5Z3G

Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000027	biological_process	ribosomal large subunit assembly
a	0000464	biological_process	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
a	0000465	biological_process	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005730	cellular_component	nucleolus
a	0006364	biological_process	rRNA processing
a	0008097	molecular_function	5S rRNA binding
a	0019843	molecular_function	rRNA binding
a	0030687	cellular_component	preribosome, large subunit precursor
a	0042134	molecular_function	rRNA primary transcript binding
a	0042254	biological_process	ribosome biogenesis
b	0000280	biological_process	nuclear division
b	0003729	molecular_function	mRNA binding
b	0005515	molecular_function	protein binding
b	0005730	cellular_component	nucleolus
b	0006364	biological_process	rRNA processing
b	0030687	cellular_component	preribosome, large subunit precursor
b	0034399	cellular_component	nuclear periphery
b	0042254	biological_process	ribosome biogenesis
b	0042273	biological_process	ribosomal large subunit biogenesis
b	0042802	molecular_function	identical protein binding
c	0002181	biological_process	cytoplasmic translation
c	0003723	molecular_function	RNA binding
c	0003735	molecular_function	structural constituent of ribosome
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
c	0015934	cellular_component	large ribosomal subunit
c	0022625	cellular_component	cytosolic large ribosomal subunit
c	0032991	cellular_component	protein-containing complex
c	0042273	biological_process	ribosomal large subunit biogenesis
c	1990904	cellular_component	ribonucleoprotein complex
D	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0000465	biological_process	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005515	molecular_function	protein binding
D	0005730	cellular_component	nucleolus
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	0030687	cellular_component	preribosome, large subunit precursor
D	0042134	molecular_function	rRNA primary transcript binding
D	0042254	biological_process	ribosome biogenesis
D	0042273	biological_process	ribosomal large subunit biogenesis
E	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006364	biological_process	rRNA processing
E	0019843	molecular_function	rRNA binding
E	0030687	cellular_component	preribosome, large subunit precursor
E	0042254	biological_process	ribosome biogenesis
E	0042273	biological_process	ribosomal large subunit biogenesis
E	0043023	molecular_function	ribosomal large subunit binding
E	1990904	cellular_component	ribonucleoprotein complex
F	0000027	biological_process	ribosomal large subunit assembly
F	0002181	biological_process	cytoplasmic translation
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0006364	biological_process	rRNA processing
F	0006412	biological_process	translation
F	0006414	biological_process	translational elongation
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	1990145	biological_process	maintenance of translational fidelity
F	1990904	cellular_component	ribonucleoprotein complex
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	1990904	cellular_component	ribonucleoprotein complex
H	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H	0000502	cellular_component	proteasome complex
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005730	cellular_component	nucleolus
H	0006364	biological_process	rRNA processing
H	0019843	molecular_function	rRNA binding
H	0030163	biological_process	protein catabolic process
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0030687	cellular_component	preribosome, large subunit precursor
H	0042254	biological_process	ribosome biogenesis
H	0042273	biological_process	ribosomal large subunit biogenesis
H	0042802	molecular_function	identical protein binding
H	0043023	molecular_function	ribosomal large subunit binding
H	0070180	molecular_function	large ribosomal subunit rRNA binding
H	0070628	molecular_function	proteasome binding
i	0002181	biological_process	cytoplasmic translation
i	0003735	molecular_function	structural constituent of ribosome
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	0022625	cellular_component	cytosolic large ribosomal subunit
i	1990904	cellular_component	ribonucleoprotein complex
I	0000027	biological_process	ribosomal large subunit assembly
I	0002181	biological_process	cytoplasmic translation
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0022625	cellular_component	cytosolic large ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
j	0000027	biological_process	ribosomal large subunit assembly
j	0002181	biological_process	cytoplasmic translation
j	0003735	molecular_function	structural constituent of ribosome
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005840	cellular_component	ribosome
j	0006364	biological_process	rRNA processing
j	0006412	biological_process	translation
j	0022625	cellular_component	cytosolic large ribosomal subunit
j	0042273	biological_process	ribosomal large subunit biogenesis
j	1990904	cellular_component	ribonucleoprotein complex
J	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J	0000470	biological_process	maturation of LSU-rRNA
J	0002181	biological_process	cytoplasmic translation
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	0042273	biological_process	ribosomal large subunit biogenesis
J	1990904	cellular_component	ribonucleoprotein complex
K	0000470	biological_process	maturation of LSU-rRNA
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0006364	biological_process	rRNA processing
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	0042254	biological_process	ribosome biogenesis
K	1990904	cellular_component	ribonucleoprotein complex
l	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
l	0002181	biological_process	cytoplasmic translation
l	0003729	molecular_function	mRNA binding
l	0003735	molecular_function	structural constituent of ribosome
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005840	cellular_component	ribosome
l	0006412	biological_process	translation
l	0022625	cellular_component	cytosolic large ribosomal subunit
l	0030687	cellular_component	preribosome, large subunit precursor
l	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003735	molecular_function	structural constituent of ribosome
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
m	0000470	biological_process	maturation of LSU-rRNA
m	0002181	biological_process	cytoplasmic translation
m	0003723	molecular_function	RNA binding
m	0003735	molecular_function	structural constituent of ribosome
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005840	cellular_component	ribosome
m	0006412	biological_process	translation
m	0022625	cellular_component	cytosolic large ribosomal subunit
m	0180023	biological_process	cytosolic large ribosomal subunit assembly
m	1990904	cellular_component	ribonucleoprotein complex
M	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M	0003723	molecular_function	RNA binding
M	0003729	molecular_function	mRNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0006364	biological_process	rRNA processing
M	0019843	molecular_function	rRNA binding
M	0030687	cellular_component	preribosome, large subunit precursor
M	0042254	biological_process	ribosome biogenesis
