Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | GLY165 |
| A | ARG166 |
| A | HIS198 |
| A | ARG199 |
| A | HOH502 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | HIS184 |
| B | ARG199 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | HIS198 |
| B | ARG199 |
| B | THR220 |
| B | LEU222 |
| B | HOH527 |
| B | HOH557 |
| B | HOH598 |
| B | GLY165 |
| B | ARG166 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | PRO274 |
| B | GLY275 |
| B | GLY276 |
| B | VAL277 |
| B | GLY278 |
| B | HOH610 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| A | ARG159 |
| B | ASP214 |
| B | LYS232 |
| B | HOH502 |
| B | HOH512 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| A | ALA208 |
| A | TYR209 |
| B | ASN212 |
| B | HOH572 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | THR156 |
| B | GLY189 |
| B | MET190 |
| B | LYS203 |
| B | HOH594 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeQLLseIqnLNeDnsvdgILVQLPV |
| Chain | Residue | Details |
| A | GLU75-VAL100 | |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO274-VAL282 | |
