5ZE9
Crystal structure of AMP-PNP bound mutant A3B3 complex from Enterococcus hirae V-ATPase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0006814 | biological_process | sodium ion transport |
A | 0035725 | biological_process | sodium ion transmembrane transport |
A | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
A | 0045259 | cellular_component | proton-transporting ATP synthase complex |
A | 0046034 | biological_process | ATP metabolic process |
A | 0046932 | molecular_function | sodium-transporting ATP synthase activity, rotational mechanism |
A | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
A | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
A | 0046962 | molecular_function | sodium-transporting ATPase activity, rotational mechanism |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0006814 | biological_process | sodium ion transport |
B | 0035725 | biological_process | sodium ion transmembrane transport |
B | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
B | 0045259 | cellular_component | proton-transporting ATP synthase complex |
B | 0046034 | biological_process | ATP metabolic process |
B | 0046932 | molecular_function | sodium-transporting ATP synthase activity, rotational mechanism |
B | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
B | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
B | 0046962 | molecular_function | sodium-transporting ATPase activity, rotational mechanism |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0006814 | biological_process | sodium ion transport |
C | 0035725 | biological_process | sodium ion transmembrane transport |
C | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
C | 0045259 | cellular_component | proton-transporting ATP synthase complex |
C | 0046034 | biological_process | ATP metabolic process |
C | 0046932 | molecular_function | sodium-transporting ATP synthase activity, rotational mechanism |
C | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
C | 0046961 | molecular_function | proton-transporting ATPase activity, rotational mechanism |
C | 0046962 | molecular_function | sodium-transporting ATPase activity, rotational mechanism |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0006814 | biological_process | sodium ion transport |
D | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
D | 0046034 | biological_process | ATP metabolic process |
D | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
D | 1902600 | biological_process | proton transmembrane transport |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0006814 | biological_process | sodium ion transport |
E | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
E | 0046034 | biological_process | ATP metabolic process |
E | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
E | 1902600 | biological_process | proton transmembrane transport |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0006814 | biological_process | sodium ion transport |
F | 0042777 | biological_process | proton motive force-driven plasma membrane ATP synthesis |
F | 0046034 | biological_process | ATP metabolic process |
F | 0046933 | molecular_function | proton-transporting ATP synthase activity, rotational mechanism |
F | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue ANP A 601 |
Chain | Residue |
A | PHE234 |
A | PHE425 |
A | ASN504 |
A | ALA505 |
A | PHE506 |
A | MG602 |
A | GOL605 |
A | HOH704 |
A | HOH711 |
A | HOH765 |
A | HOH766 |
A | GLY235 |
A | HOH783 |
A | HOH786 |
A | HOH809 |
A | HOH816 |
D | TYR321 |
D | ARG350 |
A | ALA236 |
A | GLY237 |
A | LYS238 |
A | THR239 |
A | VAL240 |
A | GLU261 |
A | ARG262 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 602 |
Chain | Residue |
A | THR239 |
A | ANP601 |
A | HOH704 |
A | HOH765 |
A | HOH783 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue GOL A 603 |
Chain | Residue |
A | GLN50 |
