Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5ZLP

Crystal structure of glutamine synthetase from helicobacter pylori

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006542	biological_process	glutamine biosynthetic process
A	0016020	cellular_component	membrane
A	0016874	molecular_function	ligase activity
A	0019740	biological_process	nitrogen utilization
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006542	biological_process	glutamine biosynthetic process
B	0016020	cellular_component	membrane
B	0016874	molecular_function	ligase activity
B	0019740	biological_process	nitrogen utilization
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006542	biological_process	glutamine biosynthetic process
C	0016020	cellular_component	membrane
C	0016874	molecular_function	ligase activity
C	0019740	biological_process	nitrogen utilization
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006542	biological_process	glutamine biosynthetic process
D	0016020	cellular_component	membrane
D	0016874	molecular_function	ligase activity
D	0019740	biological_process	nitrogen utilization
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006542	biological_process	glutamine biosynthetic process
E	0016020	cellular_component	membrane
E	0016874	molecular_function	ligase activity
E	0019740	biological_process	nitrogen utilization
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006542	biological_process	glutamine biosynthetic process
F	0016020	cellular_component	membrane
F	0016874	molecular_function	ligase activity
F	0019740	biological_process	nitrogen utilization
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006542	biological_process	glutamine biosynthetic process
G	0016020	cellular_component	membrane
G	0016874	molecular_function	ligase activity
G	0019740	biological_process	nitrogen utilization
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006542	biological_process	glutamine biosynthetic process
H	0016020	cellular_component	membrane
H	0016874	molecular_function	ligase activity
H	0019740	biological_process	nitrogen utilization
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006542	biological_process	glutamine biosynthetic process
I	0016020	cellular_component	membrane
I	0016874	molecular_function	ligase activity
I	0019740	biological_process	nitrogen utilization
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006542	biological_process	glutamine biosynthetic process
J	0016020	cellular_component	membrane
J	0016874	molecular_function	ligase activity
J	0019740	biological_process	nitrogen utilization
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0003824	molecular_function	catalytic activity
K	0004356	molecular_function	glutamine synthetase activity
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0006542	biological_process	glutamine biosynthetic process
K	0016020	cellular_component	membrane
K	0016874	molecular_function	ligase activity
K	0019740	biological_process	nitrogen utilization
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0003824	molecular_function	catalytic activity
L	0004356	molecular_function	glutamine synthetase activity
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0006542	biological_process	glutamine biosynthetic process
L	0016020	cellular_component	membrane
L	0016874	molecular_function	ligase activity
L	0019740	biological_process	nitrogen utilization
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ATP A 501

Chain	Residue
A	GLY137
A	HIS281
A	SER283
A	ARG349
A	ASN362
A	SER363
A	ARG365
A	HOH603
F	TYR43
F	PRO58
A	GLU139
A	TYR190
A	VAL219
A	HIS221
A	GLU230
A	VAL233
A	LYS234
A	PHE235

site_id	AC2
Number of Residues	15
Details	binding site for residue ATP B 501

Chain	Residue
B	GLY137
B	ALA138
B	GLU139
B	PHE218
B	VAL233
B	LYS234
B	PHE235
B	HIS281
B	SER283
B	ARG349
B	ARG354
B	ASN362
B	SER363
B	ARG365
B	GLU367

site_id	AC3
Number of Residues	14
Details	binding site for residue ATP C 501

Chain	Residue
C	GLY137
C	GLU139
C	PHE218
C	VAL233
C	PHE235
C	HIS279
C	HIS281
C	SER283
C	ARG349
C	ARG354
C	ASN362
C	SER363
C	ARG365
C	GLU367

site_id	AC4
Number of Residues	9
Details	binding site for residue ADP D 501

Chain	Residue
D	GLU139
D	PHE218
D	VAL233
D	PHE235
D	HIS281
D	SER283
D	ARG354
D	ASN362
D	ARG365

site_id	AC5
Number of Residues	12
Details	binding site for residue ADP E 501

Chain	Residue
E	GLU139
E	PHE218
E	VAL233
E	LYS234
E	PHE235
E	HIS281
E	SER283
E	ARG354
E	ASN362
E	ARG365
E	HOH607
E	HOH612

site_id	AC6
Number of Residues	13
Details	binding site for residue ATP F 501

Chain	Residue
E	PHE59
F	GLU139
F	PHE218
F	VAL233
F	PHE235
F	HIS281
F	SER283
F	ARG349
F	ARG354
F	ASN362
F	SER363
F	ARG365
F	GLU367

