5Z94
Crystal Structure of SIRT3 in complex with H3K4bhb peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS256 |
| A | CYS259 |
| A | CYS280 |
| A | CYS283 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | LEU298 |
| A | LEU303 |
| C | ARG2 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | GLN138 |
| A | ARG135 |
| A | ALA136 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | VAL277 |
| A | ARG279 |
| A | HOH506 |
| A | HOH515 |
| A | HOH537 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CIT A 405 |
| Chain | Residue |
| A | ARG224 |
| A | SER242 |
| A | ARG301 |
| A | LEU304 |
| A | HOH663 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS256 |
| B | CYS259 |
| B | CYS280 |
| B | CYS283 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | ARG135 |
| B | ALA136 |
| B | GLN138 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | VAL277 |
| B | ARG279 |
| B | HOH502 |
| B | HOH503 |
| B | HOH512 |
| B | HOH532 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue CIT B 404 |
| Chain | Residue |
| B | ARG224 |
| B | SER242 |
| B | ARG301 |
| B | LEU304 |
| B | HOH584 |
| B | HOH673 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 101 |
| Chain | Residue |
| B | LEU298 |
| D | ARG2 |
| D | HOH202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