A | ARG194 |
A | GLU304 |
A | MET341 |
A | TYR357 |
A | ARG361 |
A | HOH759 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue GOL A 604 |
Chain | Residue |
A | TYR357 |
A | ARG361 |
A | HOH706 |
A | HOH747 |
A | HOH806 |
A | HOH845 |
E | GLY13 |
E | HOH706 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue GOL A 605 |
Chain | Residue |
A | ANP601 |
A | GOL607 |
A | HOH718 |
D | ARG350 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue GOL A 606 |
Chain | Residue |
A | LEU419 |
A | ASN429 |
A | TRP430 |
A | ILE431 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue GOL A 607 |
Chain | Residue |
A | HIS243 |
A | GLN244 |
A | LYS247 |
A | ALA505 |
A | PHE506 |
A | GOL605 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue GOL A 608 |
Chain | Residue |
A | ARG423 |
A | HOH716 |
A | HOH819 |
D | LEU138 |
D | ASN139 |
D | ASN370 |
D | PHE373 |
D | HOH619 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue GOL A 609 |
Chain | Residue |
A | PHE102 |
A | HOH701 |
A | HOH713 |
site_id | AD1 |
Number of Residues | 25 |
Details | binding site for residue ANP B 601 |
Chain | Residue |
B | GLY235 |
B | ALA236 |
B | GLY237 |
B | LYS238 |
B | THR239 |
B | VAL240 |
B | GLU261 |
B | ARG262 |
B | PHE425 |
B | ASN504 |
B | ALA505 |
B | PHE506 |
B | MG602 |
B | GOL610 |
B | HOH704 |
B | HOH731 |
B | HOH733 |
B | HOH746 |
B | HOH795 |
B | HOH834 |
B | HOH853 |
B | HOH921 |
E | TYR321 |
E | ARG350 |
E | LYS352 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MG B 602 |
Chain | Residue |
B | HOH795 |
B | THR239 |
B | ANP601 |
B | HOH731 |
B | HOH746 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue GOL B 603 |
Chain | Residue |
B | ASP416 |
B | SER418 |
B | LEU419 |
B | ASN429 |
B | TRP430 |
B | GLU468 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue GOL B 604 |
Chain | Residue |
B | GLN432 |
B | HOH705 |
B | HOH843 |
B | HOH855 |
F | ARG331 |
F | LYS335 |
site_id | AD5 |
Number of Residues | 7 |
Details | binding site for residue GOL B 605 |
Chain | Residue |
B | HIS243 |
B | GLN244 |
B | LYS247 |
B | ALA505 |
B | PHE506 |
B | GOL610 |
B | HOH814 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue GOL B 606 |
Chain | Residue |
B | ASN153 |
B | ARG195 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue GOL B 607 |
Chain | Residue |
B | GLY414 |
B | LEU415 |
B | ASP416 |
B | ASN429 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue GOL B 608 |
Chain | Residue |
B | PHE234 |
B | SER417 |
B | HOH702 |
B | HOH836 |
E | GLN326 |
E | LEU348 |
E | HOH632 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue GOL B 609 |
Chain | Residue |
B | GLU41 |
B | GLU347 |
B | TYR357 |
B | ARG361 |
B | HOH724 |
B | HOH748 |
B | HOH820 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue GOL B 610 |
Chain | Residue |
B | VAL240 |
B | PHE506 |
B | ANP601 |
B | GOL605 |
B | HOH703 |
E | ARG350 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue GOL B 611 |
Chain | Residue |
B | VAL270 |
B | ASN271 |
B | GLU275 |
E | LYS3 |
E | GLU4 |
E | TYR5 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue GOL B 612 |
Chain | Residue |
B | MET95 |
B | GLN99 |
B | SER100 |
B | ASN101 |
site_id | AE4 |
Number of Residues | 27 |
Details | binding site for residue ANP C 601 |
Chain | Residue |
C | PHE234 |
C | GLY235 |
C | ALA236 |
C | GLY237 |
C | LYS238 |
C | THR239 |
C | VAL240 |
C | GLU261 |
C | ARG262 |
C | PHE425 |
C | ASN504 |
C | ALA505 |
C | PHE506 |
C | MG602 |
C | HOH702 |
C | HOH708 |
C | HOH737 |
C | HOH750 |
C | HOH764 |
C | HOH787 |
C | HOH832 |
F | GLY320 |
F | TYR321 |
F | ARG350 |
F | LYS352 |
F | GOL507 |
F | HOH701 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue MG C 602 |
Chain | Residue |
C | THR239 |
C | ANP601 |
C | HOH737 |
C | HOH750 |
C | HOH764 |
site_id | AE6 |
Number of Residues | 5 |
Details | binding site for residue GOL C 603 |
Chain | Residue |
