5ZLP
Crystal structure of glutamine synthetase from helicobacter pylori
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004356 | molecular_function | glutamine synthetase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006542 | biological_process | glutamine biosynthetic process |
| A | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019740 | biological_process | nitrogen utilization |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004356 | molecular_function | glutamine synthetase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006542 | biological_process | glutamine biosynthetic process |
| B | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019740 | biological_process | nitrogen utilization |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004356 | molecular_function | glutamine synthetase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006542 | biological_process | glutamine biosynthetic process |
| C | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019740 | biological_process | nitrogen utilization |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004356 | molecular_function | glutamine synthetase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006542 | biological_process | glutamine biosynthetic process |
| D | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016874 | molecular_function | ligase activity |
| D | 0019740 | biological_process | nitrogen utilization |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004356 | molecular_function | glutamine synthetase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006542 | biological_process | glutamine biosynthetic process |
| E | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016874 | molecular_function | ligase activity |
| E | 0019740 | biological_process | nitrogen utilization |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004356 | molecular_function | glutamine synthetase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006542 | biological_process | glutamine biosynthetic process |
| F | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016874 | molecular_function | ligase activity |
| F | 0019740 | biological_process | nitrogen utilization |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004356 | molecular_function | glutamine synthetase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006542 | biological_process | glutamine biosynthetic process |
| G | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| G | 0016020 | cellular_component | membrane |
| G | 0016874 | molecular_function | ligase activity |
| G | 0019740 | biological_process | nitrogen utilization |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004356 | molecular_function | glutamine synthetase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006542 | biological_process | glutamine biosynthetic process |
| H | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| H | 0016020 | cellular_component | membrane |
| H | 0016874 | molecular_function | ligase activity |
| H | 0019740 | biological_process | nitrogen utilization |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004356 | molecular_function | glutamine synthetase activity |
| I | 0005524 | molecular_function | ATP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006542 | biological_process | glutamine biosynthetic process |
| I | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| I | 0016020 | cellular_component | membrane |
