5Z9N

S.aureus GyrB ATPase domain in complex with 4,6-dichloro-2-(methylthio)pyrimidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue HX5 A 301

Chain	Residue
A	ASN46
A	GLU50
A	VAL71
A	ASP73
A	VAL120
A	THR165
A	HOH405

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	SO4303
A	ALA152
A	ARG192

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site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
A	VAL88
A	GLU92
A	PRO150
A	GLU193
A	SO4302

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site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG192

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site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 305

Chain	Residue
A	ASP31
A	ASN178

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor (ATPase activity) => ECO:0000305|PubMed:10734094, ECO:0000305|PubMed:8248233

Chain	Residue	Details
A	GLU42

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:10734094, ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408

Chain	Residue	Details
A	ASN46
A	ASP73
A	GLY102
A	TYR109
A	LEU115

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site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:25849408

Chain	Residue	Details
A	ILE94
A	VAL97
A	ALA100
A	LYS103
A	ASP105
A	GLY117
A	SER121

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