5ZBU
Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0036211 | biological_process | protein modification process |
| B | 0051865 | biological_process | protein autoubiquitination |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070936 | biological_process | protein K48-linked ubiquitination |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0036211 | biological_process | protein modification process |
| C | 0051865 | biological_process | protein autoubiquitination |
| C | 0061630 | molecular_function | ubiquitin protein ligase activity |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070936 | biological_process | protein K48-linked ubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | CYS240 |
| A | CYS243 |
| A | HIS263 |
| A | CYS266 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | CYS258 |
| A | HIS260 |
| A | CYS278 |
| A | CYS281 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 1001 |
| Chain | Residue |
| D | CYS243 |
| D | HIS263 |
| D | CYS266 |
| D | CYS240 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 1002 |
| Chain | Residue |
| D | CYS258 |
| D | HIS260 |
| D | CYS278 |
| D | CYS281 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 146 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 75 |
| Details | Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
