5ZNR

Crystal structure of PtSHL in complex with an H3K27me3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0046872	molecular_function	metal ion binding
B	0003682	molecular_function	chromatin binding
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS142
A	CYS144
A	HIS165
A	CYS168

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS157
A	GLY159
A	CYS160
A	CYS184
A	CYS187

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 503

Chain	Residue
A	ARG60
P	THR32
P	GLY34

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 504

Chain	Residue
A	HIS104
A	SER105
A	ASN108

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 505

Chain	Residue
A	TYR148
A	MET154

---

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 A 506

Chain	Residue
A	ARG137

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS142
B	CYS144
B	HIS165
B	CYS168

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 502

Chain	Residue
B	CYS157
B	GLY159
B	CYS160
B	CYS184

---

site_id	AC9
Number of Residues	1
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG60

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 B 504

Chain	Residue
B	ARG75
B	GLN76

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 505

Chain	Residue
B	HIS104
B	SER105
B	ASN108

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 B 506

Chain	Residue
B	TYR148
B	ASP152
B	LEU153
B	MET154

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 B 507

Chain	Residue
B	TYR148
B	TRP163

---

Functional Information from PROSITE/UniProt

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CkCemPYnpddlmvqC

Chain	Residue	Details
A	CYS142-CYS157

---

site_id	PS01359
Number of Residues	46
Details	ZF_PHD_1 Zinc finger PHD-type signature. Ck.Cempynpddlm...................................VqCeg..Csdw.FHpaCiemsaeeakrldh................................FfCenC

Chain	Residue	Details
A	CYS142-CYS187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Not N6-acetylated => ECO:0000269|PubMed:15598823

Chain	Residue	Details
P	M3L27
P	LYS36
Q	M3L27
Q	LYS36

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Required for interaction with TSK => ECO:0000269|PubMed:35298257

Chain	Residue	Details
P	ALA31
Q	ALA31

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15598823

Chain	Residue	Details
P	LYS23
Q	LYS23

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:14712277, ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:17174094, ECO:0000269|PubMed:17439305, ECO:0000269|PubMed:19503079, ECO:0000269|PubMed:24626927, ECO:0000269|PubMed:35298257

Chain	Residue	Details
P	M3L27
Q	M3L27

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14610360, ECO:0000269|PubMed:15753571

Chain	Residue	Details
P	SER28
Q	SER28

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:16299497

Chain	Residue	Details
P	LYS36
Q	LYS36

---