site_id	AC7
Number of Residues	15
Details	binding site for residue ADP H 501

Chain	Residue
H	TYR135
H	GLY137
H	GLU139
H	PHE218
H	GLU230
H	VAL233
H	LYS234
H	PHE235
H	HIS281
H	SER283
H	ARG349
H	ARG354
H	ASN362
H	ARG365
H	GLU367

site_id	AC8
Number of Residues	11
Details	binding site for residue ADP J 501

Chain	Residue
J	VAL233
J	PHE235
J	HIS281
J	SER283
J	ARG354
J	PRO356
J	ASN362
J	ARG365
J	TYR135
J	GLU139
J	PHE218

site_id	AC9
Number of Residues	13
Details	binding site for residue PPQ J 502

Chain	Residue
I	ASP60
J	GLU141
J	GLU223
J	ASN274
J	GLY275
J	HIS279
J	ARG331
J	TYR336
J	GLU337
J	ALA338
J	ARG349
J	ARG369
J	MG503

site_id	AD1
Number of Residues	4
Details	binding site for residue MG J 503

Chain	Residue
J	GLU141
J	GLU223
J	GLU230
J	PPQ502

site_id	AD2
Number of Residues	15
Details	binding site for residue ATP K 501

Chain	Residue
K	TYR135
K	GLY137
K	GLU139
K	PHE218
K	VAL233
K	LYS234
K	PHE235
K	HIS281
K	SER283
K	ARG354
K	ASN362
K	SER363
K	PPQ502
K	HOH604
K	HOH607

site_id	AD3
Number of Residues	14
Details	binding site for residue PPQ K 502

Chain	Residue
J	ASP60
K	GLU141
K	GLU223
K	ASN274
K	GLY275
K	GLY277
K	HIS279
K	ARG331
K	TYR336
K	GLU337
K	ARG349
K	ARG369
K	ATP501
K	HOH604

site_id	AD4
Number of Residues	16
Details	binding site for residue P3P L 501

Chain	Residue
K	ASP60
L	GLU139
L	GLU141
L	GLU223
L	GLU230
L	GLY275
L	GLY277
L	HIS279
L	ARG331
L	GLU337
L	ARG349
L	GLU367
L	ARG369
L	MG502
L	ADP503
L	MG504

site_id	AD5
Number of Residues	4
Details	binding site for residue MG L 502

Chain	Residue
L	GLU141
L	GLU223
L	GLU230
L	P3P501

site_id	AD6
Number of Residues	16
Details	binding site for residue ADP L 503

Chain	Residue
L	TYR135
L	GLY137
L	GLU139
L	PHE218
L	VAL233
L	PHE235
L	HIS281
L	SER283
L	TRP285
L	ASN290
L	ARG354
L	ASN362
L	ARG365
L	GLU367
L	P3P501
L	MG504

site_id	AD7
Number of Residues	4
Details	binding site for residue MG L 504

Chain	Residue
L	HIS221
L	GLU230
L	P3P501
L	ADP503

site_id	AD8
Number of Residues	16
Details	binding site for residue ATP G 501

Chain	Residue
G	TYR135
G	GLY137
G	GLU139
G	PHE218
G	VAL233
G	LYS234
G	PHE235
G	HIS281
G	SER283
G	TRP285
G	ARG349
G	ARG354
G	ASN362
G	ARG365
G	GLU367
G	HOH622

site_id	AD9
Number of Residues	11
Details	binding site for residue ADP I 501

Chain	Residue
I	GLY137
I	GLU139
I	PHE218
I	VAL233
I	LYS234
I	PHE235
I	HIS281
I	SER283
I	ARG354
I	ASN362
I	ARG365

site_id	AE1
Number of Residues	12
Details	binding site for residue PPQ I 502

Chain	Residue
H	ASP60
I	GLU141
I	GLU223
I	GLU230
I	ASN274
I	GLY275
I	HIS279
I	ARG331
I	GLU337
I	ARG349
I	ARG369
I	MG503

site_id	AE2
Number of Residues	4
Details	binding site for residue MG I 503

Chain	Residue
I	GLU141
I	GLU223
I	GLU230
I	PPQ502

Functional Information from PROSITE/UniProt

site_id	PS00181
Number of Residues	16
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLygd..NGSGmHthvS

Chain	Residue	Details
A	LYS268-SER283

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1008
Details	Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4404
Details	Domain: {"description":"GS catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01331","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A1P6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P12425","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P77961","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)