5ZB0
Crystal structure of thymidylate kinase in complex with ADP and TDP from thermus thermophilus HB8
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | binding site for residue TYD A 201 |
Chain | Residue |
A | ASP12 |
A | SER96 |
A | TYR99 |
A | GLN100 |
A | LEU147 |
A | HOH301 |
A | HOH315 |
A | HOH322 |
A | HOH331 |
A | HOH356 |
A | HOH364 |
A | ARG38 |
A | HOH395 |
A | HOH437 |
A | GLU39 |
A | PRO40 |
A | ARG48 |
A | PHE65 |
A | ARG69 |
A | ARG91 |
A | SER95 |
site_id | AC2 |
Number of Residues | 22 |
Details | binding site for residue ADP A 202 |
Chain | Residue |
A | LEU11 |
A | GLY13 |
A | SER14 |
A | GLY15 |
A | LYS16 |
A | THR17 |
A | THR18 |
A | GLN54 |
A | ALA178 |
A | LEU180 |
A | GLU182 |
A | MG204 |
A | HOH317 |
A | HOH319 |
A | HOH324 |
A | HOH331 |
A | HOH336 |
A | HOH341 |
A | HOH342 |
A | HOH354 |
A | HOH356 |
A | HOH366 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 203 |
Chain | Residue |
A | THR7 |
A | GLU9 |
A | TYR92 |
A | ASP94 |
A | HOH302 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue MG A 204 |
Chain | Residue |
A | THR17 |
A | ADP202 |
A | HOH315 |
A | HOH317 |
A | HOH331 |
A | HOH356 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MG A 205 |
Chain | Residue |
A | GLU39 |
A | PRO40 |
A | PHE65 |
A | ASP68 |
A | ARG69 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue MG A 206 |
Chain | Residue |
A | TYR62 |
A | SER66 |
A | ARG69 |
A | LEU93 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue CL A 207 |
Chain | Residue |
A | GLU169 |
A | PRO170 |
A | GLY171 |
A | ARG172 |
A | HOH456 |
B | HOH378 |
site_id | AC8 |
Number of Residues | 14 |
Details | binding site for residue TYD B 201 |
Chain | Residue |
A | HOH373 |
A | HOH454 |
B | ASP12 |
B | PRO40 |
B | ARG48 |
B | PHE65 |
B | ARG69 |
B | SER95 |
B | SER96 |
B | TYR99 |
B | GLN100 |
B | HOH310 |
B | HOH392 |
B | HOH415 |
site_id | AC9 |
Number of Residues | 22 |
Details | binding site for residue ADP B 202 |
Chain | Residue |
B | HOH320 |
B | HOH334 |
B | HOH346 |
B | HOH366 |
B | HOH377 |
B | HOH380 |
A | GLY105 |
A | HOH332 |
A | HOH398 |
B | LEU11 |
B | ASP12 |
B | GLY13 |
B | SER14 |
B | GLY15 |
B | LYS16 |
B | THR17 |
B | THR18 |
B | LEU138 |
B | LEU180 |
B | GLU182 |
B | MG206 |
B | HOH317 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MG B 203 |
Chain | Residue |
B | THR7 |
B | GLU9 |
B | TYR92 |
B | ASP94 |
B | HOH365 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue MG B 204 |
Chain | Residue |
B | PHE65 |
B | ASP68 |
B | ARG69 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue MG B 205 |
Chain | Residue |
B | TYR62 |
B | SER66 |
B | ARG69 |
B | LEU93 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue MG B 206 |
Chain | Residue |
B | THR17 |
B | ADP202 |
B | HOH317 |
B | HOH320 |
B | HOH334 |
B | HOH381 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ |
Chain | Residue | Details |
A | ILE88-GLN100 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
Chain | Residue | Details |
A | GLY10 | |
B | GLY10 |