Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5ZJE

LDHA-mla

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0006096	biological_process	glycolytic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
A	1990204	cellular_component	oxidoreductase complex
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006089	biological_process	lactate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0006096	biological_process	glycolytic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0070062	cellular_component	extracellular exosome
B	1990204	cellular_component	oxidoreductase complex
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006089	biological_process	lactate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0006096	biological_process	glycolytic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0042802	molecular_function	identical protein binding
C	0045296	molecular_function	cadherin binding
C	0070062	cellular_component	extracellular exosome
C	1990204	cellular_component	oxidoreductase complex
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006089	biological_process	lactate metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0006096	biological_process	glycolytic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0042802	molecular_function	identical protein binding
D	0045296	molecular_function	cadherin binding
D	0070062	cellular_component	extracellular exosome
D	1990204	cellular_component	oxidoreductase complex
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006089	biological_process	lactate metabolic process
E	0006090	biological_process	pyruvate metabolic process
E	0006096	biological_process	glycolytic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
E	0042802	molecular_function	identical protein binding
E	0045296	molecular_function	cadherin binding
E	0070062	cellular_component	extracellular exosome
E	1990204	cellular_component	oxidoreductase complex
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006089	biological_process	lactate metabolic process
F	0006090	biological_process	pyruvate metabolic process
F	0006096	biological_process	glycolytic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
F	0042802	molecular_function	identical protein binding
F	0045296	molecular_function	cadherin binding
F	0070062	cellular_component	extracellular exosome
F	1990204	cellular_component	oxidoreductase complex
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006089	biological_process	lactate metabolic process
G	0006090	biological_process	pyruvate metabolic process
G	0006096	biological_process	glycolytic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
G	0042802	molecular_function	identical protein binding
G	0045296	molecular_function	cadherin binding
G	0070062	cellular_component	extracellular exosome
G	1990204	cellular_component	oxidoreductase complex
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006089	biological_process	lactate metabolic process
H	0006090	biological_process	pyruvate metabolic process
H	0006096	biological_process	glycolytic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
H	0042802	molecular_function	identical protein binding
H	0045296	molecular_function	cadherin binding
H	0070062	cellular_component	extracellular exosome
H	1990204	cellular_component	oxidoreductase complex
I	0003824	molecular_function	catalytic activity
I	0004459	molecular_function	L-lactate dehydrogenase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0006089	biological_process	lactate metabolic process
I	0006090	biological_process	pyruvate metabolic process
I	0006096	biological_process	glycolytic process
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0019752	biological_process	carboxylic acid metabolic process
I	0042802	molecular_function	identical protein binding
I	0045296	molecular_function	cadherin binding
I	0070062	cellular_component	extracellular exosome
I	1990204	cellular_component	oxidoreductase complex
J	0003824	molecular_function	catalytic activity
J	0004459	molecular_function	L-lactate dehydrogenase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006089	biological_process	lactate metabolic process
J	0006090	biological_process	pyruvate metabolic process
J	0006096	biological_process	glycolytic process
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0019752	biological_process	carboxylic acid metabolic process
J	0042802	molecular_function	identical protein binding
J	0045296	molecular_function	cadherin binding
J	0070062	cellular_component	extracellular exosome
J	1990204	cellular_component	oxidoreductase complex
K	0003824	molecular_function	catalytic activity
K	0004459	molecular_function	L-lactate dehydrogenase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0006089	biological_process	lactate metabolic process
K	0006090	biological_process	pyruvate metabolic process
K	0006096	biological_process	glycolytic process
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0019752	biological_process	carboxylic acid metabolic process
K	0042802	molecular_function	identical protein binding
K	0045296	molecular_function	cadherin binding
K	0070062	cellular_component	extracellular exosome
K	1990204	cellular_component	oxidoreductase complex
L	0003824	molecular_function	catalytic activity
L	0004459	molecular_function	L-lactate dehydrogenase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0006089	biological_process	lactate metabolic process
L	0006090	biological_process	pyruvate metabolic process
L	0006096	biological_process	glycolytic process
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0019752	biological_process	carboxylic acid metabolic process
L	0042802	molecular_function	identical protein binding
L	0045296	molecular_function	cadherin binding
L	0070062	cellular_component	extracellular exosome
L	1990204	cellular_component	oxidoreductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue MLI A 601

Chain	Residue
A	ARG98
A	HOH703
A	HOH719
A	GLN99
A	ARG105
A	ASN137
A	LEU164
A	ARG168
A	HIS192
A	ALA237
A	THR247

site_id	AC2
Number of Residues	7
Details	binding site for residue MLI D 601

Chain	Residue
D	ARG105
D	ASN137
D	ARG168
D	HIS192
D	ALA237
D	THR247
D	ILE251

site_id	AC3
Number of Residues	8
Details	binding site for residue MLI E 601

Chain	Residue
E	GLN99
E	ARG105
E	ASN137
E	LEU164
E	ARG168
E	HIS192
E	ALA237
E	THR247

site_id	AC4
Number of Residues	8
Details	binding site for residue MLI G 601

Chain	Residue
G	GLN99
G	ARG105
G	ASN137
G	LEU164
G	ARG168
G	HIS192
G	ALA237
G	THR247

site_id	AC5
Number of Residues	7
Details	binding site for residue MLI J 601

Chain	Residue
J	ARG105
J	ASN137
J	LEU164
J	ARG168
J	HIS192
J	ALA237
J	THR247

site_id	AC6
Number of Residues	7
Details	binding site for residue MLI K 601

Chain	Residue
K	GLN99
K	ARG105
K	ASN137
K	LEU164
K	ARG168
K	HIS192
K	THR247

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. LGEHGDS

Chain	Residue	Details
A	LEU189-SER195

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	HIS192
J	HIS192
K	HIS192
L	HIS192
B	HIS192
C	HIS192
D	HIS192
E	HIS192
F	HIS192
G	HIS192
H	HIS192
I	HIS192