| I | 0016874 | molecular_function | ligase activity |
| I | 0019740 | biological_process | nitrogen utilization |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004356 | molecular_function | glutamine synthetase activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006542 | biological_process | glutamine biosynthetic process |
| J | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| J | 0016020 | cellular_component | membrane |
| J | 0016874 | molecular_function | ligase activity |
| J | 0019740 | biological_process | nitrogen utilization |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0004356 | molecular_function | glutamine synthetase activity |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006542 | biological_process | glutamine biosynthetic process |
| K | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| K | 0016020 | cellular_component | membrane |
| K | 0016874 | molecular_function | ligase activity |
| K | 0019740 | biological_process | nitrogen utilization |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0004356 | molecular_function | glutamine synthetase activity |
| L | 0005524 | molecular_function | ATP binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006542 | biological_process | glutamine biosynthetic process |
| L | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| L | 0016020 | cellular_component | membrane |
| L | 0016874 | molecular_function | ligase activity |
| L | 0019740 | biological_process | nitrogen utilization |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue ATP A 501 |
| Chain | Residue |
| A | GLY137 |
| A | HIS281 |
| A | SER283 |
| A | ARG349 |
| A | ASN362 |
| A | SER363 |
| A | ARG365 |
| A | HOH603 |
| F | TYR43 |
| F | PRO58 |
| A | GLU139 |
| A | TYR190 |
| A | VAL219 |
| A | HIS221 |
| A | GLU230 |
| A | VAL233 |
| A | LYS234 |
| A | PHE235 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue ATP B 501 |
| Chain | Residue |
| B | GLY137 |
| B | ALA138 |
| B | GLU139 |
| B | PHE218 |
| B | VAL233 |
| B | LYS234 |
| B | PHE235 |
| B | HIS281 |
| B | SER283 |
| B | ARG349 |
| B | ARG354 |
| B | ASN362 |
| B | SER363 |
| B | ARG365 |
| B | GLU367 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ATP C 501 |
| Chain | Residue |
| C | GLY137 |
| C | GLU139 |
| C | PHE218 |
| C | VAL233 |
| C | PHE235 |
| C | HIS279 |
| C | HIS281 |
| C | SER283 |
| C | ARG349 |
| C | ARG354 |
| C | ASN362 |
| C | SER363 |
| C | ARG365 |
| C | GLU367 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue ADP D 501 |
| Chain | Residue |
| D | GLU139 |
| D | PHE218 |
| D | VAL233 |
| D | PHE235 |
| D | HIS281 |
| D | SER283 |
| D | ARG354 |
| D | ASN362 |
| D | ARG365 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue ADP E 501 |
| Chain | Residue |
| E | GLU139 |
| E | PHE218 |
| E | VAL233 |
| E | LYS234 |
| E | PHE235 |
| E | HIS281 |
| E | SER283 |
| E | ARG354 |
| E | ASN362 |
| E | ARG365 |
| E | HOH607 |
| E | HOH612 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue ATP F 501 |
| Chain | Residue |
| E | PHE59 |
| F | GLU139 |
| F | PHE218 |
| F | VAL233 |
| F | PHE235 |
| F | HIS281 |
| F | SER283 |
| F | ARG349 |
| F | ARG354 |
| F | ASN362 |
| F | SER363 |
| F | ARG365 |
| F | GLU367 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue ADP H 501 |
| Chain | Residue |
| H | TYR135 |
| H | GLY137 |
| H | GLU139 |
| H | PHE218 |
| H | GLU230 |
| H | VAL233 |
| H | LYS234 |
| H | PHE235 |
| H | HIS281 |
| H | SER283 |
| H | ARG349 |
| H | ARG354 |
| H | ASN362 |
