5ZOD

Crystal Structure of hFen1 in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 401

Chain	Residue
A	HOH504
A	HOH512
A	HOH513
A	HOH542
A	HOH547
A	HOH633

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	ASP233
A	TYR234
A	HOH542
A	GLU160
A	ASP179
A	ASP181

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 403

Chain	Residue
A	ALA17
A	ARG19
A	GLU206
A	HIS208
A	HOH544

---

site_id	AC4
Number of Residues	4
Details	binding site for residue K A 404

Chain	Residue
A	ASN219
A	GLN220
A	GLU221
A	HOH649

---

site_id	AC5
Number of Residues	5
Details	binding site for residue K A 405

Chain	Residue
A	ASP225
A	HIS276
A	HIS280
A	HOH506
A	HOH603

---

site_id	AC6
Number of Residues	5
Details	binding site for residue K A 406

Chain	Residue
A	LEU289
A	ASP290
A	PRO291
A	HOH594
A	HOH638

---

Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK

Chain	Residue	Details
A	ILE79-LYS93

---

site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GIPYLdAPsEAEASC

Chain	Residue	Details
A	GLY149-CYS163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK2","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---