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5ZQV

Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GM

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0000781cellular_componentchromosome, telomeric region
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005977biological_processglycogen metabolic process
A0005979biological_processregulation of glycogen biosynthetic process
A0005981biological_processregulation of glycogen catabolic process
A0006417biological_processregulation of translation
A0006470biological_processprotein dephosphorylation
A0007049biological_processcell cycle
A0008157molecular_functionprotein phosphatase 1 binding
A0010288biological_processresponse to lead ion
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0030324biological_processlung development
A0032922biological_processcircadian regulation of gene expression
A0042587cellular_componentglycogen granule
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0043153biological_processentrainment of circadian clock by photoperiod
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0044877molecular_functionprotein-containing complex binding
A0046872molecular_functionmetal ion binding
A0048511biological_processrhythmic process
A0048754biological_processbranching morphogenesis of an epithelial tube
A0051301biological_processcell division
A0072357cellular_componentPTW/PP1 phosphatase complex
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000164cellular_componentprotein phosphatase type 1 complex
B0000781cellular_componentchromosome, telomeric region
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0005977biological_processglycogen metabolic process
B0005979biological_processregulation of glycogen biosynthetic process
B0005981biological_processregulation of glycogen catabolic process
B0006417biological_processregulation of translation
B0006470biological_processprotein dephosphorylation
B0007049biological_processcell cycle
B0008157molecular_functionprotein phosphatase 1 binding
B0010288biological_processresponse to lead ion
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0017018molecular_functionmyosin phosphatase activity
B0030324biological_processlung development
B0032922biological_processcircadian regulation of gene expression
B0042587cellular_componentglycogen granule
B0042752biological_processregulation of circadian rhythm
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0043153biological_processentrainment of circadian clock by photoperiod
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044877molecular_functionprotein-containing complex binding
B0046872molecular_functionmetal ion binding
B0048511biological_processrhythmic process
B0048754biological_processbranching morphogenesis of an epithelial tube
B0051301biological_processcell division
B0072357cellular_componentPTW/PP1 phosphatase complex
B0098609biological_processcell-cell adhesion
B0098641molecular_functioncadherin binding involved in cell-cell adhesion
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
C0000164cellular_componentprotein phosphatase type 1 complex
C0000781cellular_componentchromosome, telomeric region
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005912cellular_componentadherens junction
C0005977biological_processglycogen metabolic process
C0005979biological_processregulation of glycogen biosynthetic process
C0005981biological_processregulation of glycogen catabolic process
C0006417biological_processregulation of translation
C0006470biological_processprotein dephosphorylation
C0007049biological_processcell cycle
C0008157molecular_functionprotein phosphatase 1 binding
C0010288biological_processresponse to lead ion
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0017018molecular_functionmyosin phosphatase activity
C0030324biological_processlung development
C0032922biological_processcircadian regulation of gene expression
C0042587cellular_componentglycogen granule
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043025cellular_componentneuronal cell body
C0043153biological_processentrainment of circadian clock by photoperiod
C0043197cellular_componentdendritic spine
C0043204cellular_componentperikaryon
C0044877molecular_functionprotein-containing complex binding
C0046872molecular_functionmetal ion binding
C0048511biological_processrhythmic process
C0048754biological_processbranching morphogenesis of an epithelial tube
C0051301biological_processcell division
C0072357cellular_componentPTW/PP1 phosphatase complex
C0098609biological_processcell-cell adhesion
C0098641molecular_functioncadherin binding involved in cell-cell adhesion
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0000164cellular_componentprotein phosphatase type 1 complex
D0000781cellular_componentchromosome, telomeric region
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0005977biological_processglycogen metabolic process
D0005979biological_processregulation of glycogen biosynthetic process
D0005981biological_processregulation of glycogen catabolic process
D0006417biological_processregulation of translation
D0006470biological_processprotein dephosphorylation
D0007049biological_processcell cycle
D0008157molecular_functionprotein phosphatase 1 binding
D0010288biological_processresponse to lead ion
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0017018molecular_functionmyosin phosphatase activity
D0030324biological_processlung development
D0032922biological_processcircadian regulation of gene expression
D0042587cellular_componentglycogen granule
D0042752biological_processregulation of circadian rhythm
D0043021molecular_functionribonucleoprotein complex binding
D0043025cellular_componentneuronal cell body
D0043153biological_processentrainment of circadian clock by photoperiod
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0044877molecular_functionprotein-containing complex binding
D0046872molecular_functionmetal ion binding
D0048511biological_processrhythmic process
D0048754biological_processbranching morphogenesis of an epithelial tube
D0051301biological_processcell division
D0072357cellular_componentPTW/PP1 phosphatase complex
D0098609biological_processcell-cell adhesion
D0098641molecular_functioncadherin binding involved in cell-cell adhesion
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MN A 401
ChainResidue
AASP92
AASN124
AHIS173
AHIS248
AFLC402

site_idAC2
Number of Residues8
Detailsbinding site for residue FLC A 402
ChainResidue
AARG221
AHIS248
AMN401
CARG132
AARG96
AASN124
AHIS125
ATYR134

site_idAC3
Number of Residues4
Detailsbinding site for residue MN B 401
ChainResidue
BASP92
BASN124
BHIS173
BHIS248

site_idAC4
Number of Residues5
Detailsbinding site for residue MN C 401
ChainResidue
CASP92
CASN124
CHIS173
CHIS248
CFLC402

site_idAC5
Number of Residues8
Detailsbinding site for residue FLC C 402
ChainResidue
AARG132
AILE133
CASN124
CHIS125
CTYR134
CTRP206
CARG221
CMN401

site_idAC6
Number of Residues5
Detailsbinding site for residue MN D 401
ChainResidue
DASP92
DASN124
DHIS173
DHIS248
DFLC402

site_idAC7
Number of Residues9
Detailsbinding site for residue FLC D 402
ChainResidue
BARG132
DARG96
DASN124
DHIS125
DTYR134
DTRP206
DARG221
DHIS248
DMN401

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphoserine; by GSK3 => ECO:0000250|UniProtKB:Q00756
ChainResidueDetails
ESER38
ESER42
FSER38
FSER42
GSER38
GSER42
HSER38
HSER42

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and ISPK => ECO:0000250|UniProtKB:Q00756
ChainResidueDetails
ESER46
BASN124
BHIS173
BHIS248
CASP64
CHIS66
CASP92
CASN124
CHIS173
CHIS248
DASP64
FSER46
DHIS66
DASP92
DASN124
DHIS173
DHIS248
GSER46
HSER46
AHIS173
AHIS248
BASP64
BHIS66
BASP92

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99MR9
ChainResidueDetails
ESER49
DSER2
DSER22
DSER325
FSER49
GSER49
HSER49
BSER22
BSER325
CSER2
CSER22
CSER325

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99MR9
ChainResidueDetails
ETHR56
FTHR56
GTHR56
HTHR56

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:Q00756
ChainResidueDetails
ESER65
FSER65
GSER65
HSER65

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ATHR320
BTHR320
CTHR320
DTHR320

218853

PDB entries from 2024-04-24

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