M	0042273	biological_process	ribosomal large subunit biogenesis
M	0042802	molecular_function	identical protein binding
M	0043021	molecular_function	ribonucleoprotein complex binding
M	0070180	molecular_function	large ribosomal subunit rRNA binding
M	0070545	cellular_component	PeBoW complex
n	0000448	biological_process	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0002181	biological_process	cytoplasmic translation
n	0003723	molecular_function	RNA binding
n	0003735	molecular_function	structural constituent of ribosome
n	0005515	molecular_function	protein binding
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005840	cellular_component	ribosome
n	0006412	biological_process	translation
n	0008270	molecular_function	zinc ion binding
n	0019843	molecular_function	rRNA binding
n	0022625	cellular_component	cytosolic large ribosomal subunit
n	0030687	cellular_component	preribosome, large subunit precursor
n	0046872	molecular_function	metal ion binding
n	1990904	cellular_component	ribonucleoprotein complex
N	0000054	biological_process	ribosomal subunit export from nucleus
N	0000460	biological_process	maturation of 5.8S rRNA
N	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N	0000470	biological_process	maturation of LSU-rRNA
N	0003743	molecular_function	translation initiation factor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006364	biological_process	rRNA processing
N	0006412	biological_process	translation
N	0006413	biological_process	translational initiation
N	0030687	cellular_component	preribosome, large subunit precursor
N	0042254	biological_process	ribosome biogenesis
N	0042256	biological_process	cytosolic ribosome assembly
N	0042273	biological_process	ribosomal large subunit biogenesis
N	0043022	molecular_function	ribosome binding
N	0043023	molecular_function	ribosomal large subunit binding
N	1902626	biological_process	assembly of large subunit precursor of preribosome
O	0000055	biological_process	ribosomal large subunit export from nucleus
O	0000460	biological_process	maturation of 5.8S rRNA
O	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O	0000470	biological_process	maturation of LSU-rRNA
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005730	cellular_component	nucleolus
O	0006364	biological_process	rRNA processing
O	0019843	molecular_function	rRNA binding
O	0030687	cellular_component	preribosome, large subunit precursor
O	0042134	molecular_function	rRNA primary transcript binding
O	0042254	biological_process	ribosome biogenesis
P	0002181	biological_process	cytoplasmic translation
P	0003723	molecular_function	RNA binding
P	0003735	molecular_function	structural constituent of ribosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000027	biological_process	ribosomal large subunit assembly
Q	0000470	biological_process	maturation of LSU-rRNA
Q	0002181	biological_process	cytoplasmic translation
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005730	cellular_component	nucleolus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0016236	biological_process	macroautophagy
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	0032991	cellular_component	protein-containing complex
Q	0042273	biological_process	ribosomal large subunit biogenesis
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000470	biological_process	maturation of LSU-rRNA
R	0002181	biological_process	cytoplasmic translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	0180023	biological_process	cytosolic large ribosomal subunit assembly
R	1990904	cellular_component	ribonucleoprotein complex
S	0000470	biological_process	maturation of LSU-rRNA
S	0002181	biological_process	cytoplasmic translation
S	0003723	molecular_function	RNA binding
S	0003729	molecular_function	mRNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0015934	cellular_component	large ribosomal subunit
S	0017148	biological_process	negative regulation of translation
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0000448	biological_process	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
T	0002181	biological_process	cytoplasmic translation
T	0003735	molecular_function	structural constituent of ribosome
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0015934	cellular_component	large ribosomal subunit
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	0030687	cellular_component	preribosome, large subunit precursor
T	1990904	cellular_component	ribonucleoprotein complex
U	0002181	biological_process	cytoplasmic translation
U	0003723	molecular_function	RNA binding
U	0003735	molecular_function	structural constituent of ribosome
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0022625	cellular_component	cytosolic large ribosomal subunit
U	1990904	cellular_component	ribonucleoprotein complex
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005730	cellular_component	nucleolus
V	0006364	biological_process	rRNA processing
V	0030687	cellular_component	preribosome, large subunit precursor
V	0042254	biological_process	ribosome biogenesis
V	0042273	biological_process	ribosomal large subunit biogenesis
V	1990275	molecular_function	preribosome binding
W	0002181	biological_process	cytoplasmic translation
W	0003735	molecular_function	structural constituent of ribosome
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015934	cellular_component	large ribosomal subunit
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
X	0003674	molecular_function	molecular_function
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005730	cellular_component	nucleolus
X	0006364	biological_process	rRNA processing
X	0030687	cellular_component	preribosome, large subunit precursor
X	0030688	cellular_component	preribosome, small subunit precursor
Y	0000166	molecular_function	nucleotide binding
Y	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y	0003676	molecular_function	nucleic acid binding
Y	0003723	molecular_function	RNA binding
Y	0003724	molecular_function	RNA helicase activity
Y	0004386	molecular_function	helicase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005635	cellular_component	nuclear envelope
Y	0005730	cellular_component	nucleolus
Y	0006364	biological_process	rRNA processing
Y	0008186	molecular_function	ATP-dependent activity, acting on RNA
Y	0016787	molecular_function	hydrolase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0030686	cellular_component	90S preribosome
Y	0030687	cellular_component	preribosome, large subunit precursor
Y	0042254	biological_process	ribosome biogenesis
Y	0042273	biological_process	ribosomal large subunit biogenesis
Y	0042274	biological_process	ribosomal small subunit biogenesis
Y	0042802	molecular_function	identical protein binding
Y	0070013	cellular_component	intracellular organelle lumen
Y	1990417	biological_process	snoRNA release from pre-rRNA
Z	0000460	biological_process	maturation of 5.8S rRNA
Z	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0000470	biological_process	maturation of LSU-rRNA
Z	0003674	molecular_function	molecular_function
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005730	cellular_component	nucleolus
Z	0030684	cellular_component	preribosome
Z	0030687	cellular_component	preribosome, large subunit precursor
Z	0042273	biological_process	ribosomal large subunit biogenesis