| H | ARG365 |
| H | GLU367 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue ADP J 501 |
| Chain | Residue |
| J | VAL233 |
| J | PHE235 |
| J | HIS281 |
| J | SER283 |
| J | ARG354 |
| J | PRO356 |
| J | ASN362 |
| J | ARG365 |
| J | TYR135 |
| J | GLU139 |
| J | PHE218 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue PPQ J 502 |
| Chain | Residue |
| I | ASP60 |
| J | GLU141 |
| J | GLU223 |
| J | ASN274 |
| J | GLY275 |
| J | HIS279 |
| J | ARG331 |
| J | TYR336 |
| J | GLU337 |
| J | ALA338 |
| J | ARG349 |
| J | ARG369 |
| J | MG503 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG J 503 |
| Chain | Residue |
| J | GLU141 |
| J | GLU223 |
| J | GLU230 |
| J | PPQ502 |
| site_id | AD2 |
| Number of Residues | 15 |
| Details | binding site for residue ATP K 501 |
| Chain | Residue |
| K | TYR135 |
| K | GLY137 |
| K | GLU139 |
| K | PHE218 |
| K | VAL233 |
| K | LYS234 |
| K | PHE235 |
| K | HIS281 |
| K | SER283 |
| K | ARG354 |
| K | ASN362 |
| K | SER363 |
| K | PPQ502 |
| K | HOH604 |
| K | HOH607 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue PPQ K 502 |
| Chain | Residue |
| J | ASP60 |
| K | GLU141 |
| K | GLU223 |
| K | ASN274 |
| K | GLY275 |
| K | GLY277 |
| K | HIS279 |
| K | ARG331 |
| K | TYR336 |
| K | GLU337 |
| K | ARG349 |
| K | ARG369 |
| K | ATP501 |
| K | HOH604 |
| site_id | AD4 |
| Number of Residues | 16 |
| Details | binding site for residue P3P L 501 |
| Chain | Residue |
| K | ASP60 |
| L | GLU139 |
| L | GLU141 |
| L | GLU223 |
| L | GLU230 |
| L | GLY275 |
| L | GLY277 |
| L | HIS279 |
| L | ARG331 |
| L | GLU337 |
| L | ARG349 |
| L | GLU367 |
| L | ARG369 |
| L | MG502 |
| L | ADP503 |
| L | MG504 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG L 502 |
| Chain | Residue |
| L | GLU141 |
| L | GLU223 |
| L | GLU230 |
| L | P3P501 |
| site_id | AD6 |
| Number of Residues | 16 |
| Details | binding site for residue ADP L 503 |
| Chain | Residue |
| L | TYR135 |
| L | GLY137 |
| L | GLU139 |
| L | PHE218 |
| L | VAL233 |
| L | PHE235 |
| L | HIS281 |
| L | SER283 |
| L | TRP285 |
| L | ASN290 |
| L | ARG354 |
| L | ASN362 |
| L | ARG365 |
| L | GLU367 |
| L | P3P501 |
| L | MG504 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue MG L 504 |
| Chain | Residue |
| L | HIS221 |
| L | GLU230 |
| L | P3P501 |
| L | ADP503 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue ATP G 501 |
| Chain | Residue |
| G | TYR135 |
| G | GLY137 |
| G | GLU139 |
| G | PHE218 |
| G | VAL233 |
| G | LYS234 |
| G | PHE235 |
| G | HIS281 |
| G | SER283 |
| G | TRP285 |
| G | ARG349 |
| G | ARG354 |
| G | ASN362 |
| G | ARG365 |
| G | GLU367 |
| G | HOH622 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for residue ADP I 501 |
| Chain | Residue |
| I | GLY137 |
| I | GLU139 |
| I | PHE218 |
| I | VAL233 |
| I | LYS234 |
| I | PHE235 |
| I | HIS281 |
| I | SER283 |
| I | ARG354 |
| I | ASN362 |
| I | ARG365 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for residue PPQ I 502 |
| Chain | Residue |
| H | ASP60 |
| I | GLU141 |
| I | GLU223 |
| I | GLU230 |
| I | ASN274 |
| I | GLY275 |
| I | HIS279 |
| I | ARG331 |
| I | GLU337 |
| I | ARG349 |
| I | ARG369 |
| I | MG503 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue MG I 503 |
| Chain | Residue |
| I | GLU141 |
| I | GLU223 |
| I | GLU230 |
| I | PPQ502 |
Functional Information from PROSITE/UniProt
| site_id | PS00181 |
| Number of Residues | 16 |
| Details | GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPLygd..NGSGmHthvS |
