5Z1Z

The apo-structure of D-lactate dehydrogenase from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006089	biological_process	lactate metabolic process
A	0008720	molecular_function	D-lactate dehydrogenase (NAD+) activity
A	0009408	biological_process	response to heat
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019664	biological_process	mixed acid fermentation
A	0042802	molecular_function	identical protein binding
A	0051287	molecular_function	NAD binding
A	0051289	biological_process	protein homotetramerization
A	0070404	molecular_function	NADH binding
B	0005829	cellular_component	cytosol
B	0006089	biological_process	lactate metabolic process
B	0008720	molecular_function	D-lactate dehydrogenase (NAD+) activity
B	0009408	biological_process	response to heat
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019664	biological_process	mixed acid fermentation
B	0042802	molecular_function	identical protein binding
B	0051287	molecular_function	NAD binding
B	0051289	biological_process	protein homotetramerization
B	0070404	molecular_function	NADH binding
C	0005829	cellular_component	cytosol
C	0006089	biological_process	lactate metabolic process
C	0008720	molecular_function	D-lactate dehydrogenase (NAD+) activity
C	0009408	biological_process	response to heat
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019664	biological_process	mixed acid fermentation
C	0042802	molecular_function	identical protein binding
C	0051287	molecular_function	NAD binding
C	0051289	biological_process	protein homotetramerization
C	0070404	molecular_function	NADH binding
D	0005829	cellular_component	cytosol
D	0006089	biological_process	lactate metabolic process
D	0008720	molecular_function	D-lactate dehydrogenase (NAD+) activity
D	0009408	biological_process	response to heat
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019664	biological_process	mixed acid fermentation
D	0042802	molecular_function	identical protein binding
D	0051287	molecular_function	NAD binding
D	0051289	biological_process	protein homotetramerization
D	0070404	molecular_function	NADH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 401

Chain	Residue
A	GLU21
A	HOH534
A	HOH543
A	HOH546
C	HOH401
C	HOH406

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PEG A 402

Chain	Residue
A	PHE29
A	THR8
A	GLN10
A	LYS13

---

Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. AGVIGtGKIGvamlrilkgfgmr.LLaFD

Chain	Residue	Details
A	ALA147-ASP174

---

site_id	PS00670
Number of Residues	23
Details	D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. LFseSDVIsLHcPltpeNyhLlN

Chain	Residue	Details
A	LEU194-ASN216

---

site_id	PS00671
Number of Residues	17
Details	D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKnGvMIVNtSRGaLID

Chain	Residue	Details
A	MET223-ASP239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P26297","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P26297","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30901","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26297","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---