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. IIDEADRiL

Chain	Residue	Details
Y	ILE194-LEU202

---

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinkyesspSHIELvV

Chain	Residue	Details
T	ARG126-VAL150

---

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FeqnemiDaiAvTkGHGfeGvthR

Chain	Residue	Details
F	PHE209-ARG232

---

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. SLPKIKtVRKSIACV

Chain	Residue	Details
l	SER40-VAL54

---

site_id	PS00580
Number of Residues	21
Details	RIBOSOMAL_L32E Ribosomal protein L32e signature. FkRhhsdRyhRVaen..WRKqkG

Chain	Residue	Details
i	PHE17-GLY37

---

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLtRinSgTfvkvtkatleLLklIepYV

Chain	Residue	Details
J	VAL102-VAL134
D	ILE162-VAL194

---

site_id	PS00700
Number of Residues	22
Details	RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QicrVrnKdiRkFlDGIYVshK

Chain	Residue	Details
L	GLN163-LYS184

---

site_id	PS00783
Number of Residues	24
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. LRGMVShktarGKaalerLkVFeG

Chain	Residue	Details
S	LEU84-GLY107

---

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NhneKryATaSAIaATAvaslvlaRGH

Chain	Residue	Details
G	ASN114-HIS140

---

site_id	PS01077
Number of Residues	20
Details	RIBOSOMAL_L37E Ribosomal protein L37e signature. GTpSfGkRhnks.HtlCnRCG

Chain	Residue	Details
n	GLY4-GLY23

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG

Chain	Residue	Details
K	CYS170-GLY187

---

site_id	PS01104
Number of Residues	15
Details	RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFTLaEVkaaG

Chain	Residue	Details
P	ARG70-GLY84

---

site_id	PS01105
Number of Residues	22
Details	RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRtHGnsGvVrAtFrnnLP

Chain	Residue	Details
j	GLY69-PRO90

---

site_id	PS01106
Number of Residues	18
Details	RIBOSOMAL_L18E Ribosomal protein L18e signature. KaLflSKinRPpVSVsRI

Chain	Residue	Details
U	LYS50-ILE67

---

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVlVVrGskKGqe.GkI

Chain	Residue	Details
c	ASP53-ILE70

---

site_id	PS01170
Number of Residues	19
Details	RIBOSOMAL_L6E Ribosomal protein L6e signature. NgvPLRRvnarYVIATSt.K

Chain	Residue	Details
I	ASN72-LYS90

---

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRlIDLIR

Chain	Residue	Details
m	PRO52-ARG62

---

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRvRVrRG

Chain	Residue	Details
R	ASP46-GLY69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	85
Details	Region: {"description":"C-terminal-extended nuclear localization signal","evidences":[{"source":"PubMed","id":"25936803","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"1544921","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"26046779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CK1","evidences":[{"source":"HAMAP-Rule","id":"MF_03132","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	17
Details	Region: {"description":"RNA-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"10601260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	16
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"22522802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	176
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	170
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	28
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	16
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	5
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	31
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine; partial","evidences":[{"source":"PubMed","id":"10601260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	18
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22096102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---