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:11276087

Chain	Residue	Details
A	GLY28
E	ARG98
F	GLY28
F	ARG98
G	GLY28
G	ARG98
H	GLY28
H	ARG98
I	GLY28
I	ARG98
J	GLY28
A	ARG98
J	ARG98
K	GLY28
K	ARG98
L	GLY28
L	ARG98
B	GLY28
B	ARG98
C	GLY28
C	ARG98
D	GLY28
D	ARG98
E	GLY28

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING:

Chain	Residue	Details
A	ARG105
C	ASN137
C	ARG168
C	THR247
D	ARG105
D	ASN137
D	ARG168
D	THR247
E	ARG105
E	ASN137
E	ARG168
A	ASN137
E	THR247
F	ARG105
F	ASN137
F	ARG168
F	THR247
G	ARG105
G	ASN137
G	ARG168
G	THR247
H	ARG105
A	ARG168
H	ASN137
H	ARG168
H	THR247
I	ARG105
I	ASN137
I	ARG168
I	THR247
J	ARG105
J	ASN137
J	ARG168
A	THR247
J	THR247
K	ARG105
K	ASN137
K	ARG168
K	THR247
L	ARG105
L	ASN137
L	ARG168
L	THR247
B	ARG105
B	ASN137
B	ARG168
B	THR247
C	ARG105

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.10, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895

Chain	Residue	Details
A	ALA1
J	ALA1
K	ALA1
L	ALA1
B	ALA1
C	ALA1
D	ALA1
E	ALA1
F	ALA1
G	ALA1
H	ALA1
I	ALA1

site_id	SWS_FT_FI5
Number of Residues	36
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	LYS4
D	LYS4
D	LYS117
D	LYS317
E	LYS4
E	LYS117
E	LYS317
F	LYS4
F	LYS117
F	LYS317
G	LYS4
A	LYS117
G	LYS117
G	LYS317
H	LYS4
H	LYS117
H	LYS317
I	LYS4
I	LYS117
I	LYS317
J	LYS4
J	LYS117
A	LYS317
J	LYS317
K	LYS4
K	LYS117
K	LYS317
L	LYS4
L	LYS117
L	LYS317
B	LYS4
B	LYS117
B	LYS317
C	LYS4
C	LYS117
C	LYS317

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
A	TYR9
J	TYR9
K	TYR9
L	TYR9
B	TYR9
C	TYR9
D	TYR9
E	TYR9
F	TYR9
G	TYR9
H	TYR9
I	TYR9

site_id	SWS_FT_FI7
Number of Residues	36
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS13
D	LYS13
D	LYS80
D	LYS125
E	LYS13
E	LYS80
E	LYS125
F	LYS13
F	LYS80
F	LYS125
G	LYS13
A	LYS80
G	LYS80
G	LYS125
H	LYS13
H	LYS80
H	LYS125
I	LYS13
I	LYS80
I	LYS125
J	LYS13
J	LYS80
A	LYS125
J	LYS125
K	LYS13
K	LYS80
K	LYS125
L	LYS13
L	LYS80
L	LYS125
B	LYS13
B	LYS80
B	LYS125
C	LYS13
C	LYS80
C	LYS125

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR17
J	THR17
K	THR17
L	THR17
B	THR17
C	THR17
D	THR17
E	THR17
F	THR17
G	THR17
H	THR17
I	THR17

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS56
J	LYS56
K	LYS56
L	LYS56
B	LYS56
C	LYS56
D	LYS56
E	LYS56
F	LYS56
G	LYS56
H	LYS56
I	LYS56

site_id	SWS_FT_FI10
Number of Residues	36
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	LYS223
D	LYS223
D	LYS231
D	LYS242
E	LYS223
E	LYS231
E	LYS242
F	LYS223
F	LYS231
F	LYS242
G	LYS223
A	LYS231
G	LYS231
G	LYS242
H	LYS223
H	LYS231
H	LYS242
I	LYS223
I	LYS231
I	LYS242
J	LYS223
J	LYS231
A	LYS242
J	LYS242
K	LYS223
K	LYS231
K	LYS242
L	LYS223
L	LYS231
L	LYS242
B	LYS223
B	LYS231
B	LYS242
C	LYS223
C	LYS231
C	LYS242

site_id	SWS_FT_FI11
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P06151

Chain	Residue	Details
A	TYR238
J	TYR238
K	TYR238
L	TYR238
B	TYR238
C	TYR238
D	TYR238
E	TYR238
F	TYR238
G	TYR238
H	TYR238
I	TYR238

site_id	SWS_FT_FI12
Number of Residues	24
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P04642

Chain	Residue	Details
A	THR308
E	THR321
F	THR308
F	THR321
G	THR308
G	THR321
H	THR308
H	THR321
I	THR308
I	THR321
J	THR308
A	THR321
J	THR321
K	THR308
K	THR321
L	THR308
L	THR321
B	THR308
B	THR321
C	THR308
C	THR321
D	THR308
D	THR321
E	THR308

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER309
J	SER309
K	SER309
L	SER309
B	SER309
C	SER309
D	SER309
E	SER309
F	SER309
G	SER309
H	SER309
I	SER309

site_id	SWS_FT_FI14
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS56
F	LYS56
G	LYS56
H	LYS56
I	LYS56
J	LYS56
K	LYS56
L	LYS56
B	LYS56
C	LYS56
D	LYS56
E	LYS56

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)