| Chain | Residue | Details |
| A | LYS268-SER283 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WN39 |
| Chain | Residue | Details |
| B | HIS279 | |
| B | ARG349 | |
| B | ARG354 | |
| B | GLU367 | |
| C | GLU139 | |
| C | GLU141 | |
| C | GLU223 | |
| C | GLU230 | |
| C | HIS279 | |
| C | ARG349 | |
| C | ARG354 | |
| C | GLU367 | |
| D | GLU139 | |
| D | GLU141 | |
| D | GLU223 | |
| D | GLU230 | |
| D | HIS279 | |
| D | ARG349 | |
| D | ARG354 | |
| D | GLU367 | |
| E | GLU139 | |
| E | GLU141 | |
| E | GLU223 | |
| E | GLU230 | |
| E | HIS279 | |
| E | ARG349 | |
| E | ARG354 | |
| E | GLU367 | |
| F | GLU139 | |
| F | GLU141 | |
| F | GLU223 | |
| F | GLU230 | |
| F | HIS279 | |
| F | ARG349 | |
| F | ARG354 | |
| F | GLU367 | |
| H | GLU139 | |
| H | GLU141 | |
| H | GLU223 | |
| H | GLU230 | |
| H | HIS279 | |
| H | ARG349 | |
| H | ARG354 | |
| H | GLU367 | |
| J | GLU139 | |
| J | GLU141 | |
| J | GLU223 | |
| J | GLU230 | |
| J | HIS279 | |
| J | ARG349 | |
| J | ARG354 | |
| J | GLU367 | |
| K | GLU139 | |
| K | GLU141 | |
| K | GLU223 | |
| K | GLU230 | |
| K | HIS279 | |
| K | ARG349 | |
| K | ARG354 | |
| K | GLU367 | |
| L | GLU139 | |
| L | GLU141 | |
| L | GLU223 | |
| L | GLU230 | |
| L | HIS279 | |
| L | ARG349 | |
| L | ARG354 | |
| L | GLU367 | |
| G | GLU139 | |
| G | GLU141 | |
| G | GLU223 | |
| G | GLU230 | |
| G | HIS279 | |
| G | ARG349 | |
| G | ARG354 | |
| G | GLU367 | |
| I | GLU139 | |
| I | GLU141 | |
| I | GLU223 | |
| I | GLU230 | |
| I | HIS279 | |
| I | ARG349 | |
| I | ARG354 | |
| I | GLU367 | |
| A | GLU139 | |
| A | GLU141 | |
| A | GLU223 | |
| A | GLU230 | |
| A | HIS279 | |
| A | ARG354 | |
| A | GLU367 | |
| B | GLU139 | |
| B | GLU141 | |
| B | GLU223 | |
| B | GLU230 | |
| A | ARG349 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A1P6 |
| Chain | Residue | Details |
| E | ARG369 | |
| F | ASN274 | |
| F | HIS281 | |
| F | ARG331 | |
| F | GLU337 | |
| F | ARG369 | |
| H | ASN274 | |
| H | HIS281 | |
| H | ARG331 | |
| H | GLU337 | |
| H | ARG369 | |
| J | ASN274 | |
| J | HIS281 | |
| J | ARG331 | |
| J | GLU337 | |
| J | ARG369 | |
| K | ASN274 | |
| K | HIS281 | |
| K | ARG331 | |
| K | GLU337 | |
| K | ARG369 | |
| L | ASN274 | |
| L | HIS281 | |
| L | ARG331 | |
| L | GLU337 | |
| L | ARG369 | |
| G | ASN274 | |
| G | HIS281 | |
| G | ARG331 | |
| G | GLU337 | |
| G | ARG369 | |
| I | ASN274 | |
| I | HIS281 | |
| I | ARG331 | |
| I | GLU337 | |
| I | ARG369 | |
| A | ASN274 | |
| A | HIS281 | |
| A | ARG331 | |
| A | GLU337 | |
| A | ARG369 | |
| B | ASN274 | |
| B | HIS281 | |
| B | ARG331 | |
| B | GLU337 | |
| B | ARG369 | |
| C | ASN274 | |
| C | HIS281 | |
| C | ARG331 | |
| C | GLU337 | |
| C | ARG369 | |
| D | ASN274 | |
| D | HIS281 | |
| D | ARG331 | |
| D | GLU337 | |
| D | ARG369 | |
| E | ASN274 | |
| E | HIS281 | |
| E | ARG331 | |
| E | GLU337 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P12425 |
| Chain | Residue | Details |
| A | GLY275 | |
| B | GLY275 | |
| C | GLY275 | |
| D | GLY275 | |
| E | GLY275 | |
| F | GLY275 | |
| H | GLY275 | |
| J | GLY275 | |
| K | GLY275 | |
| L | GLY275 | |
| G | GLY275 | |
| I | GLY275 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P77961 |
| Chain | Residue | Details |
| A | SER283 | |
| B | SER283 | |
| C | SER283 | |
| D | SER283 | |
| E | SER283 | |
| F | SER283 | |
| H | SER283 | |
| J | SER283 | |
| K | SER283 | |
| L | SER283 | |
| G | SER283 | |
| I | SER283 |
