binding site for residue FLC A 402

Chain	Residue
A	ARG221
A	HIS248
A	MN401
C	ARG132
A	ARG96
A	ASN124
A	HIS125
A	TYR134

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MN B 401

Chain	Residue
B	ASP92
B	ASN124
B	HIS173
B	HIS248

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MN C 401

Chain	Residue
C	ASP92
C	ASN124
C	HIS173
C	HIS248
C	FLC402

---

site_id	AC5
Number of Residues	8
Details	binding site for residue FLC C 402

Chain	Residue
A	ARG132
A	ILE133
C	ASN124
C	HIS125
C	TYR134
C	TRP206
C	ARG221
C	MN401

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MN D 401

Chain	Residue
D	ASP92
D	ASN124
D	HIS173
D	HIS248
D	FLC402

---

site_id	AC7
Number of Residues	9
Details	binding site for residue FLC D 402

Chain	Residue
B	ARG132
D	ARG96
D	ASN124
D	HIS125
D	TYR134
D	TRP206
D	ARG221
D	HIS248
D	MN401

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62136","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62136","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Motif: {"description":"PP1-binding motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"Q00756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---