C | GLY414 |
C | LEU415 |
C | ASP416 |
C | ASN429 |
C | HOH728 |
site_id | AE7 |
Number of Residues | 6 |
Details | binding site for residue GOL C 604 |
Chain | Residue |
C | ASP416 |
C | SER418 |
C | LEU419 |
C | ASN429 |
C | TRP430 |
C | ILE431 |
site_id | AE8 |
Number of Residues | 6 |
Details | binding site for residue GOL C 606 |
Chain | Residue |
C | GLU54 |
C | HOH719 |
F | GLU27 |
F | ARG226 |
F | THR283 |
F | GOL501 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue GOL C 607 |
Chain | Residue |
C | ILE397 |
C | GLN403 |
C | LEU406 |
C | HOH717 |
C | HOH847 |
site_id | AF1 |
Number of Residues | 4 |
Details | binding site for residue GOL C 608 |
Chain | Residue |
C | HIS243 |
C | GLN244 |
C | LYS247 |
F | GOL507 |
site_id | AF2 |
Number of Residues | 5 |
Details | binding site for residue GOL C 609 |
Chain | Residue |
C | SER81 |
C | GLN82 |
C | MET83 |
C | ASP92 |
C | VAL270 |
site_id | AF3 |
Number of Residues | 6 |
Details | binding site for residue GOL C 610 |
Chain | Residue |
C | TRP248 |
C | LEU276 |
C | ASP278 |
C | GLU283 |
C | LEU285 |
C | HOH908 |
site_id | AF4 |
Number of Residues | 9 |
Details | binding site for residue MES D 501 |
Chain | Residue |
C | MET95 |
C | GLU96 |
C | GLN99 |
C | SER100 |
C | ASN101 |
D | TYR418 |
D | HOH647 |
F | ARG292 |
F | GLY293 |
site_id | AF5 |
Number of Residues | 5 |
Details | binding site for residue GOL D 502 |
Chain | Residue |
C | GLU96 |
C | VAL97 |
D | GLN339 |
D | ASN414 |
D | GLY416 |
site_id | AF6 |
Number of Residues | 4 |
Details | binding site for residue GOL D 503 |
Chain | Residue |
A | ASN297 |
D | ASN112 |
D | GLY113 |
D | THR283 |
site_id | AF7 |
Number of Residues | 4 |
Details | binding site for residue GOL D 504 |
Chain | Residue |
D | GLN371 |
D | GLU441 |
D | LYS443 |
D | ARG444 |
site_id | AF8 |
Number of Residues | 6 |
Details | binding site for residue GOL E 501 |
Chain | Residue |
B | ASN297 |
E | ASN112 |
E | GLY113 |
E | GLU114 |
E | THR283 |
E | ARG287 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue GOL E 502 |
Chain | Residue |
B | PHE102 |
E | TYR234 |
E | GLU238 |
E | HOH628 |
E | HOH641 |
site_id | AG1 |
Number of Residues | 6 |
Details | binding site for residue GOL E 503 |
Chain | Residue |
E | GLN78 |
E | LEU79 |
E | GLY80 |
E | LEU93 |
E | TYR108 |
E | HOH719 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue GOL E 504 |
Chain | Residue |
A | HOH748 |
A | HOH788 |
E | ARG331 |
E | HOH601 |
site_id | AG3 |
Number of Residues | 6 |
Details | binding site for residue GOL F 501 |
Chain | Residue |
C | GLU54 |
C | ASN297 |
C | GOL606 |
F | ASN112 |
F | THR283 |
F | ARG287 |
site_id | AG4 |
Number of Residues | 1 |
Details | binding site for residue GOL F 502 |
Chain | Residue |
F | THR361 |
site_id | AG5 |
Number of Residues | 5 |
Details | binding site for residue GOL F 503 |
Chain | Residue |
C | GLN447 |
F | GLY80 |
F | GLY94 |
F | ILE103 |
F | HOH616 |
site_id | AG6 |
Number of Residues | 3 |
Details | binding site for residue GOL F 504 |
Chain | Residue |
F | ASP176 |
F | ARG206 |
F | MET241 |
site_id | AG7 |
Number of Residues | 3 |
Details | binding site for residue GOL F 505 |
Chain | Residue |
D | GLN200 |
F | TYR237 |
F | HOH693 |
site_id | AG8 |
Number of Residues | 4 |
Details | binding site for residue GOL F 506 |
Chain | Residue |
F | ARG264 |
F | ARG265 |
F | HOH646 |
F | HOH681 |
site_id | AG9 |
Number of Residues | 7 |
Details | binding site for residue GOL F 507 |
Chain | Residue |
C | THR239 |
C | PHE506 |
C | ANP601 |
C | GOL608 |
C | HOH831 |
C | HOH867 |
F | ARG350 |
Functional Information from PROSITE/UniProt
site_id | PS00152 |
Number of Residues | 10 |
Details | ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPIDVLPSLS |
Chain | Residue | Details |
D | PRO340-SER349 | |
A | PRO426-SER435 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLY232 | |
B | GLY232 | |
C | GLY232 |