5ZI4
MDH3 wild type, nad-oaa-form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0006735 | biological_process | NADH regeneration |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0006735 | biological_process | NADH regeneration |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue OAA A 401 |
| Chain | Residue |
| A | ARG80 |
| A | ASN118 |
| A | ARG152 |
| A | HIS187 |
| A | GLY220 |
| A | ALA233 |
| A | NAD402 |
| A | HOH511 |
| A | HOH529 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | binding site for residue NAD A 402 |
| Chain | Residue |
| A | GLY8 |
| A | SER10 |
| A | GLY11 |
| A | GLY12 |
| A | VAL13 |
| A | TYR33 |
| A | ASP34 |
| A | ILE35 |
| A | PRO75 |
| A | ALA76 |
| A | GLY77 |
| A | VAL78 |
| A | PRO79 |
| A | ASN93 |
| A | ILE96 |
| A | LEU100 |
| A | ILE116 |
| A | ASN118 |
| A | VAL145 |
| A | HIS187 |
| A | ALA233 |
| A | MET237 |
| A | OAA401 |
| A | HOH508 |
| A | HOH509 |
| A | HOH511 |
| A | HOH516 |
| A | HOH524 |
| A | HOH535 |
| A | HOH539 |
| A | HOH549 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue OAA B 401 |
| Chain | Residue |
| B | ARG80 |
| B | ASN118 |
| B | ARG152 |
| B | HIS187 |
| B | GLY220 |
| B | ALA233 |
| B | NAD402 |
| B | HOH536 |
| B | HOH539 |
| B | HOH554 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | binding site for residue NAD B 402 |
| Chain | Residue |
| B | GLY8 |
| B | SER10 |
| B | GLY11 |
| B | GLY12 |
| B | VAL13 |
| B | TYR33 |
| B | ASP34 |
| B | ILE35 |
| B | PRO75 |
| B | ALA76 |
| B | GLY77 |
| B | VAL78 |
| B | PRO79 |
| B | ASN93 |
| B | LEU100 |
| B | ILE116 |
| B | ASN118 |
| B | VAL145 |
| B | HIS187 |
| B | ALA233 |
| B | THR234 |
| B | MET237 |
| B | OAA401 |
| B | HOH509 |
| B | HOH513 |
| B | HOH514 |
| B | HOH520 |
| B | HOH522 |
| B | HOH523 |
| B | HOH534 |
| B | HOH536 |
| B | HOH546 |
| B | HOH559 |
| B | HOH575 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. VTNLDlvRAetfL |
| Chain | Residue | Details |
| A | VAL145-LEU157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00346 |
| Chain | Residue | Details |
| A | HIS187 | |
| B | HIS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P40926 |
| Chain | Residue | Details |
| A | GLY8 | |
| B | MET237 | |
| A | ASP34 | |
| A | ASN93 | |
| A | ILE116 | |
| A | MET237 | |
| B | GLY8 | |
| B | ASP34 | |
| B | ASN93 | |
| B | ILE116 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10004 |
| Chain | Residue | Details |
| A | ARG80 | |
| A | ARG86 | |
| A | ASN118 | |
| A | ARG152 | |
| B | ARG80 | |
| B | ARG86 | |
| B | ASN118 | |
| B | ARG152 |
