5Z9N

S.aureus GyrB ATPase domain in complex with 4,6-dichloro-2-(methylthio)pyrimidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue HX5 A 301

Chain	Residue
A	ASN46
A	GLU50
A	VAL71
A	ASP73
A	VAL120
A	THR165
A	HOH405

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	SO4303
A	ALA152
A	ARG192

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
A	VAL88
A	GLU92
A	PRO150
A	GLU193
A	SO4302

---

site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG192

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 305

Chain	Residue
A	ASP31
A	ASN178

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor (ATPase activity)","evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8248233","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10734094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25202966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25849408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---