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5ZK9

Stapled-peptides tailored against initiation of translation

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue MGP A 1001
ChainResidue
ALYS54
AHOH1104
AHOH1118
AHOH1126
AHOH1131
AHOH1136
AHOH1154
AHOH1197
ATHR55
ATRP56
AMET101
ATRP102
AGLU103
AARG157
ALYS162
AHOH1102

site_idAC2
Number of Residues5
Detailsbinding site for residue PEG A 1002
ChainResidue
ATHR116
AGLN121
AVAL194
AILE195
AHOH1117

site_idAC3
Number of Residues9
Detailsbinding site for residue PEG A 1003
ChainResidue
AGLN40
AASN41
AASN118
AGLN121
ASER124
AASP147
AHOH1151
AHOH1164
BARG2

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL A 1004
ChainResidue
AARG42
AASP96
ALYS119
AGLN120
AARG122
AARG123
AHOH1113
AHOH1123

site_idAC5
Number of Residues8
Detailsbinding site for residues MK8 B 8 and MK8 B 12
ChainResidue
BSER6
BARG7
BGLN9
BLEU10
BLEU11
BLEU13
BLYS14
BNH215

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312
ChainResidueDetails
ATRP56
ATRP102
AARG157
ATHR205

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417
ChainResidueDetails
ALYS159

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323
ChainResidueDetails
ASER209

226707

PDB entries from 2024-10-30

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