5Z98

Crystal Structure of the Primate APOBEC3H Dimer mediated by RNA Duplex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0010526	biological_process	transposable element silencing
A	0016787	molecular_function	hydrolase activity
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0010526	biological_process	transposable element silencing
B	0016787	molecular_function	hydrolase activity
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0045071	biological_process	negative regulation of viral genome replication
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 300

Chain	Residue
A	HIS54
A	CYS85
A	CYS88
A	HOH409

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site_id	AC2
Number of Residues	3
Details	binding site for residue ZN B 300

Chain	Residue
B	HIS54
B	CYS85
B	CYS88

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEicFIneiksmgldetqcyqvtcyltws..........PCss......CawkL

Chain	Residue	Details
A	HIS54-